STRINGSTRING
PPARA PPARA ACADM ACADM PPP1R3B PPP1R3B FLCN FLCN PPP1R3F PPP1R3F PLEK PLEK ZNF692 ZNF692 PDK4 PDK4 PDK1 PDK1 KHK KHK BCKDK BCKDK DGKQ DGKQ SCARB2 SCARB2 GNMT GNMT PRKN PRKN IRS1 IRS1 PDK2 PDK2 PTPN2 PTPN2 MLYCD MLYCD LEP LEP P2RY6 P2RY6 NLN NLN PGP PGP IRS2 IRS2 A0A287B5K4_PIG A0A287B5K4_PIG CBFA2T3 CBFA2T3 AKT1 AKT1 TP53 TP53 INMT INMT FBP1 FBP1 GCK GCK FAM3C FAM3C DUSP12 DUSP12 ADIPOQ ADIPOQ AKT2 AKT2 C1QTNF1 C1QTNF1 SIK1 SIK1 INS INS LOC100626661 LOC100626661 PDK3 PDK3 SLC45A3 SLC45A3 BAD BAD NCOA2 NCOA2 A0A287ABS1_PIG A0A287ABS1_PIG DDIT4 DDIT4 NKX1-1 NKX1-1 A0A287A946_PIG A0A287A946_PIG ENPP1 ENPP1 EPM2AIP1 EPM2AIP1 SIRT7 SIRT7 DYRK2 DYRK2 PASK PASK CRY1 CRY1 SLC4A1 SLC4A1 FOXO1 FOXO1 OGT OGT PMAIP1 PMAIP1 C1QTNF6 C1QTNF6 GPER1 GPER1 KAT2B KAT2B ZMPSTE24 ZMPSTE24 PHLDA2 PHLDA2 INPP5K INPP5K RANBP2 RANBP2 TFF3 TFF3 LEPR LEPR TIGAR TIGAR EP300 EP300 GCKR GCKR F1SDC8_PIG F1SDC8_PIG GIT1 GIT1 COX11 COX11 IGFBP4 IGFBP4 KAT2A KAT2A STAT3 STAT3 FOXK2 FOXK2 C1QTNF3 C1QTNF3 PPP1R3A PPP1R3A SLC35B4 SLC35B4 ERFE ERFE GCG GCG AVPR1B AVPR1B NNMT NNMT INSR INSR SIRT6 SIRT6 MIDN MIDN PTH PTH DDB1 DDB1 MST1 MST1 PPP1R3C PPP1R3C SIRT1 SIRT1 PTK2B PTK2B RUBCNL RUBCNL PRKCE PRKCE LHCGR LHCGR USP7 USP7 LCMT1 LCMT1 PPP1R3D PPP1R3D RORA RORA C1QTNF12 C1QTNF12 SERPINA12 SERPINA12 PPP1R3E PPP1R3E GPLD1 GPLD1 PPP1R3G PPP1R3G IGF1 IGF1 GNB3 GNB3 FOXK1 FOXK1 HDAC4 HDAC4 ACTN3 ACTN3 GCGR GCGR LOC100625764 LOC100625764 WDR5 WDR5 ACACB ACACB A0A5G2RAG6_PIG A0A5G2RAG6_PIG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARAUncharacterized protein. (469 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (611 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (790 aa)
PLEKPleckstrin. (408 aa)
ZNF692Zinc finger protein 692. (516 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PDK1Protein-serine/threonine kinase. (454 aa)
KHKKetohexokinase. (339 aa)
BCKDKProtein-serine/threonine kinase. (453 aa)
DGKQDiacylglycerol kinase. (987 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (480 aa)
GNMTGlycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity). (334 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PDK2Protein-serine/threonine kinase. (437 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (447 aa)
MLYCDMalonyl-CoA decarboxylase. (499 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
P2RY6Pyrimidinergic receptor P2Y6. (515 aa)
NLNNeurolysin, mitochondrial; Binds angiotensins and its analogs; Belongs to the peptidase M3 family. (745 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
A0A287B5K4_PIGProtein kinase domain-containing protein. (62 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (588 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
INMTIndolethylamine N-methyltransferase isoform 1. (262 aa)
FBP1Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa)
GCKGlucokinase. (659 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
DUSP12Dual specificity protein phosphatase 12. (353 aa)
ADIPOQC1q domain-containing protein. (332 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
C1QTNF1C1q and TNF related 1. (273 aa)
SIK1Serine/threonine-protein kinase SIK1. (787 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
LOC100626661Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (313 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
SLC45A3Solute carrier family 45 member 3. (602 aa)
BADBCL2 associated agonist of cell death. (209 aa)
NCOA2Nuclear receptor coactivator. (1463 aa)
A0A287ABS1_PIGUncharacterized protein. (178 aa)
DDIT4Uncharacterized protein. (231 aa)
NKX1-1NK1 homeobox 1. (403 aa)
A0A287A946_PIGLeucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (321 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
EPM2AIP1EPM2A interacting protein 1. (608 aa)
SIRT7Sirtuin 7. (447 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa)
PASKPAS domain containing serine/threonine kinase. (1320 aa)
CRY1Cryptochrome circadian regulator 1. (588 aa)
SLC4A1Anion exchange protein. (924 aa)
FOXO1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross- talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating [...] (1074 aa)
PMAIP1Uncharacterized protein. (121 aa)
C1QTNF6C1q domain-containing protein. (285 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (831 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PHLDA2Pleckstrin homology-like domain family A member 2. (131 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (480 aa)
RANBP2RAN binding protein 2. (3233 aa)
TFF3Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). (109 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1165 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
EP300E1A binding protein p300. (2420 aa)
GCKRGlucokinase regulator. (641 aa)
F1SDC8_PIGUncharacterized protein. (1369 aa)
GIT1GIT ArfGAP 1. (761 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (271 aa)
IGFBP4Insulin-like growth factor-binding protein 4; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (259 aa)
KAT2ALysine acetyltransferase 2A. (857 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
FOXK2Forkhead box protein K2. (656 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform b. (319 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1096 aa)
SLC35B4Solute carrier family 35 member B4. (322 aa)
ERFEErythroferrone. (331 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
NNMTNicotinamide N-methyltransferase; Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. (264 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (327 aa)
MIDNMidnolin isoform X3. (503 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
DDB1Damage specific DNA binding protein 1. (1139 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
RUBCNLRubicon like autophagy enhancer. (664 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (333 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
RORARAR related orphan receptor A. (530 aa)
C1QTNF12C1q and TNF related 12. (308 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (906 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (353 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1. (340 aa)
FOXK1Forkhead box K1. (762 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (931 aa)
GCGRG_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (602 aa)
LOC100625764Uncharacterized protein. (207 aa)
WDR5WD repeat domain 5. (389 aa)
ACACBBiotin carboxylation domain-containing protein. (229 aa)
A0A5G2RAG6_PIGUncharacterized protein. (876 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.