STRINGSTRING
SMAD3 SMAD3 MUSK MUSK SPARC SPARC CCBE1 CCBE1 COL6A6 COL6A6 ITGA1 ITGA1 ANTXR1 ANTXR1 COL6A1 COL6A1 ACHE ACHE ABI3BP ABI3BP LOC100517188 LOC100517188 FNDC1 FNDC1 C1QTNF8 C1QTNF8 CHADL CHADL ITGA11 ITGA11 USH2A USH2A FSTL3 FSTL3 DSPP DSPP C1QTNF1 C1QTNF1 PDGFB PDGFB ITGA10 ITGA10 C6orf15 C6orf15 ADGRG1 ADGRG1 SERPINH1 SERPINH1 DDR1 DDR1 ITGB1 ITGB1 TNXB TNXB PAK1 PAK1 VWF VWF DCN DCN ECM2 ECM2 GP6 GP6 COL6A2 COL6A2 SRGN SRGN HSD17B12 HSD17B12 CPN2 CPN2 PODN PODN COCH COCH LUM LUM SMAD7 SMAD7 SMAD4 SMAD4 THBS1 THBS1 DDR2 DDR2 CTSS CTSS PDGFA PDGFA ASPN ASPN SPARCL1 SPARCL1 NID1 NID1 PODNL1 PODNL1 COMP COMP LRRC15 LRRC15 MRC2 MRC2 ITGA2 ITGA2 AEBP1 AEBP1 LOX LOX TGFBI TGFBI RELL2 RELL2 GP5 GP5 MMP13 MMP13 ADAM9 ADAM9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (434 aa)
MUSKMuscle associated receptor tyrosine kinase. (869 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa)
CCBE1Collagen and calcium binding EGF domains 1. (407 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa)
ANTXR1ANTXR cell adhesion molecule 1. (564 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
ACHEAcetylcholinesterase (Cartwright blood group); Belongs to the type-B carboxylesterase/lipase family. (765 aa)
ABI3BPABI family member 3 binding protein. (1668 aa)
LOC100517188Uncharacterized protein. (1592 aa)
FNDC1Fibronectin type III domain containing 1. (1764 aa)
C1QTNF8C1q and TNF related 8. (251 aa)
CHADLChondroadherin like. (760 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1282 aa)
USH2AUncharacterized protein. (1544 aa)
FSTL3Follistatin-related protein 3. (262 aa)
DSPPUncharacterized protein. (1023 aa)
C1QTNF1C1q and TNF related 1. (273 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa)
C6orf15Chromosome 6 open reading frame 15. (306 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (740 aa)
SERPINH1SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
DDR1Tyrosine-protein kinase receptor. (1005 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
TNXBUncharacterized protein. (4137 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
ECM2Extracellular matrix protein 2. (696 aa)
GP6Ig-like domain-containing protein. (319 aa)
COL6A2Collagen type VI alpha 2 chain. (943 aa)
SRGNSerglycin. (152 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
CPN2Carboxypeptidase N subunit 2. (560 aa)
PODNLRRNT domain-containing protein. (697 aa)
COCHCochlin isoform X2. (551 aa)
LUMLumican. (341 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
THBS1Uncharacterized protein. (1170 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (866 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (341 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa)
ASPNAsporin. (370 aa)
SPARCL1SPARC like 1. (675 aa)
NID1Nidogen 1. (1309 aa)
PODNL1Podocan like 1. (576 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
LRRC15Leucine rich repeat containing 15. (581 aa)
MRC2Mannose receptor C type 2. (1264 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
AEBP1Adipocyte enhancer-binding protein 1. (1140 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
TGFBITransforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions. (709 aa)
RELL2RELT like 2. (305 aa)
GP5Glycoprotein V platelet. (569 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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