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| | QRFP | Pyroglutamylated RFamide peptide. (134 aa) |
| | FGB | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (534 aa) |
| | NPY1R | Neuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (383 aa) |
| | SLIT2 | Slit guidance ligand 2. (1542 aa) |
| | DRD5 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (471 aa) |
| | ID2 | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa) |
| | ADRA2B | Alpha-2B adrenergic receptor. (446 aa) |
| | UMOD | Uromodulin. (642 aa) |
| | MYL10 | Myosin light chain 10. (167 aa) |
| | AVP | Vasopressin-neurophysin 2-copeptin. (217 aa) |
| | ADRA1D | Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. (570 aa) |
| | MKKS | McKusick-Kaufman syndrome. (570 aa) |
| | KCND3 | Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa) |
| | CASQ2 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (405 aa) |
| | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1028 aa) |
| | NPR1 | Guanylate cyclase. (1057 aa) |
| | F5 | Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. (2258 aa) |
| | CHD7 | Chromodomain helicase DNA binding protein 7. (2863 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | DBH | Dopamine beta-hydroxylase. (610 aa) |
| | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (352 aa) |
| | CORO2B | Coronin; Belongs to the WD repeat coronin family. (554 aa) |
| | ACTC1 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa) |
| | LOC102158424 | Uncharacterized protein; Belongs to the actin family. (466 aa) |
| | SCN5A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1887 aa) |
| | GRK2 | G protein-coupled receptor kinase 2. (778 aa) |
| | APLN | Apelin. (77 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa) |
| | VAMP2 | V-SNARE coiled-coil homology domain-containing protein. (189 aa) |
| | RYR2 | Ryanodine receptor 2. (4966 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa) |
| | MYH7 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa) |
| | STK39 | Serine/threonine kinase 39. (582 aa) |
| | F11R | Uncharacterized protein. (347 aa) |
| | HTR1D | 5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] (377 aa) |
| | GLP1R | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (468 aa) |
| | KNG1 | Kininogen 1. (630 aa) |
| | AGTRAP | Uncharacterized protein. (270 aa) |
| | HTR7 | 5-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (475 aa) |
| | TRDN | Triadin. (729 aa) |
| | PKP2 | Plakophilin 2. (837 aa) |
| | SMTNL2 | Smoothelin like 2. (457 aa) |
| | LOC100515049 | Angiotensin-converting enzyme. (771 aa) |
| | EDN3 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (231 aa) |
| | BBS4 | Uncharacterized protein. (826 aa) |
| | LNPEP | Uncharacterized protein. (1120 aa) |
| | SLC4A5 | Anion exchange protein. (1111 aa) |
| | FERMT2 | Fermitin family member 2. (776 aa) |
| | TNNI3 | Troponin I3, cardiac type. (273 aa) |
| | ANPEP | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] (1017 aa) |
| | ENPEP | Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family. (944 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | IMMP2L | Mitochondrial inner membrane protease subunit. (176 aa) |
| | HTR1B | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (405 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (924 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (744 aa) |
| | P2RX1 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (458 aa) |
| | GSK3A | Protein kinase domain-containing protein. (566 aa) |
| | C2CD4B | Uncharacterized protein. (372 aa) |
| | GATA6 | Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa) |
| | ECE1 | Endothelin converting enzyme 1. (771 aa) |
| | NPPA | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | ARHGAP35 | Rho GTPase-activating protein 35. (1500 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa) |
| | TAC3 | Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family. (126 aa) |
| | OLR1 | Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includin [...] (272 aa) |
| | GCLC | Glutamate--cysteine ligase catalytic subunit isoform X3. (588 aa) |
| | FFAR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (566 aa) |
| | EMILIN1 | Elastin microfibril interfacer 1. (1292 aa) |
| | VSTM4 | V-set and transmembrane domain containing 4. (382 aa) |
| | CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa) |
| | KCNJ2 | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa) |
| | FGFBP3 | Fibroblast growth factor binding protein 3. (256 aa) |
| | C2CD4C | C2 calcium dependent domain containing 4C. (420 aa) |
| | SCN3B | Sodium voltage-gated channel beta subunit 3. (307 aa) |
| | SCN1A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa) |
| | NOS1 | Nitric oxide synthase 1. (1468 aa) |
| | DOCK4 | Dedicator of cytokinesis 4; Belongs to the DOCK family. (1977 aa) |
| | ACTA1 | Actin, alpha skeletal muscle. (465 aa) |
| | SMTNL1 | Calponin-homology (CH) domain-containing protein. (182 aa) |
| | CORO2A | Coronin; Belongs to the WD repeat coronin family. (505 aa) |
| | KLK1 | Glandular kallikrein; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (263 aa) |
| | BMP6 | TGF_BETA_2 domain-containing protein. (537 aa) |
| | ACTG2 | Actin gamma 2, smooth muscle. (417 aa) |
| | GCH1 | GTP cyclohydrolase 1 isoform 1. (249 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1862 aa) |
| | NDST2 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1. (883 aa) |
| | UTS2B | Urotensin 2B. (119 aa) |
| | ZDHHC21 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa) |
| | TJP2 | Uncharacterized protein; Belongs to the MAGUK family. (1187 aa) |
| | SERPINF2 | Alpha-2-antiplasmin isoform X2; Belongs to the serpin family. (563 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PLEC | Plectin. (5422 aa) |
| | CACNA2D1 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1110 aa) |
| | MYLK3 | Myosin light chain kinase 3. (797 aa) |
| | KCNJ8 | Potassium voltage-gated channel subfamily J member 8. (424 aa) |
| | UTS2 | Urotensin-2; Highly potent vasoconstrictor. (121 aa) |
| | KLF2 | Kruppel-like factor 2. (357 aa) |
| | KCNE5 | Potassium voltage-gated channel subfamily E regulatory subunit 5. (145 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1425 aa) |
| | AVPR2 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). (414 aa) |
| | PPP1R13L | Protein phosphatase 1 regulatory subunit 13 like. (797 aa) |
| | DDAH1 | Dimethylarginine dimethylaminohydrolase 1. (324 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | ADH5 | S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (392 aa) |
| | ADRB2 | Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa) |
| | RANGRF | Ran guanine nucleotide release factor isoform A. (182 aa) |
| | UTS2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | GAS6 | Uncharacterized protein. (682 aa) |
| | GPR4 | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. (363 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa) |
| | KCNE3 | Potassium voltage-gated channel subfamily E member 3 isoform X1. (99 aa) |
| | KCNK6 | Potassium two pore domain channel subfamily K member 6; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (495 aa) |
| | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (771 aa) |
| | P2RX2 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (459 aa) |
| | TNNI2 | Uncharacterized protein. (249 aa) |
| | TRPM4 | Transient receptor potential cation channel subfamily M member 4 isoform X1. (1213 aa) |
| | ADRA1A | Alpha-1A adrenergic receptor isoform 1. (466 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (611 aa) |
| | REN | Renin preproprotein; Belongs to the peptidase A1 family. (407 aa) |
| | RHOA | Transforming protein RhoA isoform 1. (193 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (489 aa) |
| | TRHDE | Thyrotropin releasing hormone degrading enzyme. (1066 aa) |
| | CACNB2 | Calcium voltage-gated channel auxiliary subunit beta 2. (656 aa) |
| | PTGS1 | Prostaglandin G/H synthase 1 isoform 1. (600 aa) |
| | CHRM3 | Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (590 aa) |
| | NPR3 | Atrial natriuretic peptide receptor 3 isoform X1. (535 aa) |
| | OCLN | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (533 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | RASL10B | RAS like family 10 member B. (203 aa) |
| | GNA12 | G protein subunit alpha 12. (382 aa) |
| | TNNC1 | Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (184 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1274 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (325 aa) |
| | SCN1B | Sodium voltage-gated channel beta subunit 1. (273 aa) |
| | CORIN | Corin, serine peptidase. (1113 aa) |
| | P2RY2 | P2Y purinoceptor 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP > ATP. (373 aa) |
| | PRKG1 | cGMP-dependent protein kinase. (686 aa) |
| | TCAP | Uncharacterized protein. (262 aa) |
| | CTNNBIP1 | Beta-catenin-interacting protein 1. (81 aa) |
| | NKX2-5 | NK2 homeobox 5. (323 aa) |
| | ABCC9 | ATP binding cassette subfamily C member 9. (1603 aa) |
| | NPY | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (169 aa) |
| | CACNA1C | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1291 aa) |
| | TJP3 | Tight junction protein 3; Belongs to the MAGUK family. (1024 aa) |
| | GCLM | Glutamate--cysteine ligase regulatory subunit. (274 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | NUP155 | Nucleoporin 155. (1391 aa) |
| | GSN | Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Belongs to the villin/gelsolin family. (780 aa) |
| | ASIC2 | Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (564 aa) |
| | ATP2B1 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa) |
| | KCNH2 | Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (1163 aa) |
| | EDN2 | Endothelin 2. (180 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa) |
| | TBXA2R | Thromboxane A2 receptor. (343 aa) |
| | RGS2 | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF [...] (212 aa) |
| | E2F4 | E2F transcription factor 4. (468 aa) |
| | FLI1 | Fli-1 proto-oncogene, ETS transcription factor. (480 aa) |
| | P2RX4 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa) |
| | GPR37L1 | G protein-coupled receptor 37 like 1. (459 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa) |
| | PTP4A3 | Protein tyrosine phosphatase 4A3. (173 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2. (604 aa) |
| | F2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (441 aa) |
| | SGCZ | Sarcoglycan zeta. (312 aa) |
| | ITGB1BP1 | Integrin subunit beta 1 binding protein 1. (270 aa) |
| | MYL2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa) |
| | SPX | Spexin hormone. (118 aa) |
| | KCNE4 | Potassium voltage-gated channel subfamily E regulatory subunit 4. (191 aa) |
| | SCPEP1 | Carboxypeptidase; Belongs to the peptidase S10 family. (514 aa) |
| | STAT1 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa) |
| | SMAD5 | Mothers against decapentaplegic homolog. (465 aa) |
| | KCNMA1 | Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1288 aa) |
| | LOC100152206 | Uncharacterized protein. (319 aa) |
| | SCN2B | Sodium voltage-gated channel beta subunit 2. (222 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | OXTR | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (374 aa) |
| | TNNI1 | Troponin I1, slow skeletal type. (228 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | NOX1 | NADPH oxidase 1 isoform 1. (564 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (482 aa) |
| | ERAP1 | Aminopeptidase. (922 aa) |
| | ACE2 | Angiotensin-converting enzyme. (805 aa) |
| | NCALD | Neurocalcin delta. (200 aa) |
| | C2CD4D | C2 calcium dependent domain containing 4D. (353 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (727 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | TNNT2 | Uncharacterized protein. (295 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (155 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa) |
| | PDE2A | Phosphodiesterase. (1010 aa) |
| | SUCNR1 | Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | BDKRB2 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (440 aa) |
| | RNLS | Renalase, FAD dependent amine oxidase. (342 aa) |
| | FGG | Fibrinogen gamma chain. (454 aa) |
| | SCN4B | Ig-like domain-containing protein. (480 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (644 aa) |
| | ADRA2C | Adrenoceptor alpha 2C. (460 aa) |
| | PTPRO | Protein tyrosine phosphatase receptor type O. (1186 aa) |
| | PTPRJ | Protein tyrosine phosphatase receptor type J. (1340 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | DRD1 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa) |
| | KCNJ5 | G protein-activated inward rectifier potassium channel 4; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. (419 aa) |
| | ERAP2 | Aminopeptidase. (951 aa) |
| | ADORA2B | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa) |
| | HRH2 | Histamine H2 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (423 aa) |
| | GNA11 | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (By similarity). (359 aa) |
| | COX2 | Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (229 aa) |
| | COX1 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa) |
| | MYL4 | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. (197 aa) |
| | ACE | Angiotensin-converting enzyme. (1309 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa) |
| | GAA | Glucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (937 aa) |
| | SGCD | Sarcoglycan delta. (290 aa) |
| | ADRA1B | Adrenoceptor alpha 1B. (518 aa) |
| | CARTPT | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. Belongs to the CART family. (116 aa) |
| | TBX20 | T-box transcription factor TBX20 isoform 1. (449 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (481 aa) |
| | ADRB3 | Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. (407 aa) |
| | AVPR1B | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa) |
| | COL1A2 | Fibrillar collagen NC1 domain-containing protein. (1135 aa) |
| | ARHGAP42 | Rho GTPase activating protein 42. (871 aa) |
| | PRCP | Prolylcarboxypeptidase. (511 aa) |
| | OR51E2 | Olfactory receptor. (320 aa) |
| | LVRN | Aminopeptidase. (992 aa) |
| | KCNN2 | Small conductance calcium-activated potassium channel protein 2 isoform X1. (851 aa) |
| | GPR150 | G protein-coupled receptor 150. (431 aa) |
| | F2RL1 | Proteinase-activated receptor 2 preproprotein. (397 aa) |
| | COMP | Cartilage oligomeric matrix protein. (756 aa) |
| | ADM | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. (188 aa) |
| | CSRP3 | Uncharacterized protein. (200 aa) |
| | NAV2 | Neuron navigator 2. (2407 aa) |
| | EXT2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (688 aa) |
| | VEGFB | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | AGTR2 | Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | P2RY4 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (365 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa) |
| | KCNE1 | Potassium voltage-gated channel subfamily E member 1. (129 aa) |
| | GRIP2 | Glutamate receptor interacting protein 2. (1044 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2211 aa) |
| | MYL3 | Uncharacterized protein. (196 aa) |
| | ADRB1 | Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (516 aa) |
| | ADRA2A | Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (465 aa) |
| | ACTA2 | Actin alpha 2, smooth muscle. (386 aa) |
| | DOCK5 | Dedicator of cytokinesis 5; Belongs to the DOCK family. (1867 aa) |
| | EDNRB | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa) |
| | EDNRA | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa) |
