STRINGSTRING
SCARB1 SCARB1 SCARF2 SCARF2 LOXL4 LOXL4 TMPRSS2 TMPRSS2 CXCL16 CXCL16 SSC5D SSC5D TMPRSS4 TMPRSS4 ENSSSCP00000051045 ENSSSCP00000051045 ENSSSCP00000050431 ENSSSCP00000050431 SCART1 SCART1 HHIPL2 HHIPL2 ACKR4 ACKR4 CD5 CD5 CD36 CD36 ACKR3 ACKR3 PRG4 PRG4 VTN VTN TMPRSS3 TMPRSS3 SCARF1 SCARF1 MARCO MARCO CD6 CD6 K7GRI9_PIG K7GRI9_PIG K7GT09_PIG K7GT09_PIG ENPP2 ENPP2 ENDOU ENDOU A0A286ZUU1_PIG A0A286ZUU1_PIG CD163L1 CD163L1 A0A287A4N3_PIG A0A287A4N3_PIG ENPP1 ENPP1 MEGF11 MEGF11 A0A287AJS7_PIG A0A287AJS7_PIG STAB1 STAB1 CD163 CD163 LOXL2 LOXL2 CFI CFI SSC4D SSC4D STAB2 STAB2 CD5L CD5L MSR1 MSR1 PRSS12 PRSS12 SCARA5 SCARA5 LGALS3BP LGALS3BP A0A5G2QZ01_PIG A0A5G2QZ01_PIG TMPRSS15 TMPRSS15 A0A5G2R217_PIG A0A5G2R217_PIG LOXL3 LOXL3 ACKR2 ACKR2 SCARB2 SCARB2 LOC110258535 LOC110258535 LOC100627089 LOC100627089 LOC110259119 LOC110259119 TMPRSS13 TMPRSS13 ENSSSCP00000055398 ENSSSCP00000055398 COLEC12 COLEC12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCARB1Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa)
SCARF2Scavenger receptor class F member 2. (873 aa)
LOXL4Lysyl oxidase like 4. (757 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (526 aa)
CXCL16C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). (342 aa)
SSC5DScavenger receptor cysteine rich family member with 5 domains. (1634 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (435 aa)
ENSSSCP00000051045annotation not available (71 aa)
ENSSSCP00000050431annotation not available (71 aa)
SCART1Scavenger receptor family member expressed on T cells 1. (1052 aa)
HHIPL2HHIP like 2. (830 aa)
ACKR4Chemokine (C-C motif) receptor-like protein 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
CD5T-cell surface glycoprotein CD5 isoform 1. (497 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PRG4Uncharacterized protein. (370 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (557 aa)
SCARF1Scavenger receptor class F member 1 isoform 1. (869 aa)
MARCOSRCR domain-containing protein. (447 aa)
CD6CD6 molecule. (671 aa)
K7GRI9_PIGUncharacterized protein; Belongs to the CD36 family. (71 aa)
K7GT09_PIGSRCR domain-containing protein. (155 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X3. (1006 aa)
ENDOUEndonuclease, poly(U) specific. (410 aa)
A0A286ZUU1_PIGUncharacterized protein. (889 aa)
CD163L1Uncharacterized protein. (959 aa)
A0A287A4N3_PIGUncharacterized protein. (682 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
A0A287AJS7_PIGUncharacterized protein. (730 aa)
STAB1Stabilin 1. (2684 aa)
CD163Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] (1113 aa)
LOXL2Lysyl oxidase like 2. (758 aa)
CFIComplement factor I isoform 1 preproprotein; Belongs to the peptidase S1 family. (587 aa)
SSC4DScavenger receptor cysteine rich family member with 4 domains. (621 aa)
STAB2Uncharacterized protein. (2550 aa)
CD5LUncharacterized protein. (574 aa)
MSR1Macrophage scavenger receptor 1. (446 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
SCARA5SRCR domain-containing protein. (269 aa)
LGALS3BPGalectin 3 binding protein. (551 aa)
A0A5G2QZ01_PIGUncharacterized protein. (353 aa)
TMPRSS15Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. (1049 aa)
A0A5G2R217_PIGUncharacterized protein. (1028 aa)
LOXL3Lysyl oxidase like 3. (814 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (385 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (480 aa)
LOC110258535Uncharacterized protein. (958 aa)
LOC100627089Uncharacterized protein. (812 aa)
LOC110259119Uncharacterized protein. (674 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (526 aa)
ENSSSCP00000055398annotation not available (71 aa)
COLEC12Collectin subfamily member 12. (751 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.