STRINGSTRING
RHEB RHEB RAB35 RAB35 ARL3 ARL3 RAB4A RAB4A RAB5C RAB5C DIRAS2 DIRAS2 RAB3B RAB3B DIRAS3 DIRAS3 TMEM19 TMEM19 RAB31 RAB31 MRAS MRAS RALA RALA RAB10 RAB10 RAB22A RAB22A GNAT1 GNAT1 ARF6 ARF6 RAP2B RAP2B RAB14 RAB14 RAB9B RAB9B HRAS HRAS ARL2 ARL2 RAB8B RAB8B A0A287ARP2_PIG A0A287ARP2_PIG NRAS NRAS DIRAS1 DIRAS1 MIEF1 MIEF1 DYNC1LI1 DYNC1LI1 RASEF RASEF RAB27A RAB27A RALB RALB RRAS2 RRAS2 A0A287A0E5_PIG A0A287A0E5_PIG RAP1B RAP1B RAP2A RAP2A RASL12 RASL12 RAB27B RAB27B RAB5A RAB5A RAB7A RAB7A RRAGD RRAGD RAB9A RAB9A TRIM23 TRIM23 GEM GEM RAB29 RAB29 RAP2C RAP2C RAB28 RAB28 KRAS KRAS RAB17 RAB17 GNAI1 GNAI1 RAB8A RAB8A RAB11B RAB11B SEPTIN12 SEPTIN12 GNAI3 GNAI3 RIT1 RIT1 RAB2A RAB2A RRAS RRAS SRP54 SRP54 RERG RERG RHEBL1 RHEBL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHEBUncharacterized protein. (220 aa)
RAB35Uncharacterized protein. (233 aa)
ARL3ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] (306 aa)
RAB4ARAB4A, member RAS oncogene family. (223 aa)
RAB5CUncharacterized protein. (227 aa)
DIRAS2GTP-binding protein Di-Ras2. (199 aa)
RAB3BRAB3B, member RAS oncogene family. (249 aa)
DIRAS3GTP-binding RAS-like protein 3. (228 aa)
TMEM19Transmembrane protein 19. (492 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
MRASMuscle RAS oncogene homolog. (210 aa)
RALARas-related protein Ral-A isoform X1. (206 aa)
RAB10Uncharacterized protein. (201 aa)
RAB22AUncharacterized protein. (256 aa)
GNAT1Guanine nucleotide-binding protein G(T) subunit alpha-1 isoform X2. (350 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...] (175 aa)
RAP2BRas-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). (183 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell [...] (197 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family. (211 aa)
RAB8BRAB8B, member RAS oncogene family. (215 aa)
A0A287ARP2_PIGUncharacterized protein. (192 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
DIRAS1DIRAS family GTPase 1. (352 aa)
MIEF1Mitochondrial dynamics protein MID51 isoform X1. (463 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
RASEFEF-hand domain-containing protein. (684 aa)
RAB27ARas-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa)
RALBRAS like proto-oncogene B. (206 aa)
RRAS2Uncharacterized protein. (276 aa)
A0A287A0E5_PIGUncharacterized protein. (151 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
RAP2ARas-related protein Rap-2a. (183 aa)
RASL12RAS like family 12. (266 aa)
RAB27BRAB27B, member RAS oncogene family. (247 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
RAB7ARAB7A, member RAS oncogene family. (252 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
TRIM23E3 ubiquitin-protein ligase TRIM23 isoform alpha. (574 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
RAB29RAB29, member RAS oncogene family. (221 aa)
RAP2CRAP2C, member of RAS oncogene family. (183 aa)
RAB28RAB28, member RAS oncogene family. (252 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RAB17RAB17, member RAS oncogene family. (288 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
RAB8AUncharacterized protein. (242 aa)
RAB11BUncharacterized protein. (205 aa)
SEPTIN12Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (363 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
RIT1Ras like without CAAX 1. (219 aa)
RAB2ARAB2A, member RAS oncogene family. (226 aa)
RRASRAS related. (218 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
RERGRAS like estrogen regulated growth inhibitor. (180 aa)
RHEBL1RHEB like 1. (183 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (26%) [HD]