STRINGSTRING
HDGF HDGF ABI3BP ABI3BP RTN4R RTN4R THBS2 THBS2 SMOC1 SMOC1 FGF9 FGF9 HBEGF HBEGF TMEM184B TMEM184B FSTL1 FSTL1 FGFBP3 FGFBP3 LPL LPL CCN5 CCN5 FNDC1 FNDC1 CCN6 CCN6 NELL1 NELL1 EFEMP2 EFEMP2 FGF2 FGF2 FURIN FURIN VEGFA VEGFA ADA2 ADA2 CHADL CHADL PRELP PRELP NRP2 NRP2 NELL2 NELL2 SPMI SPMI PDCD5 PDCD5 HDGFL1 HDGFL1 LRTM2 LRTM2 NAV2 NAV2 F2 F2 VEGFB VEGFB ADAMTS5 ADAMTS5 APP APP HRG HRG LIPH LIPH LRRC3B LRRC3B AZU1 AZU1 COL5A3 COL5A3 COMP COMP ADAMTS15 ADAMTS15 MSTN MSTN FN1 FN1 AAMP AAMP FGF10 FGF10 SLIT3 SLIT3 ANXA6 ANXA6 LRRC3C LRRC3C COLQ COLQ THBS4 THBS4 VTN VTN NYX NYX PTPRS PTPRS CDON CDON HSD17B12 HSD17B12 ELANE ELANE LXN LXN GREM2 GREM2 LTF LTF ECM2 ECM2 LIPG LIPG PTCH1 PTCH1 EVA1C EVA1C APOH APOH SFRP1 SFRP1 FGFR1 FGFR1 ALK ALK TNXB TNXB FGFR4 FGFR4 MPO MPO CRISPLD2 CRISPLD2 PTPRF PTPRF GPNMB GPNMB RSPO3 RSPO3 CXCL10 CXCL10 IMPG2 IMPG2 CCL8 CCL8 COL25A1 COL25A1 ADGRG1 ADGRG1 MPIG6B MPIG6B LRTM1 LRTM1 F11 F11 CCN2 CCN2 FGF1 FGF1 AOC1 AOC1 CCDC80 CCDC80 C6orf15 C6orf15 APLP2 APLP2 CXCL13 CXCL13 PTPRC PTPRC PTN PTN RPL22 RPL22 ZNF207 ZNF207 REG4 REG4 CLEC3B CLEC3B APOB APOB FGFRL1 FGFRL1 LRPAP1 LRPAP1 LOC110257188 LOC110257188 THBS3 THBS3 APLP1 APLP1 SAA2 SAA2 SOST SOST RSPO1 RSPO1 SERPINE2 SERPINE2 LRRC70 LRRC70 CCN4 CCN4 SLIT1 SLIT1 POSTN POSTN NDNF NDNF ANXA5 ANXA5 CXCL8 CXCL8 SLIT2 SLIT2 FBLN7 FBLN7 RSPO4 RSPO4 CRISPLD1 CRISPLD1 CCN3 CCN3 PCSK6 PCSK6 COL5A1 COL5A1 BMP4 BMP4 THBS1 THBS1 FBN1 FBN1 LIPC LIPC SMOC2 SMOC2 ELSPBP1 ELSPBP1 BSPH1 BSPH1 APOE APOE BSP1 BSP1 AWN AWN AQN-1 AQN-1 COL13A1 COL13A1 CXCL11 CXCL11 LTBP2 LTBP2 SELP SELP RSPO2 RSPO2 PPBP PPBP TGFBR3 TGFBR3 ADAMTS1 ADAMTS1 BOC BOC NRP1 NRP1 IMPG1 IMPG1 ANG ANG TWSG1 TWSG1 A0A5G2RBJ3_PIG A0A5G2RBJ3_PIG SERPINC1 SERPINC1 CCN1 CCN1 TMEM184A TMEM184A RTN4RL1 RTN4RL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDGFHeparin binding growth factor. (253 aa)
ABI3BPABI family member 3 binding protein. (1668 aa)
RTN4RReticulon 4 receptor. (548 aa)
THBS2Thrombospondin 2. (1223 aa)
SMOC1SPARC related modular calcium binding 1. (469 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
TMEM184BTransmembrane protein 184B. (424 aa)
FSTL1Follistatin like 1. (307 aa)
FGFBP3Fibroblast growth factor binding protein 3. (256 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (486 aa)
CCN5WNT1-inducible-signaling pathway protein 2 isoform 1. (244 aa)
FNDC1Fibronectin type III domain containing 1. (1764 aa)
CCN6WNT1-inducible-signaling pathway protein 3 isoform 3. (354 aa)
NELL1Protein kinase C-binding protein NELL1 isoform 1. (810 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (498 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (797 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa)
ADA2Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). (509 aa)
CHADLChondroadherin like. (760 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (381 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (920 aa)
NELL2Neural EGFL like 2. (826 aa)
SPMISeminal plasma sperm motility inhibitor; Inhibitor of sperm motility. (137 aa)
PDCD5Programmed cell death 5. (165 aa)
HDGFL1Uncharacterized protein. (208 aa)
LRTM2Leucine rich repeats and transmembrane domains 2. (357 aa)
NAV2Neuron navigator 2. (2407 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (929 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa)
HRGUncharacterized protein. (561 aa)
LIPHLipase H. (451 aa)
LRRC3BLeucine-rich repeat-containing protein 3B. (259 aa)
AZU1Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily. (246 aa)
COL5A3Collagen type V alpha 3 chain. (1747 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
ADAMTS15A disintegrin and metalloproteinase with thrombospondin motifs 15 preproprotein. (950 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
FN1Fibronectin 1. (2462 aa)
AAMPAngio associated migratory cell protein. (388 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SLIT3Slit guidance ligand 3. (1523 aa)
ANXA6Annexin. (672 aa)
LRRC3CLeucine rich repeat containing 3C. (254 aa)
COLQCollagen like tail subunit of asymmetric acetylcholinesterase. (458 aa)
THBS4Thrombospondin 4. (976 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
NYXNyctalopin. (494 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1946 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa)
LXNLatexin. (222 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (166 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (704 aa)
ECM2Extracellular matrix protein 2. (696 aa)
LIPGLipase G, endothelial type. (501 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
EVA1CEva-1 homolog C. (442 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ALKUncharacterized protein. (1034 aa)
TNXBUncharacterized protein. (4137 aa)
FGFR4Fibroblast growth factor receptor. (903 aa)
MPOMyeloperoxidase. (731 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (497 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1919 aa)
GPNMBGlycoprotein nmb. (565 aa)
RSPO3Uncharacterized protein. (280 aa)
CXCL10C-X-C motif chemokine. (104 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1244 aa)
CCL8C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
COL25A1Collagen type XXV alpha 1 chain. (695 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (740 aa)
MPIG6BIg-like domain-containing protein. (328 aa)
LRTM1Leucine-rich repeat and transmembrane domain-containing protein 1 isoform 1. (345 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (623 aa)
CCN2CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
FGF1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa)
AOC1Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis; Belongs to the copper/topaquinone oxidase family. (726 aa)
CCDC80Coiled-coil domain containing 80. (1016 aa)
C6orf15Chromosome 6 open reading frame 15. (306 aa)
APLP2Amyloid beta precursor like protein 2. (770 aa)
CXCL13C-X-C motif chemokine. (111 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
RPL2260S ribosomal protein L22. (69 aa)
ZNF207Zinc finger protein 207. (497 aa)
REG4Regenerating islet derived family member 4 variant 2. (158 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
APOBApolipoprotein B-100. (4573 aa)
FGFRL1Fibroblast growth factor receptor like 1. (566 aa)
LRPAP1Alpha-2-macroglobulin receptor-associated protein. (356 aa)
LOC110257188Uncharacterized protein. (65 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
APLP1Amyloid beta precursor like protein 1. (733 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
SOSTSclerostin. (212 aa)
RSPO1R-spondin 1. (262 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
LRRC70Leucine-rich repeat-containing protein 70. (631 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
POSTNPeriostin. (836 aa)
NDNFNeuron derived neurotrophic factor. (664 aa)
ANXA5Annexin. (321 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
FBLN7Fibulin 7. (569 aa)
RSPO4R-spondin 4. (235 aa)
CRISPLD1Cysteine-rich secretory protein LCCL domain-containing 1 isoform 1. (500 aa)
CCN3Cellular communication network factor 3. (398 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. (965 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
THBS1Uncharacterized protein. (1170 aa)
FBN1Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
LIPCLipase C, hepatic type. (501 aa)
SMOC2SPARC related modular calcium binding 2. (613 aa)
ELSPBP1Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity. (223 aa)
BSPH1Binder of sperm protein homolog 1. (127 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
BSP1Seminal plasma protein pB1; May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity. (152 aa)
AWNCarbohydrate-binding protein AWN; AWN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism. Awn proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation. They possess as well heparin-, serine-protease-inhibitor-binding capability. (154 aa)
AQN-1Carbohydrate-binding protein AQN-1; AQN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism. AQN proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation. They possess as well heparin-, serine-protease-inhibitor-binding capability; Belongs to the spermadhesin family. (132 aa)
COL13A1Collagen type XIII alpha 1 chain. (726 aa)
CXCL11C-X-C motif chemokine. (129 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1814 aa)
SELPUncharacterized protein. (671 aa)
RSPO2Uncharacterized protein. (242 aa)
PPBPPlatelet basic protein; Chemoattractant factor for neutrophils. (159 aa)
TGFBR3Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa)
ADAMTS1Peptidase M12B domain-containing protein. (963 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1241 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
IMPG1Interphotoreceptor matrix proteoglycan 1. (787 aa)
ANGRibonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family. (177 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
A0A5G2RBJ3_PIGTyrosine-protein kinase receptor. (542 aa)
SERPINC1SERPIN domain-containing protein; Belongs to the serpin family. (431 aa)
CCN1Cellular communication network factor 1. (382 aa)
TMEM184ATransmembrane protein 184A. (482 aa)
RTN4RL1Reticulon 4 receptor like 1. (518 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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