STRINGSTRING
CMKLR1 CMKLR1 LGR5 LGR5 TSHR TSHR DCAF8 DCAF8 LGR6 LGR6 GPR1 GPR1 RXFP2 RXFP2 FSHR FSHR INSR INSR AMHR2 AMHR2 MCHR1 MCHR1 ADIPOR2 ADIPOR2 IGF1R IGF1R INSRR INSRR GNRHR2 GNRHR2 LHCGR LHCGR F1SPW0_PIG F1SPW0_PIG LGR4 LGR4 UBA6 UBA6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CMKLR1Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). (363 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (764 aa)
DCAF8DDB1 and CUL4 associated factor 8. (639 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (967 aa)
GPR1G-protein coupled receptor 1 isoform X2; Belongs to the G-protein coupled receptor 1 family. (355 aa)
RXFP2Relaxin family peptide receptor 2. (737 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (583 aa)
MCHR1Melanin-concentrating hormone receptor 1; Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. (353 aa)
ADIPOR2Adiponectin receptor protein 2 isoform X1. (386 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
INSRRTyrosine-protein kinase receptor. (1315 aa)
GNRHR2Gonadotropin-releasing hormone receptor isoform 1. (293 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa)
F1SPW0_PIGWD_REPEATS_REGION domain-containing protein. (604 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
UBA6Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. (1396 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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