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| | METTL14 | N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa) |
| | FTO | FTO_NTD domain-containing protein. (509 aa) |
| | RAMAC | Uncharacterized protein. (118 aa) |
| | METTL2A | Uncharacterized protein. (444 aa) |
| | TRUB1 | TruB pseudouridine synthase family member 1. (343 aa) |
| | RRNAD1 | Ribosomal RNA adenine dimethylase domain containing 1. (475 aa) |
| | A0A287B0N5_PIG | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (123 aa) |
| | CTU2 | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family. (591 aa) |
| | AARS2 | Alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (1014 aa) |
| | CTU1 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position; Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily. (343 aa) |
| | AARS1 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (967 aa) |
| | LOC100516084 | Uncharacterized protein. (332 aa) |
| | PUSL1 | tRNA pseudouridine synthase. (435 aa) |
| | TRIT1 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (470 aa) |
| | MTO1 | Mitochondrial tRNA translation optimization 1. (691 aa) |
| | MTFMT | Mitochondrial methionyl-tRNA formyltransferase. (390 aa) |
| | TRMT10B | tRNA methyltransferase 10 homolog B isoform a. (316 aa) |
| | VIRMA | Vir like m6A methyltransferase associated. (1812 aa) |
| | RBM15 | RNA binding motif protein 15. (1006 aa) |
| | HENMT1 | HEN methyltransferase 1. (383 aa) |
| | TRMT6 | tRNA methyltransferase 6. (693 aa) |
| | PCIF1 | Phosphorylated CTD-interacting factor 1 isoform X1. (703 aa) |
| | MOCS3 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (455 aa) |
| | NSUN5 | NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa) |
| | RPUSD1 | RNA pseudouridine synthase domain containing 1. (319 aa) |
| | TSR3 | Probable ribosome biogenesis protein C16orf42 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis. (316 aa) |
| | PUS10 | Pseudouridine synthase 10. (531 aa) |
| | THUMPD2 | THUMP domain containing 2. (584 aa) |
| | ADAD1 | Adenosine deaminase domain containing 1. (577 aa) |
| | ZC3H13 | Zinc finger CCCH-type containing 13. (1640 aa) |
| | TRMT2A | tRNA methyltransferase 2 homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (621 aa) |
| | TARBP1 | TAR (HIV-1) RNA binding protein 1. (1613 aa) |
| | DALRD3 | DALR anticodon-binding domain-containing protein 3 isoform 1. (592 aa) |
| | THUMPD3 | THUMP domain-containing protein 3 isoform X1. (503 aa) |
| | RPUSD3 | Mitochondrial mRNA pseudouridine synthase RPUSD3 isoform 1. (352 aa) |
| | DNAJB11 | DnaJ homolog subfamily B member 11. (358 aa) |
| | DKC1 | Uncharacterized protein. (521 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa) |
| | DUS3L | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (652 aa) |
| | QTRT1 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (403 aa) |
| | TRMT1 | tRNA (guanine(26)-N(2))-dimethyltransferase. (660 aa) |
| | C11orf54 | Chromosome 11 open reading frame 54. (315 aa) |
| | PUS3 | tRNA pseudouridine(38/39) synthase isoform 1. (479 aa) |
| | RPUSD4 | RNA pseudouridylate synthase domain-containing protein 4. (376 aa) |
| | PUS7 | Pseudouridine synthase 7. (816 aa) |
| | TYW5 | tRNA wybutosine-synthesizing protein 5. (315 aa) |
| | FBLL1 | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1. (332 aa) |
| | FTSJ3 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (836 aa) |
| | MRM3 | Mitochondrial rRNA methyltransferase 3. (422 aa) |
| | MEPCE | Methylphosphate capping enzyme. (744 aa) |
| | TFB2M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (391 aa) |
| | FBL | Fibrillarin. (321 aa) |
| | ELP2 | Elongator acetyltransferase complex subunit 2. (826 aa) |
| | ANKRD16 | Ankyrin repeat domain-containing protein 16 isoform X1. (363 aa) |
| | ALKBH8 | AlkB homolog 8, tRNA methyltransferase. (614 aa) |
| | WDR4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (416 aa) |
| | FDXACB1 | Ferredoxin-fold anticodon-binding domain-containing protein 1. (625 aa) |
| | METTL1 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (277 aa) |
| | TRMT61B | tRNA methyltransferase 61B. (492 aa) |
| | TRMT1L | tRNA methyltransferase 1 like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (818 aa) |
| | METTL3 | N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (580 aa) |
| | FTSJ1 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (368 aa) |
| | TGS1 | Trimethylguanosine synthase 1. (779 aa) |
| | THUMPD1 | THUMP domain-containing protein 1. (359 aa) |
| | ALKBH1 | AlkB homolog 1, histone H2A dioxygenase. (425 aa) |
| | CBLL1 | Cbl proto-oncogene like 1. (529 aa) |
| | DUS4L | tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (329 aa) |
| | EMG1 | Ribosomal RNA small subunit methyltransferase NEP1 isoform 1. (244 aa) |
| | DTWD2 | DTW domain-containing protein 2 isoform a. (298 aa) |
| | ZCCHC4 | Zinc finger CCHC domain-containing protein 4 isoform 1. (513 aa) |
| | TFB1M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (340 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa) |
| | DTWD1 | DTW domain-containing protein 1 isoform X1. (301 aa) |
| | CDKAL1 | CDK5 regulatory subunit associated protein 1 like 1. (600 aa) |
| | C9orf64 | Queuosine salvage protein; Involved in salvaging queuosine. (385 aa) |
| | TRMT13 | tRNA:m(4)X modification enzyme TRM13 homolog. (481 aa) |
| | PUS7L | Pseudouridine synthase 7 like. (702 aa) |
| | QTRT2 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (482 aa) |
| | TRMT61A | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (285 aa) |
| | MRM2 | FtsJ domain-containing protein. (246 aa) |
| | ALKBH5 | AlkB homolog 5, RNA demethylase. (394 aa) |
| | CMTR2 | Cap methyltransferase 2. (764 aa) |
| | A1CF | APOBEC1 complementation factor isoform 2. (595 aa) |
| | ELP3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (638 aa) |
| | THG1L | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (298 aa) |
| | WTAP | Uncharacterized protein. (649 aa) |
| | BCDIN3D | BCDIN3 domain containing RNA methyltransferase. (302 aa) |
| | DIMT1 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (313 aa) |
| | TYW1 | Flavodoxin-like domain-containing protein. (800 aa) |
| | GTPBP3 | GTP binding protein 3, mitochondrial. (515 aa) |
| | METTL16 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (561 aa) |
| | LOC110258925 | Putative GTP-binding protein 6. (519 aa) |
| | HNRNPAB | Uncharacterized protein. (345 aa) |
| | WDR6 | WD repeat domain 6. (1120 aa) |
| | ELP5 | Elongator acetyltransferase complex subunit 5. (336 aa) |
| | TRMT44 | tRNA methyltransferase 44 homolog. (783 aa) |
| | TRMT10A | tRNA methyltransferase 10A. (401 aa) |
| | JMJD6 | Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (413 aa) |
| | NSUN2 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (992 aa) |
| | ADARB2 | Adenosine deaminase RNA specific B2 (inactive). (734 aa) |
| | TPRKB | TP53RK binding protein; Belongs to the CGI121/TPRKB family. (199 aa) |
| | A0A5G2QJF6_PIG | SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (105 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1169 aa) |
| | NSUN3 | NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (339 aa) |
| | KTI12 | Uncharacterized protein. (354 aa) |
| | YRDC | YrdC N6-threonylcarbamoyltransferase domain containing. (319 aa) |
| | RNMT | mRNA cap guanine-N7 methyltransferase. (477 aa) |
| | METTL6 | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (284 aa) |
| | NAF1 | Nuclear assembly factor 1 ribonucleoprotein. (500 aa) |
| | A0A5G2QWJ3_PIG | Uncharacterized protein. (267 aa) |
| | NSUN6 | NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (598 aa) |
| | TRDMT1 | tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (398 aa) |
| | METTL5 | Methyltransferase like 5. (226 aa) |
| | AICDA | Activation induced cytidine deaminase. (224 aa) |
| | METTL4 | Methyltransferase like 4; Belongs to the MT-A70-like family. (478 aa) |
| | BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor. (372 aa) |
| | ADAT2 | Adenosine deaminase tRNA specific 2. (230 aa) |
| | METTL15 | Methyltransferase like 15. (404 aa) |
| | NDUFA4L2 | NDUFA4 mitochondrial complex associated like 2. (91 aa) |
| | TRMT2B | tRNA methyltransferase 2 homolog B; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (503 aa) |
| | ELP6 | Elongator acetyltransferase complex subunit 6. (332 aa) |
| | ELP1 | Elongator complex protein 1 isoform 1. (1422 aa) |
| | GON7 | EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex. (206 aa) |
| | ADAD2 | Adenosine deaminase domain containing 2. (564 aa) |
| | OSGEP | Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (335 aa) |
| | F1SHL4_PIG | Uncharacterized protein. (247 aa) |
| | CMTR1 | Cap methyltransferase 1. (834 aa) |
| | NOP2 | SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (822 aa) |
| | APOBEC1 | Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (236 aa) |
| | APOBEC3B | Uncharacterized protein. (418 aa) |
| | TRMU | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase. (421 aa) |
| | SNTA1 | Uncharacterized protein. (1071 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (178 aa) |
| | OSGEPL1 | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (414 aa) |
| | TRUB2 | Mitochondrial mRNA pseudouridine synthase TRUB2 isoform 1. (349 aa) |
| | PUS1 | Pseudouridine synthase 1. (433 aa) |
| | APOBEC2 | Apolipoprotein B mRNA editing enzyme catalytic subunit 2. (224 aa) |
| | NOP10 | NOP10 ribonucleoprotein. (64 aa) |
| | NSUN4 | NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (382 aa) |
| | RBM47 | RNA-binding protein 47 isoform X1. (686 aa) |
| | TRMT112 | Multifunctional methyltransferase subunit TRM112-like protein isoform X1. (154 aa) |
| | TRMT5 | tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (504 aa) |
| | TRMT10C | tRNA methyltransferase 10C, mitochondrial RNase P subunit. (415 aa) |
| | TRMT11 | tRNA methyltransferase 11 homolog. (494 aa) |
| | LYRM9 | Uncharacterized protein; Belongs to the complex I LYR family. (103 aa) |
| | ADARB1 | Adenosine deaminase RNA specific B1. (702 aa) |
| | DUS1L | Dihydrouridine synthase 1 like. (474 aa) |
| | TYW3 | tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). (259 aa) |
| | TRMT9B | tRNA methyltransferase 9B (putative). (457 aa) |
| | LOC110257936 | Putative GTP-binding protein 6. (519 aa) |
| | METTL8 | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (426 aa) |
| | ELP4 | Elongator acetyltransferase complex subunit 4. (476 aa) |
| | NUDT16 | Nudix hydrolase 16. (211 aa) |
| | URM1 | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for co [...] (200 aa) |
