34 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

gene co-occurrence

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Your Input:
	CCAR2	DBC1 domain-containing protein. (916 aa)
	HK2	Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
	BCL2L11	Uncharacterized protein. (433 aa)
	STPG1	Sperm tail PG-rich repeat containing 1. (335 aa)
	BAX	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
	BBC3	Uncharacterized protein. (361 aa)
	NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (749 aa)
	GGCT	Uncharacterized protein. (188 aa)
	A0A5G2QRP7_PIG	Uncharacterized protein. (104 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (770 aa)
	TIMM50	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (355 aa)
	AIFM2	Apoptosis inducing factor mitochondria associated 2. (415 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
	NOL3	Nucleolar protein 3. (237 aa)
	BID	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa)
	IFI6	Interferon alpha inducible protein 6. (171 aa)
	HSPD1	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (468 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1021 aa)
	BOK	BCL2 family apoptosis regulator BOK. (288 aa)
	BNIP3L	BCL2 interacting protein 3 like. (204 aa)
	BAD	BCL2 associated agonist of cell death. (209 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	GCLM	Glutamate--cysteine ligase regulatory subunit. (274 aa)
	RHOT1	Ras homolog family member T1. (752 aa)
	BCL2L1	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
	BAK1	Uncharacterized protein. (266 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa)
	PMAIP1	Uncharacterized protein. (121 aa)
	BNIP3	BCL2 interacting protein 3. (202 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1201 aa)
	ATG3	Autophagy-related protein 3. (320 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (237 aa)
	VDAC2	Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (294 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5G2QRP7_PIG	BCL2L1	ENSSSCP00000067595	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.406
A0A5G2QRP7_PIG	BNIP3L	ENSSSCP00000067595	ENSSSCP00000044058	Uncharacterized protein.	BCL2 interacting protein 3 like.	0.643
AIFM2	NDUFS1	ENSSSCP00000053862	ENSSSCP00000071617	Apoptosis inducing factor mitochondria associated 2.	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	0.435
ATG3	BNIP3	ENSSSCP00000012711	ENSSSCP00000022131	Autophagy-related protein 3.	BCL2 interacting protein 3.	0.500
BAD	BAK1	ENSSSCP00000042395	ENSSSCP00000032742	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.805
BAD	BCL2L1	ENSSSCP00000042395	ENSSSCP00000033436	BCL2 associated agonist of cell death.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAD	BCL2L11	ENSSSCP00000042395	ENSSSCP00000008657	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.870
BAD	BID	ENSSSCP00000042395	ENSSSCP00000048980	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.736
BAD	BOK	ENSSSCP00000042395	ENSSSCP00000044300	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.751
BAD	TP53	ENSSSCP00000042395	ENSSSCP00000050664	BCL2 associated agonist of cell death.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.408
BAK1	BAD	ENSSSCP00000032742	ENSSSCP00000042395	Uncharacterized protein.	BCL2 associated agonist of cell death.	0.805
BAK1	BAX	ENSSSCP00000032742	ENSSSCP00000003404	Uncharacterized protein.	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	0.901
BAK1	BBC3	ENSSSCP00000032742	ENSSSCP00000070559	Uncharacterized protein.	Uncharacterized protein.	0.768
BAK1	BCL2L1	ENSSSCP00000032742	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAK1	BCL2L11	ENSSSCP00000032742	ENSSSCP00000008657	Uncharacterized protein.	Uncharacterized protein.	0.896
BAK1	BID	ENSSSCP00000032742	ENSSSCP00000048980	Uncharacterized protein.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.993
BAK1	ERBB4	ENSSSCP00000032742	ENSSSCP00000017120	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.526
BAK1	PMAIP1	ENSSSCP00000032742	ENSSSCP00000027713	Uncharacterized protein.	Uncharacterized protein.	0.659
BAK1	TP53	ENSSSCP00000032742	ENSSSCP00000050664	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.978
BAX	BAK1	ENSSSCP00000003404	ENSSSCP00000032742	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Uncharacterized protein.	0.901