Your Input: | |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (305 aa) |
| | MARCHF5 | Membrane associated ring-CH-type finger 5. (145 aa) |
| | LRRK2 | Uncharacterized protein. (2501 aa) |
| | LOC100525346 | Uncharacterized protein. (459 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A. (654 aa) |
| | PINK1 | PTEN induced kinase 1. (588 aa) |
| | FOXO3 | Forkhead box protein O3 isoform X1. (672 aa) |
| | BCL2L10 | Uncharacterized protein. (184 aa) |
| | TOMM20L | Translocase of outer mitochondrial membrane 20 like. (152 aa) |
| | TOMM5 | Mitochondrial import receptor subunit TOM5. (51 aa) |
| | MIGA2 | Mitoguardin 2. (592 aa) |
| | ARMC1 | Armadillo repeat-containing protein 1. (282 aa) |
| | TOMM40L | Translocase of outer mitochondrial membrane 40 like. (308 aa) |
| | MTX1 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family. (463 aa) |
| | HAX1 | HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family. (284 aa) |
| | PI4KB | Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (841 aa) |
| | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1. (402 aa) |
| | VDAC3 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (284 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (532 aa) |
| | FAM210B | Family with sequence similarity 210 member B. (239 aa) |
| | HK2 | Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa) |
| | HADHB | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (511 aa) |
| | MGARP | AIF-MLS domain-containing protein. (238 aa) |
| | CISD2 | CDGSH iron-sulfur domain-containing protein 2. (135 aa) |
| | LOC100520401 | ZnF_CDGSH domain-containing protein. (106 aa) |
| | VDAC2 | Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (294 aa) |
| | ATAD1 | ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (361 aa) |
| | SFXN2 | Sidoreflexin. (322 aa) |
| | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (825 aa) |
| | MARC2 | Mitochondrial amidoxime reducing component 2; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] (339 aa) |
| | GK | Uncharacterized protein; Belongs to the FGGY kinase family. (590 aa) |
| | MAOA | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (946 aa) |
| | CPT1A | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa) |
| | QTRT1 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (403 aa) |
| | SLC25A46 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (205 aa) |
| | STING1 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa) |
| | C11orf65 | Chromosome 11 open reading frame 65. (313 aa) |
| | TOMM7 | Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). (55 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6 (Langereis blood group). (843 aa) |
| | UBB | Ubiquitin B. (229 aa) |
| | ZNFX1 | Zinc finger NFX1-type containing 1. (1926 aa) |
| | SYNJ2BP | Synaptojanin 2 binding protein. (164 aa) |
| | VAT1 | Synaptic vesicle membrane protein VAT-1 homolog. (400 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | SPATA19 | Spermatogenesis-associated protein 19, mitochondrial. (154 aa) |
| | BNIP3 | BCL2 interacting protein 3. (202 aa) |
| | PODN | LRRNT domain-containing protein. (697 aa) |
| | MAOB | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (518 aa) |
| | PDE2A | Phosphodiesterase. (1010 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | MTX3 | Metaxin. (320 aa) |
| | MTX2 | Metaxin-2; Involved in transport of proteins into the mitochondrion. (284 aa) |
| | PGRMC1 | Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). (194 aa) |
| | FUNDC1 | FUN14 domain containing 1. (158 aa) |
| | HK3 | Hexokinase 3. (890 aa) |
| | BNIP5 | BCL2 interacting protein 5. (651 aa) |
| | BAK1 | Uncharacterized protein. (266 aa) |
| | BCL2L1 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa) |
| | LOC100739656 | Uncharacterized protein. (128 aa) |
| | HKDC1 | Hexokinase domain containing 1. (917 aa) |
| | BCL2A1 | Bcl-2-related protein A1 isoform 1. (175 aa) |
| | MTCH2 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (334 aa) |
| | PLD6 | Phospholipase D family member 6. (221 aa) |
| | SOX10 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa) |
| | GDAP1 | Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (362 aa) |
| | QTRT2 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (482 aa) |
| | DAO | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. (371 aa) |
| | RHOT1 | Ras homolog family member T1. (752 aa) |
| | MGST1 | Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the MAPEG family. (155 aa) |
| | MFN1 | Mitochondrial mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa) |
| | DMPK | DM1 protein kinase. (590 aa) |
| | SPATA18 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] (577 aa) |
| | TRIM14 | Tripartite motif-containing protein 14 isoform X1. (445 aa) |
| | TOMM22 | Uncharacterized protein. (207 aa) |
| | HK1 | Uncharacterized protein. (919 aa) |
| | TOMM20 | Translocase of outer mitochondrial membrane 20. (152 aa) |
| | ENSA | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity); Belongs to the endosulfine [...] (137 aa) |
| | CNR1 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa) |
| | LPIN1 | Lipin 1. (957 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (547 aa) |
| | VPS13A | Vacuolar protein sorting 13 homolog A. (3171 aa) |
| | A0A5G2QRP7_PIG | Uncharacterized protein. (104 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | RAB11FIP5 | Uncharacterized protein. (1391 aa) |
| | RTN4IP1 | Reticulon 4 interacting protein 1. (476 aa) |
| | CYB5B | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (148 aa) |
| | CISD1 | ZnF_CDGSH domain-containing protein. (135 aa) |
| | OPA1 | OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1020 aa) |
| | TOMM40 | Translocase of outer mitochondrial membrane 40. (400 aa) |
| | TOMM70 | Translocase of outer mitochondrial membrane 70. (609 aa) |
| | FUNDC2 | FUN14 domain-containing protein 2; Belongs to the FUN14 family. (215 aa) |
| | AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa) |
| | UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) |
| | VPS13C | Vacuolar protein sorting 13 homolog C. (3757 aa) |
| | MFF | Miff domain-containing protein. (341 aa) |
| | A0A5G2QGL4_PIG | Uncharacterized protein. (51 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa) |
| | CYB5R3 | NADH-cytochrome b5 reductase 3; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. (300 aa) |
| | A0A287BQP7_PIG | Mab-21 domain-containing protein. (155 aa) |
| | SPART | Spartin. (666 aa) |
| | TOMM34 | Translocase of outer mitochondrial membrane 34. (309 aa) |
| | MFN2 | Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1. (351 aa) |
| | RAB38 | Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Belongs to the small GTPase superfam [...] (211 aa) |
| | TOMM6 | Translocase of outer mitochondrial membrane 6. (74 aa) |
| | A0A287BBW3_PIG | ZnF_CDGSH domain-containing protein. (123 aa) |
| | TAZ | Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (395 aa) |
| | A0A287BD08_PIG | Uncharacterized protein; Belongs to the FGGY kinase family. (526 aa) |
| | AIFM2 | Apoptosis inducing factor mitochondria associated 2. (415 aa) |
| | USP30 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (516 aa) |
| | RMDN3 | Regulator of microtubule dynamics 3. (470 aa) |
| | PLEC | Plectin. (5422 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | RSAD2 | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa) |
| | MIEF2 | Mitochondrial elongation factor 2. (472 aa) |
| | MYO19 | Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1005 aa) |
| | BID | BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa) |
| | GCK | Glucokinase. (659 aa) |
| | FATE1 | Fetal and adult testis-expressed transcript protein homolog; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. (171 aa) |
| | VDAC1 | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (302 aa) |
| | A0A287AS79_PIG | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (232 aa) |
| | WASF1 | WH2 domain-containing protein. (559 aa) |
| | MIEF1 | Mitochondrial dynamics protein MID51 isoform X1. (463 aa) |
| | ARMCX3 | Armadillo repeat-containing X-linked protein 3. (379 aa) |
| | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform. (807 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (288 aa) |
| | BNIP3L | BCL2 interacting protein 3 like. (204 aa) |
| | LOC110256054 | WH2 domain-containing protein. (558 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | CPT1C | Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (732 aa) |
| | FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) |
| | MYOC | Myocilin. (489 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (802 aa) |
| | MSTO1 | Misato mitochondrial distribution and morphology regulator 1. (566 aa) |
| | SAMM50 | SAMM50 sorting and assembly machinery component. (469 aa) |
| | LETMD1 | LETM1 domain-containing protein 1 isoform a. (360 aa) |
