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| | SPINK1 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). (79 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | HCK | Tyrosine-protein kinase. (527 aa) |
| | YES1 | Tyrosine-protein kinase. (553 aa) |
| | DSTYK | Dual serine/threonine and tyrosine protein kinase. (1049 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | EPHA3 | Ephrin type-A receptor 3 isoform X1. (984 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1208 aa) |
| | TNK2 | Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1159 aa) |
| | MST1R | Macrophage stimulating 1 receptor. (1398 aa) |
| | EPHB1 | Ephrin type-B receptor 1. (984 aa) |
| | AATK | Apoptosis associated tyrosine kinase. (1410 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1342 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa) |
| | WEE2 | Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. (565 aa) |
| | EPHA1 | Ephrin type-A receptor 1. (982 aa) |
| | EPHA4 | EPH receptor A4. (986 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1201 aa) |
| | CLK1 | CDC-like kinase 1; Belongs to the protein kinase superfamily. (484 aa) |
| | PTPN4 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa) |
| | RELN | Reelin. (3458 aa) |
| | HPX | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | HIPK3 | Homeodomain-interacting protein kinase 3 isoform X1. (1216 aa) |
| | EPHB3 | Ephrin type-B receptor 3. (999 aa) |
| | ABI1 | Abl interactor 1 isoform b. (481 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | ROR2 | Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa) |
| | EPHA5 | EPH receptor A5. (1041 aa) |
| | TEC | Tyrosine-protein kinase. (632 aa) |
| | TXK | Tyrosine-protein kinase. (551 aa) |
| | PKDCC | Protein kinase domain containing, cytoplasmic. (493 aa) |
| | EPHB4 | EPH receptor B4. (935 aa) |
| | PDGFRL | Platelet-derived growth factor receptor-like protein. (375 aa) |
| | HIPK1 | Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa) |
| | INSRR | Tyrosine-protein kinase receptor. (1315 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (795 aa) |
| | DDR2 | Discoidin domain receptor tyrosine kinase 2. (866 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | TEK | TEK receptor tyrosine kinase. (1147 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | TYRO3 | TYRO3 protein tyrosine kinase. (913 aa) |
| | FRK | Tyrosine-protein kinase. (511 aa) |
| | FYN | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) |
| | TIE1 | Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa) |
| | IL12RB2 | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. (861 aa) |
| | FGR | Tyrosine-protein kinase. (537 aa) |
| | EPHB2 | EPH receptor B2. (987 aa) |
| | EPHA8 | EPH receptor A8. (930 aa) |
| | EPHA2 | Ephrin type-A receptor 2 isoform 1. (975 aa) |
| | CSK | Tyrosine-protein kinase. (474 aa) |
| | PTPN9 | Protein tyrosine phosphatase non-receptor type 9. (593 aa) |
| | PEAK1 | Pseudopodium enriched atypical kinase 1. (1748 aa) |
| | FES | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | TTBK1 | Tau tubulin kinase 1. (1305 aa) |
| | STYK1 | Serine/threonine/tyrosine kinase 1. (424 aa) |
| | RPS6KA5 | Non-specific serine/threonine protein kinase. (957 aa) |
| | TNK1 | Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (788 aa) |
| | CLK2 | CDC like kinase 2. (529 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | EPHA6 | EPH receptor A6. (1153 aa) |
| | HTR2A | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa) |
| | ITK | Tyrosine-protein kinase. (598 aa) |
| | FLT1 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa) |
| | CSF1R | Colony stimulating factor 1 receptor. (1053 aa) |
| | TWF1 | Twinfilin actin binding protein 1. (366 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa) |
| | SYK | 40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa) |
| | TYK2 | Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa) |
| | LIF | Leukemia inhibitory factor isoform X1. (202 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa) |
| | PTK6 | Tyrosine-protein kinase. (449 aa) |
| | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa) |
| | DYRK1B | Dual specificity tyrosine phosphorylation regulated kinase 1B. (778 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1483 aa) |
| | BLK | Tyrosine-protein kinase. (501 aa) |
| | MERTK | MER proto-oncogene, tyrosine kinase. (998 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1092 aa) |
| | PIBF1 | Progesterone immunomodulatory binding factor 1. (782 aa) |
| | A0A5G2RBJ3_PIG | Tyrosine-protein kinase receptor. (542 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | TTK | TTK protein kinase. (947 aa) |
| | CNTF | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). (619 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (924 aa) |
| | NTRK3 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa) |
| | MUSK | Muscle associated receptor tyrosine kinase. (869 aa) |
| | LRRK1 | Leucine rich repeat kinase 1. (2030 aa) |
| | AXL | Uncharacterized protein. (871 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | FGFRL1 | Fibroblast growth factor receptor like 1. (566 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (855 aa) |
| | IL21 | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Belongs to the IL-1 [...] (160 aa) |
| | DYRK1A | Dual specificity tyrosine phosphorylation regulated kinase 1A. (764 aa) |
| | LCK | Tyrosine-protein kinase. (520 aa) |
| | SRMS | Tyrosine-protein kinase. (494 aa) |
| | EFEMP1 | EGF containing fibulin extracellular matrix protein 1. (512 aa) |
| | DDR1 | Tyrosine-protein kinase receptor. (1005 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (903 aa) |
| | ZAP70 | Tyrosine-protein kinase. (615 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (820 aa) |
| | ALK | Uncharacterized protein. (1034 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (820 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (182 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa) |
| | ROS1 | Tyrosine-protein kinase receptor. (2343 aa) |
| | RSRC2 | Arginine/serine-rich coiled-coil protein 2 isoform X1. (435 aa) |
| | EPHB6 | EPH receptor B6. (1006 aa) |
| | MATK | Tyrosine-protein kinase. (485 aa) |
| | EPHA7 | Ephrin type-A receptor 7 isoform 1. (998 aa) |
| | EPHA10 | EPH receptor A10. (1013 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (655 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa) |
| | CLK3 | CDC like kinase 3; Belongs to the protein kinase superfamily. (495 aa) |
| | ABL2 | Tyrosine-protein kinase. (1096 aa) |
| | BMX | Tyrosine-protein kinase. (706 aa) |
| | FLT3 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa) |
| | HIPK4 | Homeodomain-interacting protein kinase 4. (617 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | ABL1 | Tyrosine-protein kinase. (1146 aa) |
| | CLK4 | CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa) |
| | HMCN1 | Hemicentin-1. (5636 aa) |
| | NRP2 | Neuropilin; Belongs to the neuropilin family. (920 aa) |
