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| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (492 aa) |
| | ARPC3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa) |
| | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1 isoform X1. (849 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | WASF3 | Wiskott-Aldrich syndrome protein family member 3 isoform X1. (498 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (970 aa) |
| | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2. (1553 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1379 aa) |
| | RAB13 | Uncharacterized protein. (203 aa) |
| | HAX1 | HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family. (284 aa) |
| | ABITRAM | Protein Simiate. (185 aa) |
| | ACTC1 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa) |
| | CDH2 | Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa) |
| | EPHA2 | Ephrin type-A receptor 2 isoform 1. (975 aa) |
| | PDPN | Uncharacterized protein. (159 aa) |
| | CARMIL3 | Capping protein regulator and myosin 1 linker 3. (1370 aa) |
| | CIB1 | Calcium and integrin-binding protein 1 isoform b. (191 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | CDC42BPB | Serine/threonine-protein kinase MRCK beta isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1712 aa) |
| | SPATA13 | Uncharacterized protein. (1159 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (840 aa) |
| | ITGB1BP1 | Integrin subunit beta 1 binding protein 1. (270 aa) |
| | LOC110255205 | SH3 domain-containing protein. (355 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (862 aa) |
| | UNC5C | Unc-5 netrin receptor C. (937 aa) |
| | KPTN | Kaptin, actin binding protein. (436 aa) |
| | PKN2 | Serine/threonine-protein kinase N2 isoform 1. (983 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | A0A286ZIE2_PIG | Uncharacterized protein. (441 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa) |
| | ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa) |
| | AMOT | Angiomotin isoform X1. (1088 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (546 aa) |
| | FAP | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa) |
| | CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa) |
| | FLOT1 | Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa) |
| | STMN2 | Stathmin; Belongs to the stathmin family. (184 aa) |
| | STX2 | Syntaxin 2; Belongs to the syntaxin family. (347 aa) |
| | GDPD2 | Glycerophosphodiester phosphodiesterase domain containing 2. (569 aa) |
| | CFL1 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). (179 aa) |
| | IQGAP2 | IQ motif containing GTPase activating protein 2. (1542 aa) |
| | SLC39A6 | Solute carrier family 39 member 6. (811 aa) |
| | PODXL | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (516 aa) |
| | FSCN3 | Fascin. (498 aa) |
| | DBNL | Drebrin like. (429 aa) |
| | PARVB | Parvin beta. (364 aa) |
| | PPP1R9B | Protein phosphatase 1 regulatory subunit 9B. (817 aa) |
| | CARMIL2 | Capping protein regulator and myosin 1 linker 2. (1406 aa) |
| | CDK5 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa) |
| | RAPGEF3 | Rap guanine nucleotide exchange factor 3 isoform a. (923 aa) |
| | SH3BP1 | Uncharacterized protein. (643 aa) |
| | CORO1C | Coronin; Belongs to the WD repeat coronin family. (511 aa) |
| | ILK | Integrin linked kinase. (479 aa) |
| | CORO6 | Coronin; Belongs to the WD repeat coronin family. (470 aa) |
| | IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (577 aa) |
| | WASF2 | Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | ARHGAP31 | Rho GTPase-activating protein 31. (1453 aa) |
| | FSCN1 | Fascin. (465 aa) |
| | ACTN1 | Uncharacterized protein. (888 aa) |
| | LOC102158424 | Uncharacterized protein; Belongs to the actin family. (466 aa) |
| | LIMK1 | LIM domain kinase 1. (681 aa) |
| | MYO10 | Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa) |
| | TSC1 | TSC complex subunit 1. (1166 aa) |
| | NF2 | Neurofibromin 2. (586 aa) |
| | ACTA2 | Actin alpha 2, smooth muscle. (386 aa) |
| | SHTN1 | Shootin 1. (631 aa) |
| | ABI1 | Abl interactor 1 isoform b. (481 aa) |
| | TWF2 | Twinfilin actin binding protein 2. (500 aa) |
| | BRK1 | BRICK1 subunit of SCAR/WAVE actin nucleating complex. (103 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain containing 1. (960 aa) |
| | CD44 | CD44 molecule (Indian blood group). (767 aa) |
| | PDLIM4 | PDZ and LIM domain protein 4 isoform 1. (331 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (835 aa) |
| | MEFV | Pyrin domain-containing protein. (102 aa) |
| | RAC2 | Rac family small GTPase 2. (217 aa) |
| | PLXND1 | Plexin D1. (1926 aa) |
| | CTTN | Cortactin. (685 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa) |
| | P4HB | Protein disulfide-isomerase. (623 aa) |
| | SNX1-2 | PX domain-containing protein. (474 aa) |
| | PHACTR4 | Phosphatase and actin regulator. (716 aa) |
| | ANTXR1 | ANTXR cell adhesion molecule 1. (564 aa) |
| | A0A5G2QM05_PIG | Uncharacterized protein. (545 aa) |
| | ABLIM3 | Actin binding LIM protein family member 3. (694 aa) |
| | PARVA | Parvin alpha. (373 aa) |
| | SNX1 | Sorting nexin-1 isoform a. (522 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | ACTR3B | Uncharacterized protein; Belongs to the actin family. (463 aa) |
| | RAC1 | Rac family small GTPase 1. (186 aa) |
| | WASL | WASP like actin nucleation promoting factor. (511 aa) |
| | NME2 | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] (404 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (585 aa) |
| | AJUBA | Ajuba LIM protein. (565 aa) |
| | DPP4 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa) |
| | A0A287BS73_PIG | Neurobeachin-like protein 2 isoform X1. (243 aa) |
| | A0A287BRC5_PIG | ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (190 aa) |
| | CDH1 | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (925 aa) |
| | PALLD | Palladin, cytoskeletal associated protein. (1350 aa) |
| | SNX2 | Sorting nexin-2 isoform 1. (525 aa) |
| | ACTA1 | Actin, alpha skeletal muscle. (465 aa) |
| | KITLG | Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (276 aa) |
| | CAPRIN1 | Cell cycle associated protein 1. (709 aa) |
| | ACTG2 | Actin gamma 2, smooth muscle. (417 aa) |
| | SYNE2 | Spectrin repeat containing nuclear envelope protein 2. (6940 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CORO1B | Coronin; Belongs to the WD repeat coronin family. (496 aa) |
| | CAPG | Capping actin protein, gelsolin like. (385 aa) |
| | CCDC88A | Coiled-coil domain containing 88A. (1873 aa) |
| | LOC100621521 | SH3 domain-containing protein. (357 aa) |
| | ARPIN | Uncharacterized protein. (260 aa) |
| | CLRN1 | Clarin 1. (232 aa) |
| | EVL | Enah/Vasp-like. (466 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (887 aa) |
| | KCNA2 | Potassium voltage-gated channel, shaker-related subfamily, member 2; Belongs to the potassium channel family. (499 aa) |
| | PDXP | Pyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. (296 aa) |
| | CIB3 | Calcium and integrin binding family member 3. (206 aa) |
| | PLCE1 | Phosphoinositide phospholipase C. (2316 aa) |
| | RAC3 | Rac family small GTPase 3. (192 aa) |
| | VASP | Vasodilator stimulated phosphoprotein. (389 aa) |
| | SPEF1 | Calponin-homology (CH) domain-containing protein. (275 aa) |
| | WASF1 | WH2 domain-containing protein. (559 aa) |
| | RHOA | Transforming protein RhoA isoform 1. (193 aa) |
| | SCYL3 | SCY1 like pseudokinase 3. (734 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa) |
| | FAM89B | Family with sequence similarity 89 member B. (192 aa) |
| | PABPC1 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa) |
| | CTNNA1 | Catenin alpha 1. (1090 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa) |
| | STX3 | Syntaxin 3; Belongs to the syntaxin family. (347 aa) |
| | VAMP7 | Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (258 aa) |
| | LOC110256054 | WH2 domain-containing protein. (558 aa) |
| | MYLK | Myosin light chain kinase, smooth muscle; Phosphorylates a specific serine in the N-terminus of a myosin light chain. Also regulates actin-myosin interaction through a non-kinase activity (By similarity). (1981 aa) |
| | MYO1G | Myosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (983 aa) |
| | ALS2 | Alsin Rho guanine nucleotide exchange factor ALS2. (1662 aa) |
| | GSN | Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Belongs to the villin/gelsolin family. (780 aa) |
| | ABI2 | Abl interactor 2. (542 aa) |
| | DGKZ | Diacylglycerol kinase. (1144 aa) |
| | APC | APC_basic domain-containing protein. (2713 aa) |
| | PTPRM | Protein tyrosine phosphatase receptor type M. (1507 aa) |
| | APC2 | Uncharacterized protein. (2292 aa) |
| | CDC42BPA | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1847 aa) |
| | AIF1 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). Has a dual influence on glucose-induced insulin secretion: inhibition at low concentration and stimulation at high concentrations. (147 aa) |
| | CARMIL1 | Capping protein regulator and myosin 1 linker 1. (1429 aa) |
| | VIL1 | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa) |
| | SORBS2 | Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Increases water and sodium absorption in the intestine [...] (1432 aa) |
| | ACTR3 | Actin related protein 3; Belongs to the actin family. (422 aa) |
| | ARPC5 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa) |
| | INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa) |
| | DPYSL3 | Dihydropyrimidinase like 3. (683 aa) |
