STRINGSTRING
GPER1 GPER1 SSTR3 SSTR3 CRHR2 CRHR2 THRA THRA RXRA RXRA TTC6 TTC6 PAQR7 PAQR7 PTPN11 PTPN11 PRLR PRLR NKX3-1 NKX3-1 RXRG RXRG ARID1A ARID1A DDX5 DDX5 NEDD4 NEDD4 LATS2 LATS2 NR5A2 NR5A2 TSHR TSHR ESRRG ESRRG PAQR8 PAQR8 HNF4G HNF4G ESRRB ESRRB SLC27A1 SLC27A1 NR5A1 NR5A1 NR3C1 NR3C1 REN REN RHOA RHOA UCN2 UCN2 LATS1 LATS1 ACSL1 ACSL1 A0A287AAC1_PIG A0A287AAC1_PIG UBE3A UBE3A ABHD2 ABHD2 OSTN OSTN A0A287A514_PIG A0A287A514_PIG TRIP4 TRIP4 APPL1 APPL1 KDM3A KDM3A RARA RARA RXFP1 RXFP1 SSTR5 SSTR5 YAP1 YAP1 RARG RARG DDX17 DDX17 RBFOX2 RBFOX2 ESR1 ESR1 SRC SRC NR3C2 NR3C2 CSNK2B CSNK2B CALCOCO1 CALCOCO1 PHB2 PHB2 PADI2 PADI2 RXFP2 RXFP2 NR1D2 NR1D2 UBR5 UBR5 FSHR FSHR POU4F2 POU4F2 PHB PHB MED1 MED1 SSTR2 SSTR2 OR51E2 OR51E2 PPARGC1B PPARGC1B CRHBP CRHBP SAFB SAFB NR1H3 NR1H3 PHEROC PHEROC ESRRA ESRRA AR AR GHSR GHSR TRH TRH PPARG PPARG TMF1 TMF1 ZMIZ1 ZMIZ1 YWHAH YWHAH LHCGR LHCGR BMP7 BMP7 CST11 CST11 ESR2 ESR2 BMP4 BMP4 AGRP AGRP SSTR1 SSTR1 PPARD PPARD DAXX DAXX RXRB RXRB APPL2 APPL2 ADIPOR2 ADIPOR2 PPARA PPARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (421 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (482 aa)
THRAThyroid hormone receptor alpha; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. (508 aa)
RXRARetinoid X receptor alpha. (701 aa)
TTC6TPR_REGION domain-containing protein. (1890 aa)
PAQR7Membrane progestin receptor alpha; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. (350 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (624 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform 1. (247 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
ARID1AAT-rich interaction domain 1A. (2289 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform 3. (1323 aa)
LATS2Serine/threonine-protein kinase LATS2 isoform X1. (1041 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (764 aa)
ESRRGEstrogen-related receptor gamma isoform 1. (458 aa)
PAQR8Membrane progestin receptor beta; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity); Belongs to the ADIPOR family. (387 aa)
HNF4GHepatocyte nuclear factor 4-gamma isoform 1. (462 aa)
ESRRBEstrogen related receptor beta. (458 aa)
SLC27A1Solute carrier family 27 (Fatty acid transporter), member 1. (646 aa)
NR5A1Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidy [...] (461 aa)
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (810 aa)
RENRenin preproprotein; Belongs to the peptidase A1 family. (407 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
UCN2Urocortin 2. (112 aa)
LATS1Large tumor suppressor kinase 1. (1146 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (771 aa)
A0A287AAC1_PIGUncharacterized protein. (85 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
ABHD2Abhydrolase domain containing 2. (453 aa)
OSTNMusclin. (132 aa)
A0A287A514_PIGNR LBD domain-containing protein. (88 aa)
TRIP4Thyroid hormone receptor interactor 4. (649 aa)
APPL1Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1. (708 aa)
KDM3ALysine demethylase 3A. (1323 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
RXFP1Relaxin family peptide receptor 1. (785 aa)
SSTR5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (305 aa)
YAP1Yes associated protein 1. (432 aa)
RARGRetinoic acid receptor gamma. (554 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (588 aa)
RBFOX2RNA binding fox-1 homolog 2. (578 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
SRCTyrosine-protein kinase. (559 aa)
NR3C2Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). (984 aa)
CSNK2BCasein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa)
CALCOCO1Calcium-binding and coiled-coil domain-containing protein 1 isoform X1. (715 aa)
PHB2Prohibitin. (299 aa)
PADI2Peptidyl arginine deiminase 2. (689 aa)
RXFP2Relaxin family peptide receptor 2. (737 aa)
NR1D2Uncharacterized protein. (609 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2759 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
POU4F2POU domain protein. (408 aa)
PHBProhibitin. (272 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
SSTR2Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...] (360 aa)
OR51E2Olfactory receptor. (320 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1. (1028 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
SAFBScaffold attachment factor B. (985 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (470 aa)
PHEROCUncharacterized protein. (93 aa)
ESRRASteroid hormone receptor ERR1 isoform X1. (506 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa)
GHSRGrowth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (241 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
TMF1TATA element modulatory factor 1. (1096 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1065 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
CST11Cystatin 11. (137 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (526 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
AGRPAgouti-related protein; Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. (134 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
DAXXDeath domain associated protein. (751 aa)
RXRBRetinoid X receptor beta. (536 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
ADIPOR2Adiponectin receptor protein 2 isoform X1. (386 aa)
PPARAUncharacterized protein. (469 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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