STRINGSTRING
ELOVL1 ELOVL1 ST3GAL2 ST3GAL2 B4GALT5 B4GALT5 FUT7 FUT7 GLA GLA TLCD3B TLCD3B CERS6 CERS6 ST8SIA4 ST8SIA4 DEGS2 DEGS2 SGPL1 SGPL1 B4GALT6 B4GALT6 GBA3 GBA3 SPTSSB SPTSSB B4GALT4 B4GALT4 B3GALT2 B3GALT2 SAMD8 SAMD8 F1RK65_PIG F1RK65_PIG P2RX7 P2RX7 SPTLC1 SPTLC1 SPTLC3 SPTLC3 GBA GBA B4GALT3 B4GALT3 ST3GAL1 ST3GAL1 SMPD5 SMPD5 SMPD4 SMPD4 SGMS2 SGMS2 CLN8 CLN8 ST6GALNAC6 ST6GALNAC6 GBA2 GBA2 CLN6 CLN6 CERS3 CERS3 SMPD2 SMPD2 FA2H FA2H B3GALT4 B3GALT4 NEU1 NEU1 B4GALNT1 B4GALNT1 ORMDL2 ORMDL2 CERK CERK ABCA12 ABCA12 UGT8 UGT8 ACER1 ACER1 GAL3ST1 GAL3ST1 TM9SF2 TM9SF2 ASAH2 ASAH2 P2RX1 P2RX1 PLPP2 PLPP2 AGK AGK ST6GALNAC5 ST6GALNAC5 PLPP3 PLPP3 GM2A GM2A C17H20orf173 C17H20orf173 CERS4 CERS4 HEXB HEXB SMPD1 SMPD1 ORMDL1 ORMDL1 NEU2 NEU2 PLPP1 PLPP1 ALOX12B ALOX12B ALOXE3 ALOXE3 GALC GALC CERT1 CERT1 CYP4F22 CYP4F22 DEGS1 DEGS1 UGCG UGCG CERS5 CERS5 ST6GALNAC3 ST6GALNAC3 CEL CEL CERS2 CERS2 NEU3 NEU3 ST6GALNAC4 ST6GALNAC4 ST8SIA3 ST8SIA3 ACER2 ACER2 HEXA HEXA TMEM130 TMEM130 ORMDL3 ORMDL3 LOC100514465 LOC100514465 SPTLC2 SPTLC2 NEU4 NEU4 ST3GAL3 ST3GAL3 ST8SIA2 ST8SIA2 ITGB8 ITGB8 NAGA NAGA SMPD3 SMPD3 ACER3 ACER3 SGMS1 SGMS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa)
ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (350 aa)
B4GALT5Beta-1,4-galactosyltransferase 5; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity). (503 aa)
FUT7Alpha-(1,3)-fucosyltransferase 7. (342 aa)
GLAAlpha-galactosidase. (433 aa)
TLCD3BTLC domain containing 3B. (223 aa)
CERS6Ceramide synthase 6. (392 aa)
ST8SIA4Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (325 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (341 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (609 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (383 aa)
GBA3Glucosylceramidase beta 3 (gene/pseudogene); Belongs to the glycosyl hydrolase 1 family. (469 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (110 aa)
B4GALT4Beta-1,4-galactosyltransferase 4 isoform X1. (344 aa)
B3GALT2Hexosyltransferase. (422 aa)
SAMD8Sterile alpha motif domain containing 8. (478 aa)
F1RK65_PIGUncharacterized protein. (93 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (548 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa)
B4GALT3Beta-1,4-galactosyltransferase 3. (402 aa)
ST3GAL1CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; Responsible for the synthesis of the sequence NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. The short isoform seems to be catalytically inactive. Belongs to the glycosyltransferase 29 family. (343 aa)
SMPD5Endo/exonuclease/phosphatase domain-containing protein. (486 aa)
SMPD4Sphingomyelin phosphodiesterase 4 isoform 2. (868 aa)
SGMS2Phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1. (365 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (416 aa)
ST6GALNAC6Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (265 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (915 aa)
CLN6CLN6 transmembrane ER protein. (312 aa)
CERS3Ceramide synthase 3. (385 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa)
B3GALT4Hexosyltransferase. (377 aa)
NEU1Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity). (432 aa)
B4GALNT1Beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X5. (671 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
CERKCeramide kinase. (536 aa)
ABCA12ATP binding cassette subfamily A member 12. (2593 aa)
UGT8UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (556 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
GAL3ST1Galactose-3-O-sulfotransferase 1. (423 aa)
TM9SF2Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (663 aa)
ASAH2Neutral ceramidase. (786 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (458 aa)
PLPP2Phospholipid phosphatase 2. (368 aa)
AGKAcylglycerol kinase, mitochondrial isoform X1. (421 aa)
ST6GALNAC5ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (407 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
GM2AGanglioside GM2 activator isoform X1. (193 aa)
C17H20orf173Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (336 aa)
CERS4Ceramide synthase 4. (393 aa)
HEXBBeta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (538 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
NEU2Neuraminidase 2. (379 aa)
PLPP1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (698 aa)
ALOXE3Arachidonate lipoxygenase 3. (710 aa)
GALCGalactocerebrosidase isoform a. (685 aa)
CERT1Ceramide transporter 1. (562 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
DEGS1Sphingolipid delta(4)-desaturase DES1 isoform 1. (323 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
CERS5Ceramide synthase 5 isoform X1. (392 aa)
ST6GALNAC3ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (305 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (585 aa)
CERS2Ceramide synthase 2 isoform X1. (524 aa)
NEU3Neuraminidase 3. (428 aa)
ST6GALNAC4ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (366 aa)
ST8SIA3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (485 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa)
HEXABeta-hexosaminidase. (545 aa)
TMEM130Transmembrane protein 130. (342 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (173 aa)
LOC100514465Uncharacterized protein. (371 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
NEU4Neuraminidase 4. (471 aa)
ST3GAL3CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family. (374 aa)
ST8SIA2Alpha-2,8-sialyltransferase 8B isoform 1; Belongs to the glycosyltransferase 29 family. (375 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (722 aa)
NAGAAlpha-galactosidase. (406 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (324 aa)
SGMS1Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell [...] (418 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.