STRINGSTRING
PINK1 PINK1 MID2 MID2 WDR45 WDR45 FYCO1 FYCO1 PIP4K2A PIP4K2A WAC WAC BAG3 BAG3 SIRT1 SIRT1 HSPB8 HSPB8 SPTLC1 SPTLC1 HTT HTT ATG101 ATG101 LOC100517524 LOC100517524 ORMDL3 ORMDL3 PAFAH1B2 PAFAH1B2 SNX7 SNX7 SPTLC2 SPTLC2 A0A287AQI0_PIG A0A287AQI0_PIG TBK1 TBK1 LOC102159510 LOC102159510 ADRB2 ADRB2 A0A287B1R4_PIG A0A287B1R4_PIG HIF1A HIF1A C9orf72 C9orf72 ULK1 ULK1 RAB3GAP2 RAB3GAP2 SMCR8 SMCR8 TSC2 TSC2 ZC3H12A ZC3H12A TP53INP1 TP53INP1 PRKAA2 PRKAA2 TPCN1 TPCN1 NOD2 NOD2 MAPK3 MAPK3 TRIM38 TRIM38 ATF6 ATF6 PRKN PRKN TRIM13 TRIM13 ROCK1 ROCK1 MTDH MTDH SESN2 SESN2 SESN1 SESN1 SCOC SCOC LOC100512544 LOC100512544 KAT5 KAT5 HMOX1 HMOX1 FLCN FLCN A0A5G2QRP7_PIG A0A5G2QRP7_PIG WIPI1 WIPI1 MEFV MEFV PLEKHF1 PLEKHF1 TMEM59 TMEM59 PIP4K2C PIP4K2C CDK16 CDK16 DHRSX DHRSX A0A5G2RKP7_PIG A0A5G2RKP7_PIG PIP4K2B PIP4K2B SUPT5H SUPT5H SH3BP4 SH3BP4 SNX4 SNX4 DEPDC5 DEPDC5 LOC100736850 LOC100736850 TRIM8 TRIM8 ATG16L1 ATG16L1 RALB RALB SESN3 SESN3 A0A287A155_PIG A0A287A155_PIG IFNG IFNG TRIML2 TRIML2 TRIML1 TRIML1 LOC110259163 LOC110259163 SNX18 SNX18 FBXO7 FBXO7 LRRK2 LRRK2 DCN DCN TFEB TFEB PRKD1 PRKD1 GSK3A GSK3A VPS13D VPS13D ATG13 ATG13 PLK3 PLK3 FOXO3 FOXO3 RNF152 RNF152 SNX30 SNX30 CCNY CCNY TRIM32 TRIM32 LRSAM1 LRSAM1 ENDOG ENDOG GNAI3 GNAI3 SH3GLB1 SH3GLB1 NPRL3 NPRL3 WDR24 WDR24 FOXO1 FOXO1 KDR KDR TRIM6 TRIM6 RIPK2 RIPK2 TRIM27 TRIM27 TP53INP2 TP53INP2 UFL1 UFL1 DAPK1 DAPK1 I3LND9_PIG I3LND9_PIG OPTN OPTN BTNL9 BTNL9 PRKAA1 PRKAA1 LOC100738479 LOC100738479 RB1CC1 RB1CC1 BNIP3 BNIP3 ATG2A ATG2A CALCOCO2 CALCOCO2 BECN1 BECN1 TRIM65 TRIM65 LARP1 LARP1 PLK2 PLK2 RUFY4 RUFY4 RAB3GAP1 RAB3GAP1 TRIM21 TRIM21 TRIM68 TRIM68 TRIM22 TRIM22 STING1 STING1 IL4 IL4 STK11 STK11 AMBRA1 AMBRA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PINK1PTEN induced kinase 1. (588 aa)
MID2Midline 2. (734 aa)
WDR45WD repeat domain 45. (360 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1444 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
BAG3BCL2 associated athanogene 3. (609 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (210 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
HTTHuntingtin. (3138 aa)
ATG101Autophagy-related protein 101 isoform X1. (218 aa)
LOC100517524B30.2/SPRY domain-containing protein. (303 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (173 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
SNX7Sorting nexin 7. (482 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
A0A287AQI0_PIGB30.2/SPRY domain-containing protein. (305 aa)
TBK1TANK binding kinase TBK1. (729 aa)
LOC102159510Dehydrogenase/reductase SDR family member on chromosome X. (335 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa)
A0A287B1R4_PIGUncharacterized protein. (34 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
C9orf72C9orf72-SMCR8 complex subunit. (489 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1176 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1453 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
TSC2TSC complex subunit 2. (1836 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
TPCN1Two pore calcium channel protein 1 isoform X1. (817 aa)
NOD2Uncharacterized protein. (1013 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
TRIM38E3 ubiquitin-protein ligase TRIM38 isoform X1. (465 aa)
ATF6Activating transcription factor 6. (680 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa)
TRIM13E3 ubiquitin-protein ligase TRIM13 isoform 2. (407 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
MTDHMetadherin. (613 aa)
SESN2Sestrin 2. (471 aa)
SESN1Sestrin 1. (582 aa)
SCOCShort coiled-coil protein. (158 aa)
LOC100512544B30.2/SPRY domain-containing protein. (342 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (611 aa)
A0A5G2QRP7_PIGUncharacterized protein. (104 aa)
WIPI1Uncharacterized protein. (477 aa)
MEFVPyrin domain-containing protein. (102 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (294 aa)
TMEM59Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. (343 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (529 aa)
CDK16Cyclin dependent kinase 16. (620 aa)
DHRSXUncharacterized protein. (338 aa)
A0A5G2RKP7_PIGB30.2/SPRY domain-containing protein. (243 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
SUPT5HTranscription elongation factor SPT5. (1085 aa)
SH3BP4SH3 domain binding protein 4. (1016 aa)
SNX4Sorting nexin 4. (511 aa)
DEPDC5DEP domain-containing protein. (1593 aa)
LOC100736850B30.2/SPRY domain-containing protein. (242 aa)
TRIM8E3 ubiquitin-protein ligase TRIM8 isoform 1. (551 aa)
ATG16L1Autophagy-related protein 16-1 isoform X1. (623 aa)
RALBRAS like proto-oncogene B. (206 aa)
SESN3Sestrin-3 isoform 1. (492 aa)
A0A287A155_PIGUncharacterized protein. (58 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TRIML2Tripartite motif family like 2. (432 aa)
TRIML1Tripartite motif family like 1. (474 aa)
LOC110259163B30.2/SPRY domain-containing protein. (174 aa)
SNX18Sorting nexin 18. (807 aa)
FBXO7F-box protein 7. (606 aa)
LRRK2Uncharacterized protein. (2501 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
TFEBTranscription factor EB. (451 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
GSK3AProtein kinase domain-containing protein. (566 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4389 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
FOXO3Forkhead box protein O3 isoform X1. (672 aa)
RNF152E3 ubiquitin-protein ligase RNF152 isoform X1. (203 aa)
SNX30Sorting nexin family member 30. (449 aa)
CCNYCyclin Y; Belongs to the cyclin family. (416 aa)
TRIM32Tripartite motif containing 32. (652 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (737 aa)
ENDOGEndonuclease. (299 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (611 aa)
WDR24GATOR complex protein WDR24. (790 aa)
FOXO1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
TRIM6Tripartite motif containing 6. (487 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
TRIM27Tripartite motif containing 27. (513 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (209 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
DAPK1Death associated protein kinase 1. (1442 aa)
I3LND9_PIGUncharacterized protein. (1222 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (589 aa)
BTNL9Butyrophilin like 9. (517 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
LOC100738479Uncharacterized protein. (403 aa)
RB1CC1RB1 inducible coiled-coil 1. (1608 aa)
BNIP3BCL2 interacting protein 3. (202 aa)
ATG2AAutophagy related 2A. (1929 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (445 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
TRIM65Tripartite motif containing 65. (522 aa)
LARP1La ribonucleoprotein domain family member 1. (1101 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
RUFY4RUN and FYVE domain containing 4. (571 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (758 aa)
TRIM21Tripartite motif containing 21. (474 aa)
TRIM68Tripartite motif containing 68. (484 aa)
TRIM22Tripartite motif containing 22. (491 aa)
STING1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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