(34 nodes) Cyclic-nucleotide-mediated signaling network (Sus scrofa)

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Your Input:
	AQP1	Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa)
	DGKQ	Diacylglycerol kinase. (987 aa)
	GLP1R	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (468 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1662 aa)
	PDE2A	Phosphodiesterase. (1010 aa)
	GHRHR	Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. (451 aa)
	HTR2B	5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (481 aa)
	ATF1	Activating transcription factor 1. (269 aa)
	GUCY1A1	Guanylate cyclase soluble subunit alpha-1 isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
	PDE7A	Phosphodiesterase. (483 aa)
	PDE7B	Phosphodiesterase. (505 aa)
	CAP1	Adenylyl cyclase-associated protein; Belongs to the CAP family. (473 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
	CAP2	Adenylyl cyclase-associated protein; Belongs to the CAP family. (486 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	KSR1	Kinase suppressor of ras 1. (928 aa)
	PDE3A	Phosphodiesterase. (1145 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (735 aa)
	PDE9A	Phosphodiesterase. (565 aa)
	AHR	Aryl hydrocarbon receptor. (849 aa)
	MRVI1	Murine retrovirus integration site 1 homolog. (938 aa)
	LOC100625149	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (676 aa)
	CGAS	Cyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second m [...] (495 aa)
	DEFB1-2	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (64 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
	HTR2C	5-hydroxytryptamine receptor 2C. (457 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
	PRKG1	cGMP-dependent protein kinase. (686 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (649 aa)
	ADGRG6	Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1247 aa)
	ADCYAP1	Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). (176 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	HTR2C	ENSSSCP00000017716	ENSSSCP00000030956	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	5-hydroxytryptamine receptor 2C.	0.406
ADCY1	PDE3A	ENSSSCP00000017716	ENSSSCP00000019727	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.833
ADCY1	PDE7A	ENSSSCP00000017716	ENSSSCP00000006629	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.706
ADCY1	PDE7B	ENSSSCP00000017716	ENSSSCP00000004501	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.706
ADCYAP1	ADORA2B	ENSSSCP00000054892	ENSSSCP00000020204	Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.438
ADCYAP1	CREB1	ENSSSCP00000054892	ENSSSCP00000035901	Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).	Cyclic AMP-responsive element-binding protein 1 isoform B.	0.463
ADCYAP1	GHRHR	ENSSSCP00000054892	ENSSSCP00000017661	Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).	Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.	0.618
ADCYAP1	GLP1R	ENSSSCP00000054892	ENSSSCP00000069601	Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.946
ADORA2B	ADCYAP1	ENSSSCP00000020204	ENSSSCP00000054892	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).	0.438
ADORA2B	GHRHR	ENSSSCP00000020204	ENSSSCP00000017661	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.	0.419
ADORA2B	GLP1R	ENSSSCP00000020204	ENSSSCP00000069601	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.405
APOE	INS	ENSSSCP00000003343	ENSSSCP00000044635	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.688
ATF1	CREB1	ENSSSCP00000017098	ENSSSCP00000035901	Activating transcription factor 1.	Cyclic AMP-responsive element-binding protein 1 isoform B.	0.664
CAP1	CAP2	ENSSSCP00000003976	ENSSSCP00000001139	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.595
CAP2	CAP1	ENSSSCP00000001139	ENSSSCP00000003976	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.595
CAP2	GUCY1B1	ENSSSCP00000001139	ENSSSCP00000047708	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.401
CAP2	LOC100625149	ENSSSCP00000001139	ENSSSCP00000023953	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.401
CREB1	ADCYAP1	ENSSSCP00000035901	ENSSSCP00000054892	Cyclic AMP-responsive element-binding protein 1 isoform B.	Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).	0.463
CREB1	ATF1	ENSSSCP00000035901	ENSSSCP00000017098	Cyclic AMP-responsive element-binding protein 1 isoform B.	Activating transcription factor 1.	0.664
CREB1	INS	ENSSSCP00000035901	ENSSSCP00000044635	Cyclic AMP-responsive element-binding protein 1 isoform B.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.594