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| | LIX1 | Limb and CNS expressed 1. (281 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | LIX1L | Limb and CNS expressed 1 like. (337 aa) |
| | EPG5 | Ectopic P-granules autophagy protein 5 homolog. (2577 aa) |
| | CHMP2A | Charged multivesicular body protein 2A. (222 aa) |
| | CHMP1A | Uncharacterized protein. (196 aa) |
| | UFL1 | E3 UFM1-protein ligase 1. (792 aa) |
| | STING1 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa) |
| | ATG16L2 | Autophagy related 16 like 2. (647 aa) |
| | PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa) |
| | PJVK | Pejvakin. (351 aa) |
| | ATG10 | Autophagy related 10. (330 aa) |
| | SPG11 | SPG11 vesicle trafficking associated, spatacsin. (2467 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (237 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1608 aa) |
| | VAMP8 | V-SNARE coiled-coil homology domain-containing protein. (143 aa) |
| | STX12 | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (369 aa) |
| | ATG9B | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (923 aa) |
| | RAB33B | RAB33B, member RAS oncogene family. (229 aa) |
| | UBQLN2 | Ubiquilin 2. (576 aa) |
| | CTSD | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (408 aa) |
| | ATG4D | Cysteine protease ATG4D, mitochondrial; [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C- terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. (514 aa) |
| | MCOLN1 | Mucolipin 1. (663 aa) |
| | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1042 aa) |
| | C5orf51 | Chromosome 5 open reading frame 51. (249 aa) |
| | ATG16L1 | Autophagy-related protein 16-1 isoform X1. (623 aa) |
| | RUFY4 | RUN and FYVE domain containing 4. (571 aa) |
| | RETREG2 | Reticulophagy regulator family member 2. (542 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (201 aa) |
| | VMP1 | Vacuole membrane protein 1. (417 aa) |
| | TRAPPC8 | Trafficking protein particle complex 8. (1441 aa) |
| | MAP1LC3C | Microtubule associated protein 1 light chain 3 gamma. (147 aa) |
| | ILRUN | N_BRCA1_IG domain-containing protein. (217 aa) |
| | CHMP5 | Uncharacterized protein. (219 aa) |
| | BECN2 | Beclin 2. (444 aa) |
| | VTI1A | Vesicle transport through interaction with t-SNAREs 1A. (216 aa) |
| | SNAP29 | Synaptosome associated protein 29. (258 aa) |
| | RUBCNL | Rubicon like autophagy enhancer. (664 aa) |
| | WDFY3 | WD repeat and FYVE domain containing 3. (3526 aa) |
| | MFSD8 | Major facilitator superfamily domain containing 8. (517 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (409 aa) |
| | MAP1LC3A | Microtubule-associated protein 1 light chain 3 alpha. (121 aa) |
| | GAA | Glucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (937 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (209 aa) |
| | OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross- talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating [...] (1074 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa) |
| | TMEM41B | Transmembrane protein 41B isoform X1. (291 aa) |
| | RETREG1 | Reticulophagy regulator 1. (565 aa) |
| | VPS33A | Vacuolar protein sorting 33A homolog; Belongs to the STXBP/unc-18/SEC1 family. (596 aa) |
| | UVRAG | UV radiation resistance associated. (748 aa) |
| | VPS39 | VPS39 subunit of HOPS complex. (898 aa) |
| | CHMP4A | Charged multivesicular body protein 4A. (229 aa) |
| | RAB7A | RAB7A, member RAS oncogene family. (252 aa) |
| | STX17 | Syntaxin-17 isoform X1; Belongs to the syntaxin family. (302 aa) |
| | PACS2 | Phosphofurin acidic cluster sorting protein 2 isoform X1. (889 aa) |
| | MTM1 | Myotubularin isoform X3. (603 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa) |
| | PLEKHM1 | Pleckstrin homology domain-containing family M member 1 isoform X1. (1048 aa) |
| | BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa) |
| | CALCOCO2 | Calcium binding and coiled-coil domain 2. (445 aa) |
| | GABARAP | Uncharacterized protein. (98 aa) |
| | ATG2A | Autophagy related 2A. (1929 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | RAB23 | RAB23, member RAS oncogene family. (206 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] (878 aa) |
| | ATG9A | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (871 aa) |
| | TEX264 | Testis expressed 264, ER-phagy receptor. (284 aa) |
| | PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa) |
| | CHMP2B | Charged multivesicular body protein 2B. (213 aa) |
| | WDR45 | WD repeat domain 45. (360 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa) |
| | ATG13 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1176 aa) |
| | TECPR1 | Tectonin beta-propeller repeat containing 1. (1070 aa) |
| | LAMP2 | Lysosome-associated membrane glycoprotein 2 isoform A. (411 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | LGALS8 | Galectin. (368 aa) |
| | ATG2B | Autophagy related 2B. (2077 aa) |
| | NSFL1C | NSFL1 cofactor. (370 aa) |
| | KIAA1324 | KIAA1324. (1013 aa) |
| | GBA | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa) |
| | UFC1 | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa) |
| | SNX30 | Sorting nexin family member 30. (449 aa) |
| | ATG14 | Autophagy related 14. (510 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa) |
| | PINK1 | PTEN induced kinase 1. (588 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | ATG3 | Autophagy-related protein 3. (320 aa) |
| | MAP1LC3B | Microtubule-associated protein 1 light chain 3 beta. (125 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa) |
| | ZFYVE1 | Zinc finger FYVE-type containing 1. (790 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2540 aa) |
| | VTI1B | t-SNARE coiled-coil homology domain-containing protein. (232 aa) |
| | GABARAPL1 | Uncharacterized protein. (148 aa) |
| | AMBRA1 | Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa) |
| | CHMP7 | Charged multivesicular body protein 7. (505 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1131 aa) |
| | ATG101 | Autophagy-related protein 101 isoform X1. (218 aa) |
| | ATG7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (710 aa) |
| | YOD1 | YOD1 deubiquitinase. (306 aa) |
| | SNX7 | Sorting nexin 7. (482 aa) |
| | NBR1 | Next to BRCA1 gene 1 protein isoform X1. (960 aa) |
| | A0A287AMX4_PIG | Uncharacterized protein. (121 aa) |
| | CHMP3 | Uncharacterized protein. (251 aa) |
| | STBD1 | CBM20 domain-containing protein. (508 aa) |
| | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa) |
| | ZFYVE21 | Zinc finger FYVE-type containing 21. (289 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa) |
| | PLAA | Phospholipase A2 activating protein. (1044 aa) |
| | SNX14 | Sorting nexin 14. (944 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (859 aa) |
| | ULK3 | Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (842 aa) |
| | WIPI1 | Uncharacterized protein. (477 aa) |
| | HMOX1 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa) |
| | RAB19 | RAB19, member RAS oncogene family. (246 aa) |
| | WIPI2 | WD repeat domain, phosphoinositide interacting 2. (559 aa) |
| | GABARAPL2 | Uncharacterized protein. (187 aa) |
| | VPS41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (953 aa) |
| | AP4M1 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (471 aa) |
| | UBA5 | Ubiquitin like modifier activating enzyme 5. (447 aa) |
| | UBXN2A | UBX domain protein 2A. (308 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa) |
| | TMEM74 | Transmembrane protein 74. (303 aa) |
| | ATG4B | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (402 aa) |
| | RAB1A | Ras-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secreti [...] (217 aa) |
| | RETREG3 | Reticulophagy regulator family member 3. (466 aa) |
| | DDRGK1 | DDRGK domain-containing protein 1. (312 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | MFN2 | Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | SQSTM1 | Sequestosome 1. (451 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1302 aa) |
| | TP53INP1 | Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa) |
| | WDR81 | WD repeat-containing protein 81 isoform X1. (1945 aa) |
| | UBXN2B | UBX domain protein 2B. (369 aa) |
| | UBXN6 | UBX domain protein 6. (546 aa) |
| | UBQLN1 | Ubiquilin 1. (582 aa) |
| | CLN3 | Battenin. (414 aa) |
| | EI24 | EI24 autophagy associated transmembrane protein. (262 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | HDAC10 | Histone deacetylase 10. (671 aa) |
