54 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGGY	FGGY carbohydrate kinase domain containing. (559 aa)
	DGAT1	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (665 aa)
	LPIN1	Lipin 1. (957 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	APOC3	Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
	SLC37A4	Solute carrier family 37 member 4. (451 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (486 aa)
	PNPLA4-2	Patatin like phospholipase domain containing 4. (256 aa)
	GPAT3	Glycerol-3-phosphate acyltransferase 3. (438 aa)
	LIPE	Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa)
	SLC27A5	Solute carrier family 27 member 5. (710 aa)
	A0A287BD08_PIG	Uncharacterized protein; Belongs to the FGGY kinase family. (526 aa)
	DGAT2	Uncharacterized protein. (339 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1425 aa)
	PNLIPRP2	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (574 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	LOC110259135	Uncharacterized protein. (340 aa)
	APOBR	Uncharacterized protein. (1283 aa)
	APOB	Apolipoprotein B-100. (4573 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa)
	SLC22A4	Solute carrier family 22 member 4. (553 aa)
	INSIG2	Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity). (225 aa)
	GK5	Glycerol kinase 5; Belongs to the FGGY kinase family. (533 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (308 aa)
	MGLL	Monoglyceride lipase. (456 aa)
	LMF1	Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (565 aa)
	LPIN2	Lipin 2. (937 aa)
	CAV3	Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
	LIPI	Lipase I. (480 aa)
	TNXB	Uncharacterized protein. (4137 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (841 aa)
	APOH	Beta-2-glycoprotein 1. (345 aa)
	LIPG	Lipase G, endothelial type. (501 aa)
	PNPLA3	Patatin like phospholipase domain containing 3. (441 aa)
	GPAT2	PlsC domain-containing protein. (800 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (678 aa)
	DDHD2	Phospholipase DDHD2 isoform 1. (715 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (550 aa)
	PNPLA2	Patatin-like phospholipase domain-containing protein 2 isoform X1. (486 aa)
	GK	Uncharacterized protein; Belongs to the FGGY kinase family. (590 aa)
	PNPLA4	PNPLA domain-containing protein. (320 aa)
	LIPH	Lipase H. (451 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (825 aa)
	NKX2-3	NK2 homeobox 3. (367 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
	MTTP	Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa)
	F1SU50_PIG	Uncharacterized protein. (722 aa)
	LPIN3	LNS2 domain-containing protein. (826 aa)
	GPAT4	PlsC domain-containing protein. (457 aa)
	LIPC	Lipase C, hepatic type. (501 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
	PNPLA1	Patatin like phospholipase domain containing 1. (501 aa)
	APOBEC1	Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (236 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287BD08_PIG	GK	ENSSSCP00000054003	ENSSSCP00000012989	Uncharacterized protein; Belongs to the FGGY kinase family.	Uncharacterized protein; Belongs to the FGGY kinase family.	0.801
APOB	APOBEC1	ENSSSCP00000042786	ENSSSCP00000000709	Apolipoprotein B-100.	Apolipoprotein B mRNA editing enzyme catalytic subunit 1.	0.800
APOB	APOBR	ENSSSCP00000042786	ENSSSCP00000043195	Apolipoprotein B-100.	Uncharacterized protein.	0.406
APOB	APOC3	ENSSSCP00000042786	ENSSSCP00000063050	Apolipoprotein B-100.	Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...]	0.987
APOB	APOE	ENSSSCP00000042786	ENSSSCP00000003343	Apolipoprotein B-100.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.988
APOB	APOH	ENSSSCP00000042786	ENSSSCP00000028834	Apolipoprotein B-100.	Beta-2-glycoprotein 1.	0.858
APOB	DGAT1	ENSSSCP00000042786	ENSSSCP00000073101	Apolipoprotein B-100.	Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.	0.559
APOB	DGAT2	ENSSSCP00000042786	ENSSSCP00000051058	Apolipoprotein B-100.	Uncharacterized protein.	0.438
APOB	LIPC	ENSSSCP00000042786	ENSSSCP00000004953	Apolipoprotein B-100.	Lipase C, hepatic type.	0.924
APOB	LIPG	ENSSSCP00000042786	ENSSSCP00000027699	Apolipoprotein B-100.	Lipase G, endothelial type.	0.715
APOB	LOC110259135	ENSSSCP00000042786	ENSSSCP00000045162	Apolipoprotein B-100.	Uncharacterized protein.	0.438
APOB	LPL	ENSSSCP00000042786	ENSSSCP00000057312	Apolipoprotein B-100.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family.	0.540
APOB	MTTP	ENSSSCP00000042786	ENSSSCP00000009789	Apolipoprotein B-100.	Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.	0.990
APOB	PCSK9	ENSSSCP00000042786	ENSSSCP00000023105	Apolipoprotein B-100.	Proprotein convertase subtilisin/kexin type 9.	0.877
APOB	PTPN11	ENSSSCP00000042786	ENSSSCP00000064345	Apolipoprotein B-100.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.552
APOBEC1	APOB	ENSSSCP00000000709	ENSSSCP00000042786	Apolipoprotein B mRNA editing enzyme catalytic subunit 1.	Apolipoprotein B-100.	0.800
APOBR	APOB	ENSSSCP00000043195	ENSSSCP00000042786	Uncharacterized protein.	Apolipoprotein B-100.	0.406
APOBR	LPIN2	ENSSSCP00000043195	ENSSSCP00000033369	Uncharacterized protein.	Lipin 2.	0.472
APOC3	APOB	ENSSSCP00000063050	ENSSSCP00000042786	Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...]	Apolipoprotein B-100.	0.987
APOC3	APOE	ENSSSCP00000063050	ENSSSCP00000003343	Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...]	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.973