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| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | PTK7 | Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa) |
| | WDR61 | WD repeat-containing protein 61 isoform a. (305 aa) |
| | CCDC88C | Coiled-coil domain containing 88C. (1906 aa) |
| | GSC | Goosecoid homeobox. (256 aa) |
| | CCNE1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa) |
| | ETV2 | ETS variant 2. (242 aa) |
| | GSK3A | Protein kinase domain-containing protein. (566 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (416 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | WLS | Wnt ligand secretion mediator. (545 aa) |
| | ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa) |
| | FOXO3 | Forkhead box protein O3 isoform X1. (672 aa) |
| | MBD2 | Methyl-CpG binding domain protein 2. (407 aa) |
| | PYGO1 | Pygopus family PHD finger 1. (419 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (808 aa) |
| | RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1093 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (244 aa) |
| | FZD6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | VANGL2 | Vang-like protein. (521 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (223 aa) |
| | RSPO4 | R-spondin 4. (235 aa) |
| | BARX1 | Homeobox protein BarH-like 1. (254 aa) |
| | VAX2 | Ventral anterior homeobox 2. (288 aa) |
| | STRN | Striatin isoform X1. (809 aa) |
| | CPE | Carboxypeptidase E. (475 aa) |
| | SFRP2 | Uncharacterized protein. (294 aa) |
| | EDNRA | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (970 aa) |
| | EDNRB | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (464 aa) |
| | SFRP5 | Uncharacterized protein. (315 aa) |
| | LDB1 | LID domain-containing protein. (411 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (669 aa) |
| | ZRANB1 | Zinc finger RANBP2-type containing 1. (734 aa) |
| | RYK | Receptor like tyrosine kinase. (566 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1139 aa) |
| | LGR4 | Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa) |
| | CSNK1G3 | Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (454 aa) |
| | CCDC90B | Coiled-coil domain-containing protein 90B, mitochondrial isoform 1. (254 aa) |
| | F1SM96_PIG | DIX domain-containing protein. (471 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1. (349 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) |
| | JUP | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa) |
| | DLX3 | Distal-less homeobox 3. (287 aa) |
| | TAX1BP3 | Tax1 binding protein 3. (191 aa) |
| | CTDNEP1 | CTD nuclear envelope phosphatase 1. (244 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (794 aa) |
| | IFT80 | Intraflagellar transport 80. (767 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | CDH3 | Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (826 aa) |
| | NXN | Nucleoredoxin. (439 aa) |
| | NDP | Norrin cystine knot growth factor NDP. (133 aa) |
| | MESD | Mesoderm development LRP chaperone. (232 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | ARL6 | ADP ribosylation factor like GTPase 6; Belongs to the small GTPase superfamily. Arf family. (193 aa) |
| | HESX1 | HESX homeobox 1. (185 aa) |
| | DVL3 | Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa) |
| | TMEM198 | Transmembrane protein 198. (360 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | CALCOCO1 | Calcium-binding and coiled-coil domain-containing protein 1 isoform X1. (715 aa) |
| | LZTS2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (667 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | TCF7 | Transcription factor 7. (484 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | CSNK2B | Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa) |
| | SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (309 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (389 aa) |
| | GPC3 | Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | RSPO3 | Uncharacterized protein. (280 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (674 aa) |
| | HMGXB4 | HMG-box containing 4. (691 aa) |
| | YAP1 | Yes associated protein 1. (432 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | C12orf43 | Chromosome 12 open reading frame 43. (274 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (774 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | RAB5A | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | TMEM170B | Transmembrane protein 170B. (132 aa) |
| | BMP2 | Bone morphogenetic protein 2 preproprotein. (395 aa) |
| | BCL9 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). (1435 aa) |
| | APC2 | Uncharacterized protein. (2292 aa) |
| | LOC100523244 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (482 aa) |
| | APC | APC_basic domain-containing protein. (2713 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (773 aa) |
| | SFRP4 | Secreted frizzled-related protein 4. (346 aa) |
| | TLE5 | TLE family member 5, transcriptional modulator. (197 aa) |
| | FRAT1 | Uncharacterized protein. (279 aa) |
| | PORCN | Protein-serine O-palmitoleoyltransferase porcupine isoform D; Belongs to the membrane-bound acyltransferase family. (461 aa) |
| | NDRG2 | Protein NDRG2 isoform a. (371 aa) |
| | HBP1 | HMG-box transcription factor 1. (564 aa) |
| | MYOC | Myocilin. (489 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (955 aa) |
| | CTNNBIP1 | Beta-catenin-interacting protein 1. (81 aa) |
| | CELSR2 | Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2917 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa) |
| | LRP4 | LDL receptor related protein 4. (1918 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | FRZB | Secreted frizzled-related protein 3. (325 aa) |
| | CSNK2A2 | Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa) |
| | MED12 | Mediator complex subunit 12. (2187 aa) |
| | DDIT3 | DNA-damage-inducible transcript 3. (167 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | SOST | Sclerostin. (212 aa) |
| | KREMEN2 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | RSPO1 | R-spondin 1. (262 aa) |
| | STK3 | Serine/threonine kinase 3. (542 aa) |
| | GID8 | GID complex subunit 8 homolog. (296 aa) |
| | LOC110259300 | Uncharacterized protein; Belongs to the cyclin family. (347 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | MITF | Microphthalmia-associated transcription factor isoform 1. (520 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | CSNK1G1 | Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (466 aa) |
| | TGFB1I1 | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (519 aa) |
| | AMOTL1 | Angiomotin-like protein 1 isoform X1. (990 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (228 aa) |
| | SCYL2 | SCY1 like pseudokinase 2. (934 aa) |
| | GRHL3 | Grainyhead like transcription factor 3. (607 aa) |
| | LATS2 | Serine/threonine-protein kinase LATS2 isoform X1. (1041 aa) |
| | FZD8 | Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa) |
| | AXIN2 | Axin-2. (843 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa) |
| | KLHL12 | BTB domain-containing protein. (916 aa) |
| | RNF146 | Ring finger protein 146. (369 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa) |
| | BCL9L | BCL9 like. (1526 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | CELSR1 | Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3320 aa) |
| | CSNK1G2 | Casein kinase I isoform gamma-2; Belongs to the protein kinase superfamily. (414 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | TCF7L1 | HMG box domain-containing protein. (412 aa) |
| | FGF9 | Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa) |
| | CSNK1A1 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (359 aa) |
| | AMOTL2 | Angiomotin like 2. (732 aa) |
| | NKD2 | Uncharacterized protein. (611 aa) |
| | PKD1 | Polycystin 1, transient receptor potential channel interacting. (4383 aa) |
| | RECK | Reversion-inducing cysteine-rich protein with Kazal motifs isoform 1. (971 aa) |
| | DIXDC1 | Calponin-homology (CH) domain-containing protein. (218 aa) |
| | FERMT2 | Fermitin family member 2. (776 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (560 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa) |
| | LRRFIP1 | LRR binding FLII interacting protein 1. (856 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (229 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (750 aa) |
| | WWOX | WW domain containing oxidoreductase. (414 aa) |
| | PLPP3 | acidPPc domain-containing protein. (369 aa) |
| | STK4 | Serine/threonine kinase 4. (502 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | RSPO2 | Uncharacterized protein. (242 aa) |
| | CSNK1D | Casein kinase 1 delta. (459 aa) |
