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| | PHKG1 | Phosphorylase kinase gamma 1; Belongs to the protein kinase superfamily. (388 aa) |
| | OGDH | Oxoglutarate dehydrogenase. (1035 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa) |
| | NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (357 aa) |
| | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (499 aa) |
| | COQ10B | Coenzyme Q10B. (244 aa) |
| | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (177 aa) |
| | PCDH12 | Protocadherin 12. (1200 aa) |
| | UQCRQ | Ubiquinol-cytochrome c reductase complex III subunit VII. (82 aa) |
| | LOC100524239 | Cytochrome b-c1 complex subunit 10. (56 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (550 aa) |
| | F1RKR0_PIG | Uncharacterized protein. (272 aa) |
| | COX8A | Cytochrome c oxidase subunit 8A, mitochondrial. (69 aa) |
| | NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa) |
| | SLC25A22 | Mitochondrial glutamate carrier 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (322 aa) |
| | PHKA1 | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1227 aa) |
| | ATP5PO | ATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (213 aa) |
| | PPP1R3C | Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa) |
| | LOC100512926 | Uncharacterized protein. (79 aa) |
| | KL | Klotho. (1011 aa) |
| | PGM2 | Phosphoglucomutase 2. (624 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (920 aa) |
| | SUCLG1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (393 aa) |
| | COX5B | Cytochrome c oxidase subunit 5B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (129 aa) |
| | PHKG2 | Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa) |
| | ATP5MF | ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (185 aa) |
| | PPP1R3D | Protein phosphatase 1 regulatory subunit. (299 aa) |
| | GBA | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa) |
| | NDUFS2 | NADH dehydrogenase ubiquinone iron-sulfur protein 2, mitochondrial isoform 1; Belongs to the complex I 49 kDa subunit family. (473 aa) |
| | MTFR1 | Mitochondrial fission regulator 1 isoform 1. (339 aa) |
| | NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa) |
| | NDUFA8 | CHCH domain-containing protein. (249 aa) |
| | NDUFAF1 | NADH:ubiquinone oxidoreductase complex assembly factor 1. (338 aa) |
| | COX7A2 | Uncharacterized protein. (115 aa) |
| | MTFR2 | Mitochondrial fission regulator 2. (352 aa) |
| | LOC100524873 | Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa) |
| | MTFR1L | Mitochondrial fission regulator 1 like. (292 aa) |
| | PINK1 | PTEN induced kinase 1. (588 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | ETFB | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. (255 aa) |
| | GYS1 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (744 aa) |
| | GSK3A | Protein kinase domain-containing protein. (566 aa) |
| | LOC100157935 | Uncharacterized protein. (70 aa) |
| | CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa) |
| | IREB2 | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. (963 aa) |
| | ADGRF5 | Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1340 aa) |
| | ACO2 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. (780 aa) |
| | TEFM | Transcription elongation factor, mitochondrial. (359 aa) |
| | C17orf80 | Chromosome 17 open reading frame 80. (568 aa) |
| | GAA | Glucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (937 aa) |
| | NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (123 aa) |
| | F1SMF9_PIG | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (171 aa) |
| | COX10 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. (443 aa) |
| | ND1 | NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (318 aa) |
| | ND2 | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa) |
| | COX1 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa) |
| | COX2 | Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (229 aa) |
| | COX3 | Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa) |
| | ND3 | NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (115 aa) |
| | ND4L | NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (98 aa) |
| | ND4 | NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (459 aa) |
| | ND5 | NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (606 aa) |
| | ND6 | NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (175 aa) |
| | CYTB | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa) |
| | I3L7G3_PIG | Uncharacterized protein. (118 aa) |
| | COX5A | Cytochrome c oxidase subunit 5A, mitochondrial. (152 aa) |
| | AFG1L | AFG1 like ATPase. (480 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | UQCRFS1 | Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1. (295 aa) |
| | IDH1 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (463 aa) |
| | ATP5ME | ATP synthase subunit e, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (231 aa) |
| | LEPR | Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1165 aa) |
| | B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1. (341 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1608 aa) |
| | COQ10A | Coenzyme Q10A. (243 aa) |
| | LOC100519295 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (664 aa) |
| | UQCR10 | Ubiquinol-cytochrome c reductase complex. (64 aa) |
| | ATP5F1B | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (570 aa) |
| | PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. (396 aa) |
| | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa) |
| | IL6ST | Interleukin 6 signal transducer. (938 aa) |
| | ATP5F1E | Uncharacterized protein. (136 aa) |
| | NDUFB9 | NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (221 aa) |
| | UGP2 | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family. (517 aa) |
| | GPD1 | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (404 aa) |
| | A0A286ZIT7_PIG | Uncharacterized protein. (122 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa) |
| | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa) |
| | B3GNT8 | Hexosyltransferase. (397 aa) |
| | MT3 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa) |
| | NDUFS3 | NADH dehydrogenase ubiquinone iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (264 aa) |
| | A0A286ZR98_PIG | Uncharacterized protein. (79 aa) |
| | IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. (345 aa) |
| | ETFA | Electron transfer flavoprotein subunit alpha. (369 aa) |
| | STOML2 | Stomatin like 2. (356 aa) |
| | STK40 | Serine/threonine-protein kinase 40 isoform 2. (435 aa) |
| | GYG1 | Glycogenin 1. (333 aa) |
| | A0A286ZVG2_PIG | Uncharacterized protein. (98 aa) |
| | A0A286ZVX2_PIG | Uncharacterized protein. (88 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) |
| | SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (457 aa) |
| | OGDHL | Oxoglutarate dehydrogenase like. (978 aa) |
| | IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. (452 aa) |
| | MYBBP1A | MYB binding protein 1a. (1594 aa) |
| | A0A287A3V8_PIG | Uncharacterized protein. (132 aa) |
| | COX4I2 | Cytochrome c oxidase subunit 4I2. (171 aa) |
| | LYRM7 | LYR motif containing 7; Belongs to the complex I LYR family. (108 aa) |
| | MRAP2 | Melanocortin 2 receptor accessory protein 2. (211 aa) |
| | EPM2AIP1 | EPM2A interacting protein 1. (608 aa) |
| | COX6B | Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa) |
| | C1orf198 | Chromosome 1 open reading frame 198. (348 aa) |
| | NDUFAB1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa) |
| | COX6A2 | Cytochrome c oxidase subunit 6A, mitochondrial. (97 aa) |
| | PUM2 | Pumilio RNA binding family member 2. (1072 aa) |
| | PHKB | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1090 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (481 aa) |
| | ATP5F1C | ATP synthase subunit gamma. (297 aa) |
| | PYGL | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (854 aa) |
| | DHTKD1 | Putative 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial. (864 aa) |
| | NDUFS4 | NADH:ubiquinone oxidoreductase subunit S4. (175 aa) |
| | COX6B2 | Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa) |
| | A0A287ANH8_PIG | Uncharacterized protein. (466 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa) |
| | COX7A1 | Cytochrome c oxidase subunit 7A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] (80 aa) |
| | FH | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa) |
| | SUCLA2 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa) |
| | COQ9 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (422 aa) |
| | PM20D1 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1. (489 aa) |
| | COX7C | Cytochrome c oxidase subunit 7C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (63 aa) |
| | NDUFV3 | Uncharacterized protein. (456 aa) |
| | A0A287AX33_PIG | Uncharacterized protein. (56 aa) |
| | FBXW8 | F-box and WD repeat domain containing 8. (596 aa) |
| | CYC1 | Cytochrome c1, heme protein, mitochondrial. (326 aa) |
| | ATP5PD | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (170 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa) |
| | PANK2 | Pantothenate kinase 2. (451 aa) |
| | AGL | Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1541 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | ATP5PF | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] (116 aa) |
| | GYS2 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (699 aa) |
| | PHKA2 | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1237 aa) |
| | PYGM | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1369 aa) |
| | SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (172 aa) |
| | PLEC | Plectin. (5422 aa) |
| | AIFM2 | Apoptosis inducing factor mitochondria associated 2. (415 aa) |
| | NDUFV2 | NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial. (249 aa) |
| | COX6A1 | Cytochrome c oxidase subunit 6A, mitochondrial. (109 aa) |
| | UQCRC1 | Ubiquinol-cytochrome c reductase core protein 1. (534 aa) |
| | CS | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. (464 aa) |
| | COX7B | Cytochrome c oxidase subunit 7B, mitochondrial. (80 aa) |
| | NDUFS8 | NADH dehydrogenase ubiquinone iron-sulfur protein 8, mitochondrial. (239 aa) |
| | UQCC3 | Ubiquinol-cytochrome c reductase complex assembly factor 3. (90 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | MDH1B | Malate dehydrogenase 1B. (523 aa) |
| | A0A287BMJ3_PIG | Uncharacterized protein. (196 aa) |
| | A0A287BND8_PIG | Uncharacterized protein. (84 aa) |
| | ETFDH | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. (615 aa) |
| | ATP5F1A | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (737 aa) |
| | PRLH | Prolactin releasing hormone. (87 aa) |
| | ACO1 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa) |
| | SLC37A4 | Solute carrier family 37 member 4. (451 aa) |
| | COX7A2L | Cytochrome c oxidase subunit 7A2 like. (140 aa) |
| | ETFRF1 | Electron transfer flavoprotein regulatory factor 1 isoform X1; Belongs to the complex I LYR family. (90 aa) |
| | SLC25A13 | Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (687 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa) |
| | SCO2 | SCO cytochrome c oxidase assembly protein 2. (264 aa) |
| | IDH3B | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. (602 aa) |
| | IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. (388 aa) |
| | MDH1 | Malate dehydrogenase, cytoplasmic. (352 aa) |
| | IMMP2L | Mitochondrial inner membrane protease subunit. (176 aa) |
| | DLST | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex. The 2- oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl [...] (446 aa) |
| | PDHB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa) |
| | LOC100519366 | Uncharacterized protein. (105 aa) |
| | A0A5G2QN85_PIG | Uncharacterized protein. (71 aa) |
| | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial. (203 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (937 aa) |
| | LOC100519130 | M20_dimer domain-containing protein. (554 aa) |
| | A0A5G2QZ38_PIG | COX6C domain-containing protein. (96 aa) |
| | PPP1R3B | Protein phosphatase 1 regulatory subunit. (339 aa) |
| | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa) |
| | C2orf69 | Chromosome 2 open reading frame 69. (512 aa) |
| | GBE1 | 1,4-alpha-glucan branching enzyme 1. (702 aa) |
| | FXN | Frataxin. (264 aa) |
| | DNAJC15 | DnaJ heat shock protein family (Hsp40) member C15. (164 aa) |
| | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (122 aa) |
| | PYGB | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa) |
| | SLC25A12 | Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (694 aa) |
| | MRPS36 | Mitochondrial ribosomal protein S36. (149 aa) |
| | MDH2 | Malate dehydrogenase, mitochondrial. (395 aa) |
| | SIRT3 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (351 aa) |
| | SDHB | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (328 aa) |
| | GYG2 | Glycogenin 2. (488 aa) |
| | CHCHD5 | Coiled-coil-helix-coiled-coil-helix domain containing 5. (159 aa) |
| | NDUFS1 | NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (749 aa) |
| | NDUFS7 | Uncharacterized protein. (303 aa) |
| | SDHC | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the cytochrome b560 family. (176 aa) |
| | SLC25A25 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (533 aa) |
| | STBD1 | CBM20 domain-containing protein. (508 aa) |
| | ATP5F1D | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (179 aa) |
| | NDUFA5 | NADH:ubiquinone oxidoreductase subunit A5. (117 aa) |
| | NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (188 aa) |
