STRINGSTRING
ECM1 ECM1 BCOR BCOR EGR2 EGR2 KREMEN1 KREMEN1 P2RX7 P2RX7 PTK2B PTK2B KL KL SOX11 SOX11 PKDCC PKDCC SIX2 SIX2 OMD OMD BMP7 BMP7 BGLAP BGLAP DDR2 DDR2 OSR2 OSR2 BMP4 BMP4 SMAD6 SMAD6 SMAD7 SMAD7 TENT5A TENT5A DHRS3 DHRS3 ANO6 ANO6 WNT10B WNT10B MAPK1 MAPK1 ACTN3 ACTN3 BMPR2 BMPR2 RUNX2 RUNX2 ACVR2B ACVR2B CCN1 CCN1 FBN2 FBN2 MGP MGP PTPN11 PTPN11 CSF1 CSF1 SLC8A1 SLC8A1 CALCR CALCR MAPK3 MAPK3 LTBP3 LTBP3 INTU INTU BMP6 BMP6 TOB2 TOB2 TXLNG TXLNG NIPBL NIPBL AHSG AHSG TFAP2A TFAP2A HIF1A HIF1A NOTCH1 NOTCH1 ADRB2 ADRB2 FGF23 FGF23 CHSY1 CHSY1 KREMEN2 KREMEN2 SOST SOST RFLNB RFLNB NBR1 NBR1 LOC110257894 LOC110257894 LRP4 LRP4 ISG15 ISG15 PTN PTN BMPR1A BMPR1A I3L7W9_PIG I3L7W9_PIG MATN1 MATN1 SOX9 SOX9 ANKH ANKH SCUBE2 SCUBE2 MEF2C MEF2C COMP COMP PTH PTH GPR137 GPR137 ENPP1 ENPP1 ATP2B1 ATP2B1 RFLNA RFLNA ACVR2A ACVR2A GREM1 GREM1 WNT5A WNT5A BMP2 BMP2 LOC110257970 LOC110257970 OSR1 OSR1 TGFB2 TGFB2 NOTUM NOTUM S1PR1 S1PR1 ZBTB16 ZBTB16 TGFB3 TGFB3 ALOX5 ALOX5 TGFB1 TGFB1 SFRP1 SFRP1 BMP2K BMP2K LTF LTF FZD9 FZD9 ZMPSTE24 ZMPSTE24 PTGER4 PTGER4 SRGN SRGN BMPR1B BMPR1B CYP27B1 CYP27B1 ATRAID ATRAID GATA1 GATA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ECM1Extracellular matrix protein 1. (559 aa)
BCORANK_REP_REGION domain-containing protein. (693 aa)
EGR2E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (464 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
KLKlotho. (1011 aa)
SOX11Transcription factor SOX. (447 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
SIX2SIX homeobox 2. (296 aa)
OMDOsteomodulin. (422 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (866 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
TENT5ATerminal nucleotidyltransferase 5A. (434 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
ANO6Anoctamin. (924 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (931 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
CCN1Cellular communication network factor 1. (382 aa)
FBN2Fibrillin 2. (2910 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. (127 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CSF1Colony stimulating factor 1. (656 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. (490 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
INTUInturned planar cell polarity protein. (937 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
TOB2Protein Tob2 isoform X1. (353 aa)
TXLNGGamma-taxilin isoform 1. (512 aa)
NIPBLNipped-B protein. (2804 aa)
AHSGAlpha-2-HS-glycoprotein. (394 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa)
CHSY1Hexosyltransferase. (803 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
SOSTSclerostin. (212 aa)
RFLNBRefilin-B. (219 aa)
NBR1Next to BRCA1 gene 1 protein isoform X1. (960 aa)
LOC110257894Uncharacterized protein. (552 aa)
LRP4LDL receptor related protein 4. (1918 aa)
ISG15Ubiquitin-like modifier. (167 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
I3L7W9_PIGUncharacterized protein. (373 aa)
MATN1Matrilin 1. (496 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (494 aa)
SCUBE2CUB domain-containing protein. (539 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
GPR137G protein-coupled receptor 137. (423 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
ATP2B1Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa)
RFLNAUncharacterized protein. (266 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
LOC110257970ANK_REP_REGION domain-containing protein. (1679 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (570 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
ALOX5Arachidonate 5-lipoxygenase. (638 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
BMP2KBMP2 inducible kinase. (1129 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (704 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
SRGNSerglycin. (152 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
ATRAIDUncharacterized protein. (236 aa)
GATA1Erythroid transcription factor. (412 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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