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BNIP3 BNIP3 TSPO TSPO IGF1 IGF1 TMEM14A TMEM14A PINK1 PINK1 ACAA2 ACAA2 ADCK5 ADCK5 AVP AVP SLC35F6 SLC35F6 SLC25A31 SLC25A31 PPIF PPIF HUWE1 HUWE1 SLC25A5 SLC25A5 C11orf65 C11orf65 HGF HGF VAT1 VAT1 TIGAR TIGAR MUL1 MUL1 OMA1 OMA1 SLC25A4 SLC25A4 BAK1 BAK1 RNF41 RNF41 ADCK1 ADCK1 BOK BOK LMNA LMNA SLC25A6 SLC25A6 GHITM GHITM PARL PARL NOL3 NOL3 TP53 TP53 PSMD10 PSMD10 PRKN PRKN OPA1 OPA1 MPV17L MPV17L FLCN FLCN A0A5G2QRP7_PIG A0A5G2QRP7_PIG PRELID1 PRELID1 FXN FXN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BNIP3BCL2 interacting protein 3. (202 aa)
TSPOTranslocator protein; Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (By similarity); Belongs to the TspO/BZRP family. (169 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
TMEM14ATransmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. (99 aa)
PINK1PTEN induced kinase 1. (588 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
ADCK5AarF domain containing kinase 5. (591 aa)
AVPVasopressin-neurophysin 2-copeptin. (217 aa)
SLC35F6Solute carrier family 35 member F6; May play a role as a nucleotide-sugar transporter. (371 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (237 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4415 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
C11orf65Chromosome 11 open reading frame 65. (313 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
VAT1Synaptic vesicle membrane protein VAT-1 homolog. (400 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (305 aa)
OMA1Metalloendopeptidase OMA1, mitochondrial. (520 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
BAK1Uncharacterized protein. (266 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa)
ADCK1AarF domain containing kinase 1. (545 aa)
BOKBCL2 family apoptosis regulator BOK. (288 aa)
LMNAPrelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. A [...] (704 aa)
SLC25A6ADP/ATP translocase 3, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). (355 aa)
GHITMGrowth hormone-inducible transmembrane protein isoform X1; Belongs to the BI1 family. (345 aa)
PARLRhomboid domain-containing protein. (502 aa)
NOL3Nucleolar protein 3. (237 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1020 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (186 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (611 aa)
A0A5G2QRP7_PIGUncharacterized protein. (104 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial isoform 1. (219 aa)
FXNFrataxin. (264 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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