STRINGSTRING
FOXL1 FOXL1 HS3ST5 HS3ST5 EXT1 EXT1 SULF1 SULF1 B4GALNT4 B4GALNT4 LOC100517735 LOC100517735 SULF2 SULF2 CHST12 CHST12 XYLT1 XYLT1 CHST10 CHST10 CYTL1 CYTL1 NDNF NDNF NDST3 NDST3 HPSE HPSE HS6ST3 HS6ST3 CSGALNACT2 CSGALNACT2 CHST13 CHST13 EXT2 EXT2 IHH IHH CHPF2 CHPF2 HYAL4 HYAL4 EGFLAM EGFLAM SGSH SGSH XYLT2 XYLT2 GLCE GLCE HS6ST1 HS6ST1 HS6ST2 HS6ST2 CHPF CHPF BMPR1B BMPR1B UGDH UGDH B3GAT3 B3GAT3 ADAMTS12 ADAMTS12 B3GAT2 B3GAT2 B3GALT6 B3GALT6 MAMDC2 MAMDC2 BGN BGN CHST7 CHST7 CHST8 CHST8 DSE DSE NDST1 NDST1 IDUA IDUA B3GAT1 B3GAT1 PSAP PSAP COL2A1 COL2A1 BMP2 BMP2 CHST3 CHST3 IMPAD1 IMPAD1 HS2ST1 HS2ST1 CANT1 CANT1 FAM20B FAM20B DSEL DSEL GPC1 GPC1 SPOCK2 SPOCK2 CSGALNACT1 CSGALNACT1 CHSY1 CHSY1 B4GALNT3 B4GALNT3 NDST4 NDST4 CHST9 CHST9 ACAN ACAN CHST11 CHST11 EXTL3 EXTL3 NDST2 NDST2 PXYLP1 PXYLP1 CHSY3 CHSY3 B4GALT7 B4GALT7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXL1Forkhead box protein L1. (338 aa)
HS3ST5Sulfotransferase; Belongs to the sulfotransferase 1 family. (345 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SULF1Sulfatase 1. (1108 aa)
B4GALNT4Hexosyltransferase. (1072 aa)
LOC100517735Hexosyltransferase. (384 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa)
CHST12Carbohydrate sulfotransferase. (519 aa)
XYLT1Xylosyltransferase 1. (956 aa)
CHST10Carbohydrate sulfotransferase. (476 aa)
CYTL1Cytokine like 1. (149 aa)
NDNFNeuron derived neurotrophic factor. (664 aa)
NDST3Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X2. (887 aa)
HPSEHeparanase isoform 1 preproprotein. (551 aa)
HS6ST3Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (472 aa)
CSGALNACT2Hexosyltransferase. (542 aa)
CHST13Carbohydrate sulfotransferase. (343 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (688 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
CHPF2Hexosyltransferase. (772 aa)
HYAL4Hyaluronidase. (482 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (745 aa)
SGSHN-sulfoglucosamine sulfohydrolase. (505 aa)
XYLT2Xylosyltransferase 2. (864 aa)
GLCEGlucuronic acid epimerase. (617 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
HS6ST2Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (644 aa)
CHPFHexosyltransferase. (775 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (339 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
B3GAT2Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (323 aa)
B3GALT6Hexosyltransferase. (323 aa)
MAMDC2MAM domain containing 2. (685 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
CHST7Sulfotransferase; Belongs to the sulfotransferase 1 family. (456 aa)
CHST8Carbohydrate sulfotransferase. (424 aa)
DSEDermatan-sulfate epimerase isoform X1. (957 aa)
NDST1Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2. (882 aa)
IDUAIduronidase alpha-L-. (643 aa)
B3GAT1Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (347 aa)
PSAPSaposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. (573 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
CHST3Sulfotransferase; Belongs to the sulfotransferase 1 family. (486 aa)
IMPAD1Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa)
HS2ST1Uncharacterized protein. (356 aa)
CANT1Calcium activated nucleotidase 1. (371 aa)
FAM20BFAM20B glycosaminoglycan xylosylkinase. (409 aa)
DSELDermatan-sulfate epimerase-like protein. (1212 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
CSGALNACT1Hexosyltransferase. (525 aa)
CHSY1Hexosyltransferase. (803 aa)
B4GALNT3Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (998 aa)
NDST4N-deacetylase and N-sulfotransferase 4. (871 aa)
CHST9Carbohydrate sulfotransferase. (477 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
EXTL3Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (919 aa)
NDST2Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1. (883 aa)
PXYLP12-phosphoxylose phosphatase 1; Belongs to the histidine acid phosphatase family. (505 aa)
CHSY3Hexosyltransferase. (882 aa)
B4GALT7Uncharacterized protein. (404 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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