STRINGSTRING
GPAM GPAM LIPH LIPH PNPLA4 PNPLA4 LPIN3 LPIN3 GK GK DGKK DGKK PNPLA2 PNPLA2 DAGLA DAGLA FGGY FGGY CAT CAT AGPAT5 AGPAT5 DDHD2 DDHD2 DGKD DGKD DGKE DGKE ABHD12B ABHD12B LOC100624333 LOC100624333 ABHD12 ABHD12 PCSK9 PCSK9 LYPLA2 LYPLA2 DGKG DGKG GPAT2 GPAT2 PNPLA3 PNPLA3 LIPG LIPG APOH APOH PCK1 PCK1 AWAT2 AWAT2 TNXB TNXB LIPI LIPI CAV1 CAV1 CAV3 CAV3 LPIN2 LPIN2 LMF1 LMF1 ABHD16B ABHD16B MGLL MGLL INSIG1 INSIG1 DGKZ DGKZ ABHD6 ABHD6 ABHD2 ABHD2 GK5 GK5 INSIG2 INSIG2 SLC22A4 SLC22A4 MOGAT2 MOGAT2 DGKI DGKI PCK2 PCK2 APOB APOB APOBR APOBR DGKA DGKA LOC110259135 LOC110259135 G6PC G6PC PLCE1 PLCE1 FAAH FAAH PNLIPRP2 PNLIPRP2 CPS1 CPS1 DGAT2 DGAT2 DGKB DGKB A0A287BD08_PIG A0A287BD08_PIG SLC27A5 SLC27A5 LIPE LIPE DGAT2L6 DGAT2L6 GPAT3 GPAT3 PNPLA4-2 PNPLA4-2 LPL LPL PLA2G4A PLA2G4A SLC37A4 SLC37A4 DGKQ DGKQ APOC3 APOC3 ABHD16A ABHD16A PTPN11 PTPN11 ANG ANG LPIN1 LPIN1 APOA2 APOA2 DGAT1 DGAT1 APOE APOE PNPLA1 PNPLA1 APOBEC1 APOBEC1 GPAT4 GPAT4 LIPC LIPC F1SU50_PIG F1SU50_PIG MTTP MTTP SIRT1 SIRT1 NKX2-3 NKX2-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (825 aa)
LIPHLipase H. (451 aa)
PNPLA4PNPLA domain-containing protein. (320 aa)
LPIN3LNS2 domain-containing protein. (826 aa)
GKUncharacterized protein; Belongs to the FGGY kinase family. (590 aa)
DGKKDiacylglycerol kinase. (1266 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2 isoform X1. (486 aa)
DAGLADiacylglycerol lipase alpha. (1058 aa)
FGGYFGGY carbohydrate kinase domain containing. (559 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (550 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (362 aa)
DDHD2Phospholipase DDHD2 isoform 1. (715 aa)
DGKDDiacylglycerol kinase. (1244 aa)
DGKEDiacylglycerol kinase. (566 aa)
ABHD12BAbhydrolase domain containing 12B. (441 aa)
LOC100624333Uncharacterized protein. (361 aa)
ABHD12Monoacylglycerol lipase ABHD12 isoform a. (396 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (678 aa)
LYPLA2Acyl-protein thioesterase 2 isoform X3. (281 aa)
DGKGDiacylglycerol kinase. (791 aa)
GPAT2PlsC domain-containing protein. (800 aa)
PNPLA3Patatin like phospholipase domain containing 3. (441 aa)
LIPGLipase G, endothelial type. (501 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (841 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (329 aa)
TNXBUncharacterized protein. (4137 aa)
LIPILipase I. (480 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
CAV3Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa)
LPIN2Lipin 2. (937 aa)
LMF1Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (565 aa)
ABHD16BAbhydrolase domain containing 16B. (470 aa)
MGLLMonoglyceride lipase. (456 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (308 aa)
DGKZDiacylglycerol kinase. (1144 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
ABHD2Abhydrolase domain containing 2. (453 aa)
GK5Glycerol kinase 5; Belongs to the FGGY kinase family. (533 aa)
INSIG2Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity). (225 aa)
SLC22A4Solute carrier family 22 member 4. (553 aa)
MOGAT2Monoacylglycerol O-acyltransferase 2. (337 aa)
DGKIDiacylglycerol kinase. (1110 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa)
APOBApolipoprotein B-100. (4573 aa)
APOBRUncharacterized protein. (1283 aa)
DGKADiacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (785 aa)
LOC110259135Uncharacterized protein. (340 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PLCE1Phosphoinositide phospholipase C. (2316 aa)
FAAHFatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. (579 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (574 aa)
CPS1Carbamoyl-phosphate synthase 1. (1425 aa)
DGAT2Uncharacterized protein. (339 aa)
DGKBDiacylglycerol kinase. (802 aa)
A0A287BD08_PIGUncharacterized protein; Belongs to the FGGY kinase family. (526 aa)
SLC27A5Solute carrier family 27 member 5. (710 aa)
LIPEHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa)
DGAT2L6Diacylglycerol O-acyltransferase 2 like 6. (337 aa)
GPAT3Glycerol-3-phosphate acyltransferase 3. (438 aa)
PNPLA4-2Patatin like phospholipase domain containing 4. (256 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (486 aa)
PLA2G4APhospholipase A2. (758 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
DGKQDiacylglycerol kinase. (987 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
ABHD16AAbhydrolase domain containing 16A. (579 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ANGRibonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family. (177 aa)
LPIN1Lipin 1. (957 aa)
APOA2Apolipoprotein A-II preproprotein. (100 aa)
DGAT1Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (665 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
PNPLA1Patatin like phospholipase domain containing 1. (501 aa)
APOBEC1Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (236 aa)
GPAT4PlsC domain-containing protein. (457 aa)
LIPCLipase C, hepatic type. (501 aa)
F1SU50_PIGUncharacterized protein. (722 aa)
MTTPMicrosomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
NKX2-3NK2 homeobox 3. (367 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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