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| | PHACTR1 | Phosphatase and actin regulator. (651 aa) |
| | SKAP1 | Src kinase-associated phosphoprotein 1. (367 aa) |
| | TCTEX1D4 | Tctex1 domain-containing protein 4. (218 aa) |
| | CTTNBP2NL | CTTNBP2 N-terminal-like protein isoform X1. (639 aa) |
| | KIFAP3 | Kinesin-associated protein 3 isoform X1. (809 aa) |
| | CLEC12A | C-type lectin domain family 12 member A. (263 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | STRN3 | Striatin 3. (797 aa) |
| | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (771 aa) |
| | ROS1 | Tyrosine-protein kinase receptor. (2343 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa) |
| | A0A287AS64_PIG | Uncharacterized protein. (72 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1095 aa) |
| | FOXO1 | Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa) |
| | IGBP1 | Uncharacterized protein. (339 aa) |
| | PPP1R10 | Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] (925 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1. (2994 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | PPP6R2 | Protein phosphatase 6 regulatory subunit 2. (1102 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | STX17 | Syntaxin-17 isoform X1; Belongs to the syntaxin family. (302 aa) |
| | FCRL3 | Fc receptor-like protein 3 isoform 1. (729 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | SMTNL1 | Calponin-homology (CH) domain-containing protein. (182 aa) |
| | C20orf27 | Chromosome 20 open reading frame 27. (198 aa) |
| | MTMR3 | Myotubularin related protein 3. (1215 aa) |
| | CLEC12B | C-type lectin domain-containing protein. (274 aa) |
| | PIK3R2 | Uncharacterized protein. (772 aa) |
| | LGALS3 | Galectin. (271 aa) |
| | MTMR9 | Myotubularin related protein 9. (576 aa) |
| | FBXL20 | F-box and leucine rich repeat protein 20. (456 aa) |
| | CSF1R | Colony stimulating factor 1 receptor. (1053 aa) |
| | ITGA1 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa) |
| | PPP1R3F | Protein phosphatase 1 regulatory subunit 3F. (790 aa) |
| | PPP1R3B | Protein phosphatase 1 regulatory subunit. (339 aa) |
| | PHACTR4 | Phosphatase and actin regulator. (716 aa) |
| | MASTL | Microtubule associated serine/threonine kinase like. (881 aa) |
| | PHACTR3 | Phosphatase and actin regulator. (627 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (527 aa) |
| | LOC100736623 | Ig-like domain-containing protein. (181 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1425 aa) |
| | PTPA | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (332 aa) |
| | MFHAS1 | Malignant fibrous histiocytoma amplified sequence 1. (1062 aa) |
| | PPP6R3 | Protein phosphatase 6 regulatory subunit 3. (888 aa) |
| | STRN4 | Striatin-4 isoform 2. (891 aa) |
| | LRRD1 | Leucine rich repeats and death domain containing 1. (848 aa) |
| | FBXO41 | F-box protein 41. (874 aa) |
| | SHOC2 | Leucine-rich repeat protein SHOC-2 isoform X1. (582 aa) |
| | GTF2F1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (545 aa) |
| | A0A287AAZ2_PIG | Uncharacterized protein. (71 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | FBXL2 | F-box and leucine rich repeat protein 2. (476 aa) |
| | LCK | Tyrosine-protein kinase. (520 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa) |
| | GNA12 | G protein subunit alpha 12. (382 aa) |
| | CD22 | CD22 molecule. (890 aa) |
| | CDKN1B | p27Kip1. (198 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1171 aa) |
| | TBK1 | TANK binding kinase TBK1. (729 aa) |
| | PTPRT | Protein tyrosine phosphatase receptor type T. (1460 aa) |
| | HMCN2 | Hemicentin 2. (5047 aa) |
| | DAB2IP | DAB2 interacting protein. (1196 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. (818 aa) |
| | PPP6R1 | Protein phosphatase 6 regulatory subunit 1. (881 aa) |
| | VRK3 | VRK serine/threonine kinase 3. (513 aa) |
| | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A. (654 aa) |
| | KCNN4 | Intermediate conductance calcium-activated potassium channel protein 4. (426 aa) |
| | AKAP5 | A-kinase anchoring protein 5. (427 aa) |
| | NEK2 | NIMA related kinase 2. (404 aa) |
| | PPP1R3E | Protein phosphatase 1 regulatory subunit 3E. (279 aa) |
| | ANKLE2 | Ankyrin repeat and LEM domain containing 2. (966 aa) |
| | PPME1 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (399 aa) |
| | SNX3 | Sorting nexin-3 isoform a. (162 aa) |
| | ENSA | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity); Belongs to the endosulfine [...] (137 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | SMTNL2 | Smoothelin like 2. (457 aa) |
| | IQGAP1 | IQ motif containing GTPase activating protein 1. (1709 aa) |
| | PPP1R11 | Protein phosphatase 1 regulatory inhibitor subunit 11. (126 aa) |
| | PPP1R3G | Protein phosphatase 1 regulatory subunit 3G. (353 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa) |
| | SKAP2 | Src kinase associated phosphoprotein 2. (423 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (155 aa) |
| | AP3B2 | AP-3 complex subunit beta. (1130 aa) |
| | MVP | Major vault protein. (900 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | RACK1 | Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (By similarity). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to [...] (317 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | STYXL1 | Serine/threonine/tyrosine-interacting-like protein 1 isoform X1. (313 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (597 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | MTMR4 | Myotubularin related protein 4. (1205 aa) |
| | PPP1R9B | Protein phosphatase 1 regulatory subunit 9B. (817 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | JUP | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | SPHK1 | Sphingosine kinase 1 isoform 2. (481 aa) |
| | BOD1 | Uncharacterized protein. (267 aa) |
| | PPP1R3A | Protein phosphatase 1 regulatory subunit 3A. (1096 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa) |
| | FAM71F2 | Family with sequence similarity 71 member F2. (299 aa) |
| | FAM71F1 | Family with sequence similarity 71 member F1. (343 aa) |
| | SH3RF2 | SH3 domain containing ring finger 2. (729 aa) |
| | PDLIM4 | PDZ and LIM domain protein 4 isoform 1. (331 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa) |
| | AMBRA1 | Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa) |
| | PPP1R3C | Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5 isoform X1. (755 aa) |
| | STRN | Striatin isoform X1. (809 aa) |
| | PPP1R3D | Protein phosphatase 1 regulatory subunit. (299 aa) |
| | PPP1R16B | Protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1. (568 aa) |
| | FCRL6 | Fc receptor-like protein 6 isoform X2. (480 aa) |
