25 items (Sus scrofa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Predicted Interactions

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protein homology

Your Input:
	HMGCS2	Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (508 aa)
	ACSS2	Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa)
	AASS	Aminoadipate-semialdehyde synthase. (961 aa)
	ACOT12	Acyl-coenzyme A thioesterase 12 isoform X1. (559 aa)
	PIPOX	Pipecolic acid and sarcosine oxidase. (401 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	ACSS1	Acetyl-coenzyme A synthetase. (703 aa)
	MVD	Mevalonate diphosphate decarboxylase. (474 aa)
	MPC2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
	NUDT8	Nudix hydrolase domain-containing protein. (140 aa)
	MLYCD	Malonyl-CoA decarboxylase. (499 aa)
	DLST	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex. The 2- oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl [...] (446 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
	NUDT7	Nudix hydrolase 7. (237 aa)
	PDHX	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (498 aa)
	ACACB	Biotin carboxylation domain-containing protein. (229 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (667 aa)
	TDO2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (486 aa)
	PPCS	Phosphopantothenoylcysteine synthetase. (311 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	MVK	Mevalonate kinase. (454 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (576 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1130 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. (396 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASS	PIPOX	ENSSSCP00000053239	ENSSSCP00000047730	Aminoadipate-semialdehyde synthase.	Pipecolic acid and sarcosine oxidase.	0.521
ACACA	ACACB	ENSSSCP00000047454	ENSSSCP00000067823	Acetyl-CoA carboxylase alpha.	Biotin carboxylation domain-containing protein.	0.932
ACACA	ACAT1	ENSSSCP00000047454	ENSSSCP00000025827	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.961
ACACA	ACLY	ENSSSCP00000047454	ENSSSCP00000018460	Acetyl-CoA carboxylase alpha.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.979
ACACA	ACOT12	ENSSSCP00000047454	ENSSSCP00000049040	Acetyl-CoA carboxylase alpha.	Acyl-coenzyme A thioesterase 12 isoform X1.	0.915
ACACA	ACSS1	ENSSSCP00000047454	ENSSSCP00000047124	Acetyl-CoA carboxylase alpha.	Acetyl-coenzyme A synthetase.	0.950
ACACA	ACSS2	ENSSSCP00000047454	ENSSSCP00000055106	Acetyl-CoA carboxylase alpha.	Acetyl-coenzyme A synthetase, cytoplasmic isoform X1.	0.974
ACACA	DLAT	ENSSSCP00000047454	ENSSSCP00000070907	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.935
ACACA	HMGCS1	ENSSSCP00000047454	ENSSSCP00000017880	Acetyl-CoA carboxylase alpha.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.487
ACACA	MLYCD	ENSSSCP00000047454	ENSSSCP00000058067	Acetyl-CoA carboxylase alpha.	Malonyl-CoA decarboxylase.	0.929
ACACA	MVD	ENSSSCP00000047454	ENSSSCP00000037983	Acetyl-CoA carboxylase alpha.	Mevalonate diphosphate decarboxylase.	0.401
ACACB	ACACA	ENSSSCP00000067823	ENSSSCP00000047454	Biotin carboxylation domain-containing protein.	Acetyl-CoA carboxylase alpha.	0.932
ACACB	ACAT1	ENSSSCP00000067823	ENSSSCP00000025827	Biotin carboxylation domain-containing protein.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.941
ACACB	ACLY	ENSSSCP00000067823	ENSSSCP00000018460	Biotin carboxylation domain-containing protein.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.934
ACACB	ACOT12	ENSSSCP00000067823	ENSSSCP00000049040	Biotin carboxylation domain-containing protein.	Acyl-coenzyme A thioesterase 12 isoform X1.	0.904
ACACB	ACSS1	ENSSSCP00000067823	ENSSSCP00000047124	Biotin carboxylation domain-containing protein.	Acetyl-coenzyme A synthetase.	0.928
ACACB	ACSS2	ENSSSCP00000067823	ENSSSCP00000055106	Biotin carboxylation domain-containing protein.	Acetyl-coenzyme A synthetase, cytoplasmic isoform X1.	0.933
ACACB	DLAT	ENSSSCP00000067823	ENSSSCP00000070907	Biotin carboxylation domain-containing protein.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.921
ACACB	MLYCD	ENSSSCP00000067823	ENSSSCP00000058067	Biotin carboxylation domain-containing protein.	Malonyl-CoA decarboxylase.	0.937
ACAT1	ACACA	ENSSSCP00000025827	ENSSSCP00000047454	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase alpha.	0.961