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PIK3R4 PIK3R4 RNF41 RNF41 A0A287A155_PIG A0A287A155_PIG SESN3 SESN3 RALB RALB TBC1D25 TBC1D25 ATP6V0A1 ATP6V0A1 SNX4 SNX4 ATP13A2 ATP13A2 SUPT5H SUPT5H PIP4K2B PIP4K2B PAFAH1B2 PAFAH1B2 SNX7 SNX7 SPTLC2 SPTLC2 TMEM39B TMEM39B TBK1 TBK1 ADRB2 ADRB2 UBQLN1 UBQLN1 CLN3 CLN3 NRBP2 NRBP2 TP53 TP53 HIF1A HIF1A C9orf72 C9orf72 SMG1 SMG1 ULK1 ULK1 TECPR1 TECPR1 RAB3GAP2 RAB3GAP2 FEZ1 FEZ1 SMCR8 SMCR8 ATG12 ATG12 SEC22B SEC22B TSC2 TSC2 PRKAA2 PRKAA2 UBQLN4 UBQLN4 NOD2 NOD2 MAPK3 MAPK3 HDAC6 HDAC6 VPS13C VPS13C TRIM13 TRIM13 SESN2 SESN2 SESN1 SESN1 SCOC SCOC HMOX1 HMOX1 A0A5G2QRP7_PIG A0A5G2QRP7_PIG CLEC16A CLEC16A WIPI1 WIPI1 QSOX1 QSOX1 SCFD1 SCFD1 ATG5 ATG5 LRRK2 LRRK2 EHMT2 EHMT2 MTOR MTOR VPS13D VPS13D PINK1 PINK1 PIK3C3 PIK3C3 ATG14 ATG14 SNX30 SNX30 LRSAM1 LRSAM1 GNAI3 GNAI3 SH3GLB1 SH3GLB1 WDR24 WDR24 HTT HTT SPTLC1 SPTLC1 LZTS1 LZTS1 HSPB8 HSPB8 SIRT1 SIRT1 BAG3 BAG3 WAC WAC PIP4K2A PIP4K2A FYCO1 FYCO1 RUBCN RUBCN TMEM39A TMEM39A WDR45 WDR45 AMBRA1 AMBRA1 IL4 IL4 STING1 STING1 RAB3GAP1 RAB3GAP1 RUFY4 RUFY4 LARP1 LARP1 BECN1 BECN1 CALCOCO2 CALCOCO2 PHF23 PHF23 ATG2A ATG2A FEZ2 FEZ2 TIGAR TIGAR BNIP3 BNIP3 MTMR8 MTMR8 OPTN OPTN PIP4K2C PIP4K2C POLDIP2 POLDIP2 I3LND9_PIG I3LND9_PIG RIPK2 RIPK2 KDR KDR CHMP4A CHMP4A SNX18 SNX18 MTM1 MTM1 UBQLN2 UBQLN2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1302 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa)
A0A287A155_PIGUncharacterized protein. (58 aa)
SESN3Sestrin-3 isoform 1. (492 aa)
RALBRAS like proto-oncogene B. (206 aa)
TBC1D25TBC1 domain family member 25 isoform c. (690 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
SNX4Sorting nexin 4. (511 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1131 aa)
SUPT5HTranscription elongation factor SPT5. (1085 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
SNX7Sorting nexin 7. (482 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
TMEM39BTransmembrane protein 39B. (492 aa)
TBK1TANK binding kinase TBK1. (729 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa)
UBQLN1Ubiquilin 1. (582 aa)
CLN3Battenin. (414 aa)
NRBP2Nuclear receptor binding protein 2. (599 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
C9orf72C9orf72-SMCR8 complex subunit. (489 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3646 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1176 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1070 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1453 aa)
FEZ1Fasciculation and elongation protein zeta 1. (420 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (233 aa)
TSC2TSC complex subunit 2. (1836 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
UBQLN4Ubiquilin-4 isoform 1. (601 aa)
NOD2Uncharacterized protein. (1013 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
HDAC6Histone deacetylase 6. (1159 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3757 aa)
TRIM13E3 ubiquitin-protein ligase TRIM13 isoform 2. (407 aa)
SESN2Sestrin 2. (471 aa)
SESN1Sestrin 1. (582 aa)
SCOCShort coiled-coil protein. (158 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa)
A0A5G2QRP7_PIGUncharacterized protein. (104 aa)
CLEC16AC-type lectin domain containing 16A. (1082 aa)
WIPI1Uncharacterized protein. (477 aa)
QSOX1Sulfhydryl oxidase. (742 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (664 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa)
LRRK2Uncharacterized protein. (2501 aa)
EHMT2Uncharacterized protein. (1233 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4389 aa)
PINK1PTEN induced kinase 1. (588 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
ATG14Autophagy related 14. (510 aa)
SNX30Sorting nexin family member 30. (449 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (737 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
WDR24GATOR complex protein WDR24. (790 aa)
HTTHuntingtin. (3138 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
LZTS1Leucine zipper putative tumor suppressor 1 isoform X1. (596 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (210 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
BAG3BCL2 associated athanogene 3. (609 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1444 aa)
RUBCNKIAA0226 protein transcript variant 2. (971 aa)
TMEM39ATransmembrane protein 39A isoform X3. (488 aa)
WDR45WD repeat domain 45. (360 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
STING1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (758 aa)
RUFY4RUN and FYVE domain containing 4. (571 aa)
LARP1La ribonucleoprotein domain family member 1. (1101 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (445 aa)
PHF23PHD finger protein 23. (403 aa)
ATG2AAutophagy related 2A. (1929 aa)
FEZ2Fasciculation and elongation protein zeta-2 isoform 2. (376 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
BNIP3BCL2 interacting protein 3. (202 aa)
MTMR8Myotubularin-related protein 8. (692 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (589 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (529 aa)
POLDIP2Polymerase delta-interacting protein 2 isoform 1. (368 aa)
I3LND9_PIGUncharacterized protein. (1222 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
CHMP4ACharged multivesicular body protein 4A. (229 aa)
SNX18Sorting nexin 18. (807 aa)
MTM1Myotubularin isoform X3. (603 aa)
UBQLN2Ubiquilin 2. (576 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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