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F1SF13_PIG F1SF13_PIG CATIP CATIP LMOD2 LMOD2 VIL1 VIL1 DLG1 DLG1 ARPC4 ARPC4 AIF1 AIF1 ARPC2 ARPC2 MSRB1 MSRB1 LOC100513346 LOC100513346 GSN GSN SPIRE1 SPIRE1 A0A287A9Q1_PIG A0A287A9Q1_PIG GAS7 GAS7 WASHC3 WASHC3 WAS WAS FHDC1 FHDC1 ATP5F1A ATP5F1A WASL WASL DLG2 DLG2 PSTPIP1 PSTPIP1 DIAPH1 DIAPH1 CTTN CTTN HCLS1 HCLS1 SPIRE2 SPIRE2 WASHC5 WASHC5 MICALL2 MICALL2 DIAPH3 DIAPH3 MSRB2 MSRB2 TTC17 TTC17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F1SF13_PIGCobl domain-containing protein. (406 aa)
CATIPUncharacterized protein. (398 aa)
LMOD2Leiomodin 2. (550 aa)
VIL1Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (231 aa)
AIF1Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). Has a dual influence on glucose-induced insulin secretion: inhibition at low concentration and stimulation at high concentrations. (147 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (273 aa)
MSRB1Methionine-R-sulfoxide reductase B1; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to a [...] (94 aa)
LOC100513346Coronin; Belongs to the WD repeat coronin family. (962 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Belongs to the villin/gelsolin family. (780 aa)
SPIRE1Spire type actin nucleation factor 1. (802 aa)
A0A287A9Q1_PIGUncharacterized protein. (136 aa)
GAS7Growth arrest specific 7. (519 aa)
WASHC3WASH complex subunit 3. (194 aa)
WASWASP actin nucleation promoting factor. (500 aa)
FHDC1FH2 domain containing 1. (1001 aa)
ATP5F1AATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (737 aa)
WASLWASP like actin nucleation promoting factor. (511 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
PSTPIP1Proline-serine-threonine phosphatase interacting protein 1. (443 aa)
DIAPH1Diaphanous related formin 1. (817 aa)
CTTNCortactin. (685 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (525 aa)
SPIRE2Spire type actin nucleation factor 2. (763 aa)
WASHC5WASH complex subunit 5 isoform X1. (1159 aa)
MICALL2MICAL-like protein 2 isoform X1. (887 aa)
DIAPH3Diaphanous related formin 3. (1138 aa)
MSRB2Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (182 aa)
TTC17Tetratricopeptide repeat domain 17. (1141 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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