STRINGSTRING
L3MBTL3 L3MBTL3 SRF SRF ADGRF5 ADGRF5 RCOR1 RCOR1 ETV2 ETV2 CITED2 CITED2 EPB42 EPB42 BMP4 BMP4 ARID4A ARID4A LYN LYN EPO EPO EPAS1 EPAS1 LYAR LYAR RB1 RB1 DMTN DMTN SH2B3 SH2B3 ABCB10 ABCB10 BCL6 BCL6 ALAS2 ALAS2 KLF1 KLF1 DNASE2 DNASE2 FLVCR1 FLVCR1 SP3 SP3 STAT5B STAT5B MED1 MED1 GATA1 GATA1 SLC25A38 SLC25A38 ATP5IF1 ATP5IF1 KMT2E KMT2E C15orf41 C15orf41 UFL1 UFL1 JAK2 JAK2 SLC4A1 SLC4A1 JAK3 JAK3 SMAD5 SMAD5 BAP1 BAP1 ADD1 ADD1 MPIG6B MPIG6B MFHAS1 MFHAS1 ERCC2 ERCC2 TRIM10 TRIM10 IKZF1 IKZF1 TAL1 TAL1 A0A286ZXY0_PIG A0A286ZXY0_PIG ZBTB7A ZBTB7A GATA3 GATA3 HSPA9 HSPA9 CEBPG CEBPG AHSP AHSP TSPO2 TSPO2 A0A287ATT1_PIG A0A287ATT1_PIG PKNOX1 PKNOX1 PLA2G10 PLA2G10 KCNQ1 KCNQ1 CASP3 CASP3 ZFPM1 ZFPM1 KLF2 KLF2 MAEA MAEA DYRK3 DYRK3 PTPN2 PTPN2 G6PD G6PD JMJD6 JMJD6 NCAPG2 NCAPG2 UBA5 UBA5 ADAR ADAR NCKAP1L NCKAP1L LOC100517166 LOC100517166 KIT KIT TMOD3 TMOD3 HCLS1 HCLS1 A0A5G2R3N8_PIG A0A5G2R3N8_PIG CDK5RAP3 CDK5RAP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
L3MBTL3Lethal(3)malignant brain tumor-like protein 3 isoform X2. (780 aa)
SRFSerum response factor. (512 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1340 aa)
RCOR1REST corepressor 1. (487 aa)
ETV2ETS variant 2. (242 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
EPB42Erythrocyte membrane protein band 4.2. (688 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ARID4AAT-rich interaction domain 4A. (1279 aa)
LYNTyrosine-protein kinase. (512 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa)
EPAS1Uncharacterized protein. (870 aa)
LYARLy1 antibody reactive. (386 aa)
RB1RB transcriptional corepressor 1. (938 aa)
DMTNDematin actin binding protein. (405 aa)
SH2B3SH2B adaptor protein 3. (600 aa)
ABCB10ATP binding cassette subfamily B member 10. (725 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (706 aa)
ALAS25-aminolevulinate synthase. (587 aa)
KLF1Kruppel-like factor 1. (367 aa)
DNASE2Deoxyribonuclease-2-alpha; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (By similarity); Belongs to the DNase II family. (363 aa)
FLVCR1Feline leukemia virus subgroup C receptor-related protein 1. (559 aa)
SP3Sp3 transcription factor. (789 aa)
STAT5BSignal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
GATA1Erythroid transcription factor. (412 aa)
SLC25A38Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (304 aa)
ATP5IF1ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...] (108 aa)
KMT2EMyeloid/lymphoid or mixed-lineage leukemia 5. (1859 aa)
C15orf41Chromosome 15 open reading frame 41. (287 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
SLC4A1Anion exchange protein. (924 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
BAP1BRCA1 associated protein 1. (759 aa)
ADD1Adducin 1. (786 aa)
MPIG6BIg-like domain-containing protein. (328 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1062 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
TRIM10Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis. (517 aa)
IKZF1IKAROS family zinc finger 1. (575 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
A0A286ZXY0_PIGUncharacterized protein. (139 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (596 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
CEBPGCCAAT enhancer binding protein gamma. (164 aa)
AHSPAlpha-hemoglobin-stabilizing protein. (92 aa)
TSPO2Translocator protein 2. (171 aa)
A0A287ATT1_PIGUncharacterized protein. (114 aa)
PKNOX1PBX/knotted 1 homeobox 1. (435 aa)
PLA2G10Phospholipase A(2). (188 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (771 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
ZFPM1Zinc finger protein, FOG family member 1. (965 aa)
KLF2Kruppel-like factor 2. (357 aa)
MAEAMacrophage erythroblast attacher. (591 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (545 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (447 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (649 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (413 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1164 aa)
UBA5Ubiquitin like modifier activating enzyme 5. (447 aa)
ADARAdenosine deaminase RNA specific. (1169 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
LOC100517166Uncharacterized protein. (152 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
TMOD3Uncharacterized protein. (386 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (525 aa)
A0A5G2R3N8_PIGUncharacterized protein. (135 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (513 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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