STRINGSTRING
HCLS1 HCLS1 IGF1 IGF1 RGL2 RGL2 PPARD PPARD SERPINA12 SERPINA12 FGR FGR ROR1 ROR1 RASGRP1 RASGRP1 IGF1R IGF1R TEK TEK DAB2IP DAB2IP NTRK1 NTRK1 HAX1 HAX1 PPP1R16B PPP1R16B PDGFA PDGFA NCF1 NCF1 ROR2 ROR2 OSM OSM PIK3IP1 PIK3IP1 SIRT1 SIRT1 PLXNB1 PLXNB1 F2 F2 CAT CAT INSR INSR F2RL1 F2RL1 PDGFD PDGFD SEMA3E SEMA3E HGF HGF RELN RELN ERBB4 ERBB4 WNT16 WNT16 SOX9 SOX9 FSHR FSHR PRR5 PRR5 PDGFC PDGFC GPER1 GPER1 EGF EGF NOP53 NOP53 JAK2 JAK2 KDR KDR SEMA4D SEMA4D AGT AGT UNC5B UNC5B CBL CBL F2R F2R TGFB2 TGFB2 PTPN6 PTPN6 TREM2 TREM2 NTRK2 NTRK2 STAMBP STAMBP UBE3A UBE3A MYOC MYOC PDGFB PDGFB FBXL2 FBXL2 INS INS CRNN CRNN PRR5L PRR5L SERPINE2 SERPINE2 CEP55 CEP55 HCST HCST FGF2 FGF2 NEDD4 NEDD4 LEP LEP NKX3-1 NKX3-1 DIPK2A DIPK2A MYDGF MYDGF MAZ MAZ FLT1 FLT1 PIK3AP1 PIK3AP1 CSF3 CSF3 SLC9A3R1 SLC9A3R1 EGFR EGFR CD28 CD28 NTRK3 NTRK3 SELP SELP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCLS1Hematopoietic cell-specific Lyn substrate 1. (525 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
RGL2Uncharacterized protein. (802 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
FGRTyrosine-protein kinase. (537 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TEKTEK receptor tyrosine kinase. (1147 aa)
DAB2IPDAB2 interacting protein. (1196 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family. (284 aa)
PPP1R16BProtein phosphatase 1 regulatory inhibitor subunit 16B isoform X1. (568 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa)
NCF1Uncharacterized protein. (378 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
OSMOncostatin M. (234 aa)
PIK3IP1Phosphoinositide-3-kinase interacting protein 1. (296 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
PLXNB1Plexin B1. (2133 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (550 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
F2RL1Proteinase-activated receptor 2 preproprotein. (397 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (387 aa)
SEMA3ESemaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
RELNReelin. (3458 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
PRR5Proline rich 5. (386 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (470 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
AGTAngiotensinogen; Belongs to the serpin family. (482 aa)
UNC5BUnc-5 netrin receptor B. (934 aa)
CBLCbl proto-oncogene. (914 aa)
F2RG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
TREM2Ig-like domain-containing protein. (248 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
STAMBPSTAM-binding protein isoform 1. (494 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
MYOCMyocilin. (489 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
FBXL2F-box and leucine rich repeat protein 2. (476 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
CRNNCornulin. (659 aa)
PRR5LProline rich 5 like. (473 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
CEP55Centrosomal protein 55. (480 aa)
HCSTHematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] (281 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform 3. (1323 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform 1. (247 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
MYDGFMyeloid derived growth factor. (247 aa)
MAZMYC associated zinc finger protein. (494 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (905 aa)
CSF3Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. (204 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
CD28IGv domain-containing protein. (222 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa)
SELPUncharacterized protein. (671 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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