STRINGSTRING
TGFB1 TGFB1 CTNNB1 CTNNB1 OLIG2 OLIG2 LOC110258125 LOC110258125 SOX8 SOX8 SOX10 SOX10 NR1D1 NR1D1 LDLR LDLR NTN1 NTN1 TNFRSF1B TNFRSF1B DAAM2 DAAM2 MECP2 MECP2 TMEM98 TMEM98 LOC110259156 LOC110259156 NKX6-2 NKX6-2 NKX2-2 NKX2-2 HES5 HES5 NOG NOG LOC110255300 LOC110255300 TP53 TP53 NOTCH1 NOTCH1 LRP2 LRP2 SERPINE2 SERPINE2 BIN1 BIN1 EZH2 EZH2 HES1 HES1 ZNF488 ZNF488 RNF112 RNF112 LOC110258579 LOC110258579 SKI SKI IL1B-2 IL1B-2 ASPA ASPA PTN PTN IL34 IL34 LOC110258582 LOC110258582 BMP2 BMP2 DLX1 DLX1 TREM2 TREM2 LIF LIF GPR37L1 GPR37L1 MTOR MTOR PRKCH PRKCH PLAG1 PLAG1 IL1B2 IL1B2 LOC110258578 LOC110258578 SOX11 SOX11 GSX2 GSX2 ATOH1 ATOH1 NKX6-1 NKX6-1 RB1 RB1 NF2 NF2 ZNF365 ZNF365 EGR2 EGR2 PRKCI PRKCI CLCF1 CLCF1 F2 F2 VEGFC VEGFC DLX2 DLX2 SHH SHH GFAP GFAP NF1 NF1 HDAC1 HDAC1 KRAS KRAS IL6 IL6 NR2E1 NR2E1 UFL1 UFL1 IL6ST IL6ST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CTNNB1Catenin beta 1. (808 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
LOC110258125Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
SOX8SRY-box transcription factor 8. (460 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa)
TNFRSF1BTNF receptor superfamily member 1B. (461 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1075 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (489 aa)
TMEM98Transmembrane protein 98. (226 aa)
LOC110259156Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
NKX6-2Homeobox protein Nkx-6.2. (277 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LOC110255300Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
LRP2Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] (4626 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
BIN1Bridging integrator 1. (588 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
HES1Uncharacterized protein. (280 aa)
ZNF488Zinc finger protein 488. (323 aa)
RNF112Ring finger protein 112. (628 aa)
LOC110258579Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
SKISKI proto-oncogene. (728 aa)
IL1B-2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa)
ASPAAspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). (380 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
IL34Interleukin 34. (243 aa)
LOC110258582Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
DLX1Homeobox protein DLX-1 isoform 1. (255 aa)
TREM2Ig-like domain-containing protein. (248 aa)
LIFLeukemia inhibitory factor isoform X1. (202 aa)
GPR37L1G protein-coupled receptor 37 like 1. (459 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PRKCHProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
PLAG1PLAG1 zinc finger. (499 aa)
IL1B2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
LOC110258578Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
SOX11Transcription factor SOX. (447 aa)
GSX2GS homeobox 2. (304 aa)
ATOH1Atonal bHLH transcription factor 1. (353 aa)
NKX6-1NK6 homeobox 1. (370 aa)
RB1RB transcriptional corepressor 1. (938 aa)
NF2Neurofibromin 2. (586 aa)
ZNF365Zinc finger protein 365. (407 aa)
EGR2E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
CLCF1Uncharacterized protein. (484 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
DLX2Distal-less homeobox 2. (328 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (468 aa)
NF1Neurofibromin 1. (2847 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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