STRINGSTRING
PCSK6 PCSK6 ACVRL1 ACVRL1 EPHA2 EPHA2 EPHA8 EPHA8 IGF2R IGF2R THBS1 THBS1 IGF1R IGF1R IGFBPL1 IGFBPL1 SEC61B SEC61B COL5A1 COL5A1 NTRK1 NTRK1 HAX1 HAX1 IL9R IL9R IGFALS IGFALS IL1R2 IL1R2 FGFBP1 FGFBP1 IGFBP7 IGFBP7 KL KL HYAL2 HYAL2 FIBP FIBP API5 API5 INSR INSR FLT4 FLT4 FSTL4 FSTL4 PDGFRB PDGFRB COL1A2 COL1A2 ACVR1C ACVR1C GHRHR GHRHR IGFBP1 IGFBP1 F1SMH1_PIG F1SMH1_PIG IGFBP4 IGFBP4 ERBB2 ERBB2 NGFR NGFR WFIKKN2 WFIKKN2 KLB KLB ERBB3 ERBB3 IGFBP5 IGFBP5 GLG1 GLG1 FLT3 FLT3 CD109 CD109 SHC1 SHC1 TGFBR2 TGFBR2 LIFR LIFR KDR KDR ENG ENG FGFR1 FGFR1 FGFR2 FGFR2 CHRDL1 CHRDL1 FGFR4 FGFR4 IL6ST IL6ST TGFB3 TGFB3 TGFBR1 TGFBR1 ITGAV ITGAV ITGA6 ITGA6 COL3A1 COL3A1 WFIKKN1 WFIKKN1 COL2A1 COL2A1 LTBP1 LTBP1 SORT1 SORT1 RHBDF2 RHBDF2 KAZALD1 KAZALD1 IL2RA IL2RA NTRK2 NTRK2 LRRC32 LRRC32 CXCL13 CXCL13 PDGFB PDGFB TGFBR3L TGFBR3L FGFRL1 FGFRL1 FGFR3 FGFR3 GHR GHR GPC1 GPC1 PDGFRA PDGFRA VASN VASN EPHA7 EPHA7 HMCN1 HMCN1 S100A13 S100A13 FURIN FURIN NRROS NRROS ACVR1 ACVR1 LTBP3 LTBP3 IGFBP2 IGFBP2 FGFBP3 FGFBP3 RHBDF1 RHBDF1 TRIM16 TRIM16 A0A287BS73_PIG A0A287BS73_PIG A0A5G2QUL4_PIG A0A5G2QUL4_PIG NKD2 NKD2 FLT1 FLT1 HTRA1 HTRA1 IGFBP6 IGFBP6 COL6A1 COL6A1 COL1A1 COL1A1 ACVR2B ACVR2B IL1R1 IL1R1 TWSG1 TWSG1 EGFR EGFR IL6R IL6R TSKU TSKU NRP1 NRP1 ITGB4 ITGB4 LTBP4 LTBP4 TGFBR3 TGFBR3 NTRK3 NTRK3 ITGB3 ITGB3 SCN5A SCN5A LTBP2 LTBP2 ACVR1B ACVR1B CEP57 CEP57
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK6Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. (965 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
EPHA8EPH receptor A8. (930 aa)
IGF2RInsulin-like growth factor II receptor. (2488 aa)
THBS1Uncharacterized protein. (1170 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
IGFBPL1Insulin-like growth factor-binding protein-like 1. (275 aa)
SEC61BUncharacterized protein. (138 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family. (284 aa)
IL9RFibronectin type-III domain-containing protein. (290 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (606 aa)
IL1R2Interleukin 1 receptor type 2. (413 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (237 aa)
IGFBP7Uncharacterized protein. (278 aa)
KLKlotho. (1011 aa)
HYAL2Hyaluronidase. (476 aa)
FIBPAcidic fibroblast growth factor intracellular-binding protein isoform b. (357 aa)
API5Apoptosis inhibitor 5. (526 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
FSTL4Follistatin like 4. (848 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
GHRHRGrowth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. (451 aa)
IGFBP1Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity). (263 aa)
F1SMH1_PIGCep57_CLD domain-containing protein. (228 aa)
IGFBP4Insulin-like growth factor-binding protein 4; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (259 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
NGFRNerve growth factor receptor. (414 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (580 aa)
KLBKlotho beta. (1044 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
IGFBP5Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (271 aa)
GLG1Golgi glycoprotein 1. (1210 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa)
CD109CD109 antigen isoform 1 preproprotein. (1449 aa)
SHC1SHC adaptor protein 1. (583 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
LIFRLIF receptor subunit alpha. (1170 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
CHRDL1Chordin like 1. (526 aa)
FGFR4Fibroblast growth factor receptor. (903 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1708 aa)
SORT1Sortilin. (963 aa)
RHBDF2Rhomboid 5 homolog 2. (827 aa)
KAZALD1Kazal-type serine protease inhibitor domain-containing protein 1 isoform X1. (315 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (283 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LRRC32Leucine rich repeat containing 32. (688 aa)
CXCL13C-X-C motif chemokine. (111 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (285 aa)
FGFRL1Fibroblast growth factor receptor like 1. (566 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. (660 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
VASNVasorin isoform X2. (677 aa)
EPHA7Ephrin type-A receptor 7 isoform 1. (998 aa)
HMCN1Hemicentin-1. (5636 aa)
S100A13S_100 domain-containing protein; Belongs to the S-100 family. (209 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (797 aa)
NRROSNegative regulator of reactive oxygen species. (704 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (729 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
IGFBP2Insulin-like growth factor-binding protein 2; May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (316 aa)
FGFBP3Fibroblast growth factor binding protein 3. (256 aa)
RHBDF1Rhomboid 5 homolog 1. (1034 aa)
TRIM16Uncharacterized protein. (582 aa)
A0A287BS73_PIGNeurobeachin-like protein 2 isoform X1. (243 aa)
A0A5G2QUL4_PIGUncharacterized protein. (536 aa)
NKD2Uncharacterized protein. (611 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
HTRA1HtrA serine peptidase 1. (479 aa)
IGFBP6IGFBP N-terminal domain-containing protein. (312 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
IL1R1Interleukin-1 receptor type 1 isoform 1. (572 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
IL6RInterleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. (491 aa)
TSKUTsukushi, small leucine rich proteoglycan. (357 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
ITGB4Integrin beta. (1814 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
TGFBR3Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1887 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1814 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
CEP57Uncharacterized protein. (499 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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