STRINGSTRING
LRRC27 LRRC27 DIS3 DIS3 KHSRP KHSRP CNOT6 CNOT6 LSM4 LSM4 NCBP1 NCBP1 CNOT8 CNOT8 YTHDF2 YTHDF2 SWT1 SWT1 SND1 SND1 XRN1 XRN1 ZFP36L2 ZFP36L2 TTC37 TTC37 PYM1 PYM1 UPF3A UPF3A LSM2 LSM2 SMG1 SMG1 SMG9 SMG9 CNOT2 CNOT2 LOC110258923 LOC110258923 LSM1 LSM1 PATL1 PATL1 DNA2 DNA2 METTL14 METTL14 NUDT16 NUDT16 PNPT1 PNPT1 RNASET2 RNASET2 SMG5 SMG5 TTC38 TTC38 CNOT3 CNOT3 RC3H1 RC3H1 RNASEH2A RNASEH2A PAN2 PAN2 CNOT7 CNOT7 DHX34 DHX34 UPF1 UPF1 TENT2 TENT2 EXOSC9 EXOSC9 AGO1 AGO1 XRN2 XRN2 DXO DXO RIDA RIDA MRTO4 MRTO4 ERN2 ERN2 SAMD4B SAMD4B UPF2 UPF2 RNASEH1 RNASEH1 PABPC1 PABPC1 NOCT NOCT SMG8 SMG8 SMG7 SMG7 CNOT1 CNOT1 THRAP3 THRAP3 RBM8A RBM8A DCP1A DCP1A DCP1B DCP1B ZFP36 ZFP36 RNASEH2B RNASEH2B PABPN1L PABPN1L ISG20 ISG20 FEN1 FEN1 SMG6 SMG6 CASC3 CASC3 EIF4A3 EIF4A3 MTREX MTREX PELO PELO DCPS DCPS SIDT2 SIDT2 ZPR1 ZPR1 ATM ATM ETF1 ETF1 DCP2 DCP2 NUDT12 NUDT12 RNASEH2C RNASEH2C UPF3B UPF3B PDE12 PDE12 WDR82 WDR82 EXOSC7 EXOSC7 MTPAP MTPAP SUPV3L1 SUPV3L1 PAN3 PAN3 CNOT6L CNOT6L NBAS NBAS LRPPRC LRPPRC CNOT11 CNOT11 POP1 POP1 EIF3E EIF3E EXOSC4 EXOSC4 EXOSC1 EXOSC1 POLR2G POLR2G SAMD4A SAMD4A EXOSC2 EXOSC2 ZHX2 ZHX2 LSM7 LSM7 ZC3H4 ZC3H4 PARN PARN CNOT10 CNOT10 CNOT9 CNOT9 LIN28B LIN28B EXOSC3 EXOSC3 ZCCHC7 ZCCHC7 DIS3L DIS3L ZC3H12D ZC3H12D MAGOH MAGOH EXOSC10 EXOSC10 HELZ2 HELZ2 NANOS2 NANOS2 EXOSC5 EXOSC5 EDC4 EDC4 EXOSC6 EXOSC6 EDC3 EDC3 SKIV2L SKIV2L ZC3H12A ZC3H12A AGO4 AGO4 CTIF CTIF DIS3L2 DIS3L2 DDX5 DDX5 SLFN14 SLFN14 RC3H2 RC3H2 SSB SSB CSDE1 CSDE1 ZFP36L1 ZFP36L1 EXOSC8 EXOSC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRC27Leucine rich repeat containing 27. (557 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
KHSRPKH-type splicing regulatory protein. (784 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (590 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (234 aa)
NCBP1Nuclear cap binding protein subunit 1. (1117 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (312 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
SWT1SWT1 RNA endoribonuclease homolog. (900 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
XRN15'-3' exoribonuclease 1. (1703 aa)
ZFP36L2ZFP36 ring finger protein like 2. (564 aa)
TTC37Tetratricopeptide repeat protein 37 isoform X1. (1563 aa)
PYM1PYM homolog 1, exon junction complex associated factor. (266 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (502 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3646 aa)
SMG9SMG9 nonsense mediated mRNA decay factor. (542 aa)
CNOT2NOT2_3_5 domain-containing protein. (578 aa)
LOC110258923Uncharacterized protein. (982 aa)
LSM1Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (302 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (786 aa)
DNA2DNA replication helicase/nuclease 2. (1084 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
NUDT16Nudix hydrolase 16. (211 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (784 aa)
RNASET2Ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). (363 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1016 aa)
TTC38Tetratricopeptide repeat domain 38. (490 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (774 aa)
RC3H1Ring finger and CCCH-type domains 1. (1132 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (333 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
CNOT7CCR4-NOT transcription complex subunit 7 isoform 1. (285 aa)
DHX34DExH-box helicase 34. (1098 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
TENT2Poly(A) RNA polymerase GLD2 isoform X3. (484 aa)
EXOSC9Exosome component 9. (455 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (1168 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (930 aa)
DXODecapping exoribonuclease. (395 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (272 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (989 aa)
SAMD4BSterile alpha motif domain containing 4B. (827 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1270 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (287 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
NOCTNocturnin. (427 aa)
SMG8Uncharacterized protein. (993 aa)
SMG7SMG7 nonsense mediated mRNA decay factor. (1170 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2343 aa)
THRAP3Thyroid hormone receptor-associated protein 3 isoform 1. (958 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
DCP1AmRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family. (580 aa)
DCP1BDecapping mRNA 1B. (559 aa)
ZFP36Uncharacterized protein. (372 aa)
RNASEH2BRibonuclease H2 subunit B. (316 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (282 aa)
ISG20Interferon stimulated exonuclease gene 20. (189 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1412 aa)
CASC3CASC3 exon junction complex subunit. (633 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (488 aa)
MTREXExosome RNA helicase MTR4. (1042 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (384 aa)
DCPSm7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not h [...] (337 aa)
SIDT2SID1 transmembrane family member 2. (860 aa)
ZPR1ZPR1 zinc finger. (455 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa)
ETF1Eukaryotic peptide chain release factor subunit 1 isoform 1. (437 aa)
DCP2Decapping mRNA 2. (478 aa)
NUDT12Nudix hydrolase 12. (472 aa)
RNASEH2CRibonuclease H2 subunit C. (167 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (483 aa)
PDE122',5'-phosphodiesterase 12 isoform 1. (609 aa)
WDR82WD repeat domain 82. (313 aa)
EXOSC7Uncharacterized protein. (349 aa)
MTPAPPoly(A) RNA polymerase, mitochondrial. (598 aa)
SUPV3L1Suv3 like RNA helicase. (788 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (906 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (651 aa)
NBASNeuroblastoma amplified sequence. (2318 aa)
LRPPRCLeucine-rich PPR motif-containing protein, mitochondrial. (1394 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (512 aa)
POP1POP1 homolog, ribonuclease P/MRP subunit. (1003 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
EXOSC4Exosome complex component RRP41. (245 aa)
EXOSC1Exosome component 1. (255 aa)
POLR2GRNA polymerase II subunit G. (231 aa)
SAMD4ASterile alpha motif domain containing 4A. (718 aa)
EXOSC2Exosome component 2. (271 aa)
ZHX2Zinc fingers and homeoboxes 2. (827 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (150 aa)
ZC3H4Zinc finger CCCH-type containing 4. (1249 aa)
PARNPoly(A)-specific ribonuclease. (715 aa)
CNOT10CCR4-NOT transcription complex subunit 10. (803 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (300 aa)
LIN28BLin-28 homolog B. (258 aa)
EXOSC3Exosome complex component RRP40 isoform 1. (275 aa)
ZCCHC7Zinc finger CCHC-type containing 7. (545 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1054 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (507 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
EXOSC10Exosome component 10. (869 aa)
HELZ2Helicase with zinc finger 2. (2902 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
EXOSC5Exosome component 5. (299 aa)
EDC4Enhancer of mRNA decapping 4. (1402 aa)
EXOSC6Exosome component 6. (272 aa)
EDC3Enhancer of mRNA decapping 3. (508 aa)
SKIV2LSki2 like RNA helicase. (1246 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (878 aa)
CTIFCap binding complex dependent translation initiation factor. (608 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (914 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
SLFN14Schlafen family member 14. (912 aa)
RC3H2Ring finger and CCCH-type domains 2. (1192 aa)
SSBSmall RNA binding exonuclease protection factor La. (401 aa)
CSDE1Cold shock domain containing E1. (851 aa)
ZFP36L1ZFP36 ring finger protein like 1. (348 aa)
EXOSC8Exosome component 8. (281 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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