| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CALCR | PTH | ENSSSCP00000057815 | ENSSSCP00000014236 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | 0.706 |
| ESR1 | FGF2 | ENSSSCP00000030835 | ENSSSCP00000055271 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.459 |
| ESR1 | HRAS | ENSSSCP00000030835 | ENSSSCP00000051149 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | HRas proto-oncogene, GTPase. | 0.414 |
| ESR1 | PHB | ENSSSCP00000030835 | ENSSSCP00000018597 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Prohibitin. | 0.484 |
| ESR1 | PHB2 | ENSSSCP00000030835 | ENSSSCP00000026414 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Prohibitin. | 0.765 |
| ESR1 | PTH | ENSSSCP00000030835 | ENSSSCP00000014236 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | 0.452 |
| FGF2 | ESR1 | ENSSSCP00000055271 | ENSSSCP00000030835 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.459 |
| FGF2 | FGFR1 | ENSSSCP00000055271 | ENSSSCP00000030160 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.998 |
| FGF2 | FLT1 | ENSSSCP00000055271 | ENSSSCP00000062931 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.647 |
| FGF2 | HRAS | ENSSSCP00000055271 | ENSSSCP00000051149 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | HRas proto-oncogene, GTPase. | 0.602 |
| FGF2 | PDGFRA | ENSSSCP00000055271 | ENSSSCP00000048936 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.842 |
| FGF2 | PDGFRB | ENSSSCP00000055271 | ENSSSCP00000015373 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.636 |
| FGF2 | PTH | ENSSSCP00000055271 | ENSSSCP00000014236 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | 0.428 |
| FGFR1 | FGF2 | ENSSSCP00000030160 | ENSSSCP00000055271 | Fibroblast growth factor receptor. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.998 |
| FGFR1 | HRAS | ENSSSCP00000030160 | ENSSSCP00000051149 | Fibroblast growth factor receptor. | HRas proto-oncogene, GTPase. | 0.938 |
| FGFR1 | PDGFRA | ENSSSCP00000030160 | ENSSSCP00000048936 | Fibroblast growth factor receptor. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.504 |
| FGFR1 | PDGFRB | ENSSSCP00000030160 | ENSSSCP00000015373 | Fibroblast growth factor receptor. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.400 |
| FGFR1 | PTH | ENSSSCP00000030160 | ENSSSCP00000014236 | Fibroblast growth factor receptor. | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | 0.410 |
| FLT1 | FGF2 | ENSSSCP00000062931 | ENSSSCP00000055271 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.647 |
| HRAS | ESR1 | ENSSSCP00000051149 | ENSSSCP00000030835 | HRas proto-oncogene, GTPase. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.414 |