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| | BCL6 | B-cell lymphoma 6 protein isoform X1. (706 aa) |
| | PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa) |
| | ABI1 | Abl interactor 1 isoform b. (481 aa) |
| | CCL19 | C-C motif chemokine. (100 aa) |
| | PRDX3 | Thioredoxin domain-containing protein. (261 aa) |
| | NKX2-3 | NK2 homeobox 3. (367 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | ABCB10 | ATP binding cassette subfamily B member 10. (725 aa) |
| | SH2B3 | SH2B adaptor protein 3. (600 aa) |
| | DMTN | Dematin actin binding protein. (405 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (545 aa) |
| | LYAR | Ly1 antibody reactive. (386 aa) |
| | EPAS1 | Uncharacterized protein. (870 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2 alpha kinase 1. (633 aa) |
| | NCOA6 | Nuclear receptor coactivator 6. (2061 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | GBA | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | DCSTAMP | Dendrocyte expressed seven transmembrane protein. (487 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (131 aa) |
| | ARID4A | AT-rich interaction domain 4A. (1279 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | EPB42 | Erythrocyte membrane protein band 4.2. (688 aa) |
| | OSTM1 | Osteoclastogenesis associated transmembrane protein 1. (335 aa) |
| | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa) |
| | EPHA2 | Ephrin type-A receptor 2 isoform 1. (975 aa) |
| | TYROBP | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (109 aa) |
| | ETV2 | ETS variant 2. (242 aa) |
| | CEBPA | CCAAT/enhancer-binding protein alpha isoform c. (354 aa) |
| | RCOR1 | REST corepressor 1. (487 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa) |
| | CEBPE | CCAAT/enhancer-binding protein. (282 aa) |
| | SRP54 | Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | CIB1 | Calcium and integrin-binding protein 1 isoform b. (191 aa) |
| | IREB2 | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. (963 aa) |
| | ADGRF5 | Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1340 aa) |
| | SRF | Serum response factor. (512 aa) |
| | TET2 | Tet methylcytosine dioxygenase 2. (2019 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (829 aa) |
| | TSPAN2 | Tetraspanin. (335 aa) |
| | CALCR | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. (490 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (447 aa) |
| | CSF1 | Colony stimulating factor 1. (656 aa) |
| | PABPC4 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa) |
| | FARP2 | FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1163 aa) |
| | G6PD | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (649 aa) |
| | JMJD6 | Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (413 aa) |
| | KAT8 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (461 aa) |
| | LTBR | Uncharacterized protein. (432 aa) |
| | A0A5G2QBC0_PIG | Glyoxalase domain-containing protein. (113 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1164 aa) |
| | UBA5 | Ubiquitin like modifier activating enzyme 5. (447 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1169 aa) |
| | A0A5G2QHJ7_PIG | Uncharacterized protein. (148 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | CSF1R | Colony stimulating factor 1 receptor. (1053 aa) |
| | GPR183 | G-protein coupled receptor 183 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1128 aa) |
| | LOC100517166 | Uncharacterized protein. (152 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa) |
| | PDE1B | Phosphodiesterase. (535 aa) |
| | TMOD3 | Uncharacterized protein. (386 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (525 aa) |
| | IL20 | Interleukin 20. (175 aa) |
| | CBFB | Core-binding factor subunit beta. (204 aa) |
| | A0A5G2R3N8_PIG | Uncharacterized protein. (135 aa) |
| | LOC110259478 | Uncharacterized protein. (197 aa) |
| | VPS33B | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (650 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (513 aa) |
| | CD81 | Tetraspanin. (258 aa) |
| | TF-2 | Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (702 aa) |
| | TOB2 | Protein Tob2 isoform X1. (353 aa) |
| | NRROS | Negative regulator of reactive oxygen species. (704 aa) |
| | ZNF385A | Zinc finger protein 385A. (406 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa) |
| | A0A287BDP1_PIG | Uncharacterized protein. (48 aa) |
| | MAEA | Macrophage erythroblast attacher. (591 aa) |
| | KLF2 | Kruppel-like factor 2. (357 aa) |
| | CBFA2T3 | CBFA2/RUNX1 partner transcriptional co-repressor 3. (588 aa) |
| | MITF | Microphthalmia-associated transcription factor isoform 1. (520 aa) |
| | ZBTB46 | Zinc finger and BTB domain-containing protein 46. (589 aa) |
| | CCN4 | WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa) |
| | ZFPM1 | Zinc finger protein, FOG family member 1. (965 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa) |
| | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (771 aa) |
| | PLA2G10 | Phospholipase A(2). (188 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (722 aa) |
| | PKNOX1 | PBX/knotted 1 homeobox 1. (435 aa) |
| | A0A287ATT1_PIG | Uncharacterized protein. (114 aa) |
| | IRF8 | Interferon regulatory factor 8. (426 aa) |
| | LBR | Lamin-B receptor. (626 aa) |
| | TSPO2 | Translocator protein 2. (171 aa) |
| | IL17C | Interleukin 17C. (193 aa) |
| | THOC5 | THO complex subunit 5 homolog isoform X1. (694 aa) |
| | A0A287ANG8_PIG | Protein kinase domain-containing protein. (183 aa) |
| | EFNA2 | Ephrin A2; Belongs to the ephrin family. (216 aa) |
| | FOXP1 | Forkhead box P1. (692 aa) |
| | TCTA | T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa) |
| | AHSP | Alpha-hemoglobin-stabilizing protein. (92 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (164 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | LRRK1 | Leucine rich repeat kinase 1. (2030 aa) |
| | L3MBTL3 | Lethal(3)malignant brain tumor-like protein 3 isoform X2. (780 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (596 aa) |
| | IRF4 | Interferon regulatory factor 4. (451 aa) |
| | MEIS1 | Homeobox protein Meis1. (465 aa) |
| | GP9 | Glycoprotein IX platelet. (173 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (469 aa) |
| | DHRS7B | Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa) |
| | FLI1 | Fli-1 proto-oncogene, ETS transcription factor. (480 aa) |
| | TREM2 | Ig-like domain-containing protein. (248 aa) |
| | A0A286ZXY0_PIG | Uncharacterized protein. (139 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | IKZF1 | IKAROS family zinc finger 1. (575 aa) |
| | A0A286ZWW0_PIG | AIG1-type G domain-containing protein. (321 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | TRIM10 | Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis. (517 aa) |
| | ERCC2 | General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa) |
| | PRKX | Uncharacterized protein; Belongs to the protein kinase superfamily. (358 aa) |
| | MFHAS1 | Malignant fibrous histiocytoma amplified sequence 1. (1062 aa) |
| | MPIG6B | Ig-like domain-containing protein. (328 aa) |
| | WDR1 | WD repeat-containing protein 1 isoform 1. (606 aa) |
| | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (574 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | ADD1 | Adducin 1. (786 aa) |
| | BAP1 | BRCA1 associated protein 1. (759 aa) |
| | P14ARF | ANK_REP_REGION domain-containing protein. (159 aa) |
| | SMAD5 | Mothers against decapentaplegic homolog. (465 aa) |
| | CAMK4 | Calcium/calmodulin dependent protein kinase IV. (534 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | ANXA2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa) |
| | GPR68 | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | VPS33A | Vacuolar protein sorting 33A homolog; Belongs to the STXBP/unc-18/SEC1 family. (596 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | SLC4A1 | Anion exchange protein. (924 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | GPC3 | Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (182 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (629 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | PIR | Pirin; Belongs to the pirin family. (291 aa) |
| | CD109 | CD109 antigen isoform 1 preproprotein. (1449 aa) |
| | BATF2 | Basic leucine zipper transcriptional factor ATF-like 2 isoform 1. (276 aa) |
| | UFL1 | E3 UFM1-protein ligase 1. (792 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (520 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1314 aa) |
| | CASP8 | Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa) |
| | CLEC1B | C-type lectin domain family 1 member B. (226 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa) |
| | ACTN1 | Uncharacterized protein. (888 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | C15orf41 | Chromosome 15 open reading frame 41. (287 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (220 aa) |
| | JUNB | JunB proto-oncogene, AP-1 transcription factor subunit. (347 aa) |
| | KMT2E | Myeloid/lymphoid or mixed-lineage leukemia 5. (1859 aa) |
| | IL25 | Interleukin-25 isoform 2. (169 aa) |
| | ATP5IF1 | ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...] (108 aa) |
| | THPO | Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. (477 aa) |
| | SLC25A38 | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (304 aa) |
| | WASF2 | Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa) |
| | GATA1 | Erythroid transcription factor. (412 aa) |
| | ZFP36 | Uncharacterized protein. (372 aa) |
| | GLO1 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa) |
| | FASN | Uncharacterized protein. (1430 aa) |
| | OCSTAMP | Osteoclast stimulatory transmembrane protein. (503 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa) |
| | BATF3 | Basic leucine zipper transcriptional factor ATF-like 3. (122 aa) |
| | CD4 | CD4 molecule. (494 aa) |
| | NF1 | Neurofibromin 1. (2847 aa) |
| | HOXB7 | Homeobox protein Hox-B7. (217 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa) |
| | CCR7 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | IL31RA | Interleukin-31 receptor subunit alpha isoform 2. (717 aa) |
| | SNX10 | Sorting nexin-10 isoform 1. (200 aa) |
| | SP3 | Sp3 transcription factor. (789 aa) |
| | FLVCR1 | Feline leukemia virus subgroup C receptor-related protein 1. (559 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | MEF2C | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa) |
| | F2RL1 | Proteinase-activated receptor 2 preproprotein. (397 aa) |
| | DNASE2 | Deoxyribonuclease-2-alpha; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (By similarity); Belongs to the DNase II family. (363 aa) |
| | KLF1 | Kruppel-like factor 1. (367 aa) |
| | PRTN3 | Proteinase 3; Belongs to the peptidase S1 family. (268 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa) |
| | GAB3 | GRB2-associated-binding protein 3 isoform 2. (576 aa) |
| | ALAS2 | 5-aminolevulinate synthase. (587 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa) |
