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TPI1 TPI1 GPI GPI GAPDHS GAPDHS HK2 HK2 NUDT18 NUDT18 ENTPD7 ENTPD7 ENO4 ENO4 PFKP PFKP UMPS UMPS PGK1 PGK1 PFKFB2 PFKFB2 PRKAG3 PRKAG3 LRGUK LRGUK PGAM2 PGAM2 OGDH OGDH FOXK2 FOXK2 TIGAR TIGAR ENO2 ENO2 B3GAT3 B3GAT3 CAD CAD B3GAT2 B3GAT2 I3LV77_PIG I3LV77_PIG HK3 HK3 NT5E NT5E PFKM PFKM HTR2A HTR2A HKDC1 HKDC1 AK1 AK1 ENO3 ENO3 B3GAT1 B3GAT1 GUK1 GUK1 GAPDH GAPDH AK4 AK4 PKLR PKLR RRM1 RRM1 ENTPD2 ENTPD2 BAD BAD PFKL PFKL RRM2 RRM2 PGAM1 PGAM1 PGK2 PGK2 NUDT16 NUDT16 ENO1 ENO1 GCK GCK A0A287B6L0_PIG A0A287B6L0_PIG ALDOC ALDOC BPGM BPGM ALDOA ALDOA RRM2B RRM2B ENTPD5 ENTPD5 ENTPD4 ENTPD4 NUDT5 NUDT5 GALK1 GALK1 CMPK1 CMPK1 ADPGK ADPGK AK3 AK3 DHODH DHODH A0A5G2QSC8_PIG A0A5G2QSC8_PIG ALDOB ALDOB HK1 HK1 FOXK1 FOXK1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TPI1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (285 aa)
GPIGlucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). (558 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (403 aa)
HK2Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
NUDT18Nudix hydrolase 18; Belongs to the Nudix hydrolase family. (322 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa)
ENO4Enolase 4. (617 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (835 aa)
UMPSUridine monophosphate synthetase. (486 aa)
PGK1Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1. (535 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (499 aa)
LRGUKLeucine rich repeats and guanylate kinase domain containing. (815 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
OGDHOxoglutarate dehydrogenase. (1035 aa)
FOXK2Forkhead box protein K2. (656 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
ENO2Enolase 2. (434 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (339 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2205 aa)
B3GAT2Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (323 aa)
I3LV77_PIGUncharacterized protein. (135 aa)
HK3Hexokinase 3. (890 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (810 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (268 aa)
ENO3Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. (476 aa)
B3GAT1Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (347 aa)
GUK1Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. (242 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (565 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2 isoform 1; Belongs to the GDA1/CD39 NTPase family. (495 aa)
BADBCL2 associated agonist of cell death. (209 aa)
PFKL6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (782 aa)
RRM2Uncharacterized protein. (439 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PGK2Phosphoglycerate kinase 2; Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis. Belongs to the phosphoglycerate kinase family. (417 aa)
NUDT16Nudix hydrolase 16. (211 aa)
ENO1Alpha-enolase isoform X1. (434 aa)
GCKGlucokinase. (659 aa)
A0A287B6L0_PIGUncharacterized protein. (91 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (434 aa)
BPGMPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (532 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (385 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (483 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (605 aa)
NUDT5Nudix hydrolase 5; Belongs to the Nudix hydrolase family. (270 aa)
GALK1Galactokinase 1. (414 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (206 aa)
ADPGKADP dependent glucokinase. (497 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
DHODHDihydroorotate dehydrogenase (quinone). (421 aa)
A0A5G2QSC8_PIGUncharacterized protein. (57 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (366 aa)
HK1Uncharacterized protein. (919 aa)
FOXK1Forkhead box K1. (762 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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