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POU5F1 POU5F1 SRF SRF MESP1 MESP1 MESP2 MESP2 IRX3 IRX3 GPI GPI ETV2 ETV2 EPHA2 EPHA2 CITED2 CITED2 SMAD4 SMAD4 BMP4 BMP4 LOC100359361 LOC100359361 CRB2 CRB2 FOXH1 FOXH1 EXT1 EXT1 TBX19 TBX19 BMP7 BMP7 SIX2 SIX2 SFRP2 SFRP2 TBX3 TBX3 HNF1A HNF1A NF2 NF2 LDB1 LDB1 ITGA8 ITGA8 POGLUT1 POGLUT1 POFUT2 POFUT2 ZIC3 ZIC3 EXT2 EXT2 PPP2CA PPP2CA SHH SHH EXOC4 EXOC4 SMO SMO HOXA11 HOXA11 ITGA2 ITGA2 CTDNEP1 CTDNEP1 WNT11 WNT11 TLX2 TLX2 LOC100625034 LOC100625034 WNT3A WNT3A TAF10 TAF10 MSGN1 MSGN1 ITGA3 ITGA3 KDM6A KDM6A ITGB1 ITGB1 LHX1 LHX1 SMAD1 SMAD1 YAP1 YAP1 LEF1 LEF1 TEAD2 TEAD2 TCF15 TCF15 PRKACA PRKACA TGFB2 TGFB2 OSR1 OSR1 EOMES EOMES TAL1 TAL1 LHX2 LHX2 EPB41L5 EPB41L5 WNT5A WNT5A EYA1 EYA1 BMPR1A BMPR1A HAND1 HAND1 FOXF1 FOXF1 NUP133 NUP133 PRKAR1A PRKAR1A WNT3 WNT3 NODAL NODAL TBXT TBXT SNAI1 SNAI1 SCX SCX ARMC5 ARMC5 TBX6 TBX6 INHBA INHBA APELA APELA SETD2 SETD2 POU4F1 POU4F1 NOG NOG NANOG NANOG OVOL1 OVOL1 SSBP3 SSBP3 KDM6B KDM6B AMH AMH ZFP36L1 ZFP36L1 HMGA2 HMGA2 TP63 TP63 DLL3 DLL3 FGF8 FGF8 ACVR2B ACVR2B TWSG1 TWSG1 ITGB4 ITGB4 BMPR2 BMPR2 ITGB3 ITGB3 AXIN1 AXIN1 SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
SRFSerum response factor. (512 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (371 aa)
IRX3Iroquois-class homeodomain protein IRX-3 isoform X2. (502 aa)
GPIGlucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). (558 aa)
ETV2ETS variant 2. (242 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LOC100359361Uncharacterized protein. (108 aa)
CRB2Crumbs cell polarity complex component 2. (1283 aa)
FOXH1Forkhead box H1. (354 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TBX19T-box transcription factor TBX19. (446 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
SIX2SIX homeobox 2. (296 aa)
SFRP2Uncharacterized protein. (294 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
HNF1AHepatocyte nuclear factor 1-alpha isoform 2. (631 aa)
NF2Neurofibromin 2. (586 aa)
LDB1LID domain-containing protein. (411 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
POGLUT1Protein O-glucosyltransferase 1 isoform X1. (392 aa)
POFUT2Uncharacterized protein. (789 aa)
ZIC3Zic family member 3. (467 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (688 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
EXOC4Exocyst complex component 4 tv1. (975 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
TLX2T cell leukemia homeobox 2. (283 aa)
LOC100625034Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (327 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (217 aa)
MSGN1Mesogenin 1. (194 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa)
KDM6ALysine demethylase 6A. (1400 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
LHX1LIM homeobox 1. (436 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
YAP1Yes associated protein 1. (432 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
TEAD2TEA domain transcription factor 2. (457 aa)
TCF15Transcription factor 15. (197 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
EOMESEomesodermin. (704 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
FOXF1Forkhead box protein F1. (423 aa)
NUP133Nucleoporin 133. (1160 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (433 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
NODALNodal growth differentiation factor. (316 aa)
TBXTT-box transcription factor T. (435 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (310 aa)
ARMC5Armadillo repeat containing 5. (963 aa)
TBX6T-box transcription factor TBX6 isoform X1. (436 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa)
APELAUncharacterized protein. (54 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2557 aa)
POU4F1POU domain protein. (421 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NANOGHomeobox domain-containing protein. (304 aa)
OVOL1Ovo like transcriptional repressor 1. (313 aa)
SSBP3Single stranded DNA binding protein 3. (388 aa)
KDM6BLysine demethylase 6B. (1638 aa)
AMHMuellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). (577 aa)
ZFP36L1ZFP36 ring finger protein like 1. (348 aa)
HMGA2Uncharacterized protein. (143 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
ITGB4Integrin beta. (1814 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
AXIN1Axin 1. (867 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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