STRINGSTRING
PRAM1 PRAM1 ITGB3 ITGB3 ITGB4 ITGB4 NRP1 NRP1 PLPP3 PLPP3 PLEK PLEK VAV3 VAV3 ITGA1 ITGA1 PTPN11 PTPN11 FERMT2 FERMT2 NME2 NME2 FERMT3 FERMT3 ABL1 ABL1 PTPRA PTPRA ITGA11 ITGA11 THY1 THY1 ITGA5 ITGA5 FUT8 FUT8 FGR FGR LAMA3 LAMA3 ADAM15 ADAM15 FERMT1 FERMT1 ITGAM ITGAM ITGAL ITGAL CIB4 CIB4 TXK TXK TEC TEC PTK2B PTK2B ITGA8 ITGA8 ITGA9 ITGA9 CTNNA1 CTNNA1 ZYX ZYX ITGA2 ITGA2 CD40LG CD40LG ILK ILK SEMA7A SEMA7A FYB2 FYB2 BCAR1 BCAR1 ITGBL1 ITGBL1 ITGB5 ITGB5 ITGB8 ITGB8 RCC2 RCC2 ITGB2 ITGB2 TSPAN32 TSPAN32 ITGB6 ITGB6 ITGB7 ITGB7 ITGA4 ITGA4 TLN1 TLN1 A0A287AB18_PIG A0A287AB18_PIG ISG15 ISG15 PTN PTN ITFG1 ITFG1 ITGA10 ITGA10 CUL3 CUL3 ZNF304 ZNF304 CCN2 CCN2 MADCAM1 MADCAM1 ITGA7 ITGA7 MPIG6B MPIG6B CDH17 CDH17 ITGB1BP1 ITGB1BP1 VAV1 VAV1 APOA1 APOA1 COL3A1 COL3A1 SYK SYK LIMS2 LIMS2 ITGAE ITGAE ITGA6 ITGA6 ITGAV ITGAV ITGB1 ITGB1 SRC SRC FYB1 FYB1 ITGA3 ITGA3 ITGB1BP2 ITGB1BP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRAM1PML-RARA regulated adaptor molecule 1. (689 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
ITGB4Integrin beta. (1814 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
PLEKPleckstrin. (408 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FERMT2Fermitin family member 2. (776 aa)
NME2Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] (404 aa)
FERMT3Fermitin family member 3. (667 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
PTPRAProtein tyrosine phosphatase receptor type A. (850 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1282 aa)
THY1Thy-1 cell surface antigen. (165 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1057 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. (581 aa)
FGRTyrosine-protein kinase. (537 aa)
LAMA3Laminin subunit alpha 3. (3345 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein. (866 aa)
FERMT1Fermitin family member 1. (676 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1272 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1235 aa)
CIB4Calcium and integrin binding family member 4. (185 aa)
TXKTyrosine-protein kinase. (551 aa)
TECTyrosine-protein kinase. (632 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
CTNNA1Catenin alpha 1. (1090 aa)
ZYXZyxin. (588 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
ILKIntegrin linked kinase. (479 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (615 aa)
FYB2FYN binding protein 2. (802 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
ITGBL1Integrin subunit beta like 1. (507 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (722 aa)
RCC2Regulator of chromosome condensation 2. (554 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (903 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (239 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (854 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (882 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1055 aa)
TLN1Talin 1. (2558 aa)
A0A287AB18_PIGUncharacterized protein. (385 aa)
ISG15Ubiquitin-like modifier. (167 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
ITFG1Integrin alpha FG-GAP repeat containing 1. (653 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa)
CUL3Cullin 3; Belongs to the cullin family. (773 aa)
ZNF304Zinc finger protein 304 isoform 2. (661 aa)
CCN2CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
MADCAM1Mucosal addressin cell adhesion molecule 1 isoform a. (390 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1169 aa)
MPIG6BIg-like domain-containing protein. (328 aa)
CDH17Cadherin-17. (832 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (270 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (357 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1168 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
SRCTyrosine-protein kinase. (559 aa)
FYB1FYN binding protein 1. (837 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa)
ITGB1BP2Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells. (342 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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