STRINGSTRING
GSC GSC CDH2 CDH2 CITED2 CITED2 SMAD4 SMAD4 SEMA6D SEMA6D SIX1 SIX1 EXT1 EXT1 JAG1 JAG1 EDNRA EDNRA EDNRB EDNRB RET RET CYP26C1 CYP26C1 NOLC1 NOLC1 SEMA3F SEMA3F SEMA3G SEMA3G KBTBD8 KBTBD8 MEF2C MEF2C SEMA3E SEMA3E ERBB4 ERBB4 HTR2B HTR2B GBX2 GBX2 SHH SHH SMO SMO ISL1 ISL1 ANXA6 ANXA6 SOX9 SOX9 OTUD5 OTUD5 WNT10A WNT10A FAM172A FAM172A CORO1C CORO1C SEMA3C SEMA3C SEMA7A SEMA7A SEMA3A SEMA3A SFRP1 SFRP1 SEMA4D SEMA4D SEMA6C SEMA6C SOX8 SOX8 RDH10 RDH10 SOX10 SOX10 SNAI2 SNAI2 SEMA3B SEMA3B BMPR1A BMPR1A LRP6 LRP6 EDN1 EDN1 GDNF GDNF FRZB FRZB SEMA6B SEMA6B PDCD6 PDCD6 SEMA4B SEMA4B SEMA4A SEMA4A HES1 HES1 ALX1 ALX1 SEMA4C SEMA4C NRP2 NRP2 SEMA5B SEMA5B HIF1A HIF1A SEMA6A SEMA6A NRTN NRTN SEMA4G SEMA4G KLHL12 KLHL12 ACVR1 ACVR1 EFNB1 EFNB1 HAND2 HAND2 MAPK3 MAPK3 PHOX2B PHOX2B SEMA4F SEMA4F SEMA5A SEMA5A TCOF1 TCOF1 PHACTR4 PHACTR4 NRP1 NRP1 PEF1 PEF1 SEMA3D SEMA3D RADIL RADIL MAPK1 MAPK1 ALDH1A2 ALDH1A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSCGoosecoid homeobox. (256 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
SIX1Six homeobox 1. (284 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (696 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (777 aa)
SEMA3GSemaphorin-3G; Belongs to the semaphorin family. (771 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8 isoform X1. (601 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
SEMA3ESemaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (481 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
ANXA6Annexin. (672 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
OTUD5OTU deubiquitinase 5. (571 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (511 aa)
SEMA3CSemaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (615 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (800 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
SEMA6CSemaphorin-6C isoform X1; Belongs to the semaphorin family. (966 aa)
SOX8SRY-box transcription factor 8. (460 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (747 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
GDNFGlial cell line-derived neurotrophic factor isoform 1. (211 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
SEMA6BSemaphorin-6B; Belongs to the semaphorin family. (901 aa)
PDCD6Programmed cell death 6. (292 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (835 aa)
SEMA4ASemaphorin-4A isoform X2; Belongs to the semaphorin family. (791 aa)
HES1Uncharacterized protein. (280 aa)
ALX1ALX homeobox 1. (326 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (896 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (920 aa)
SEMA5BSemaphorin 5B. (1126 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
SEMA6ASemaphorin-6A isoform 1; Belongs to the semaphorin family. (1047 aa)
NRTNNeurturin. (197 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (838 aa)
KLHL12BTB domain-containing protein. (916 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (729 aa)
EFNB1Ephrin-B1; Belongs to the ephrin family. (346 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (771 aa)
SEMA5ASemaphorin 5A. (1072 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1399 aa)
PHACTR4Phosphatase and actin regulator. (716 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
PEF1Penta-EF-hand domain containing 1. (334 aa)
SEMA3DSemaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa)
RADILRap associating with DIL domain. (1192 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (527 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.