STRINGSTRING
CEL CEL NPC1 NPC1 ARV1 ARV1 NPC2 NPC2 OSBPL2 OSBPL2 LDLR LDLR A0A5G2R7H0_PIG A0A5G2R7H0_PIG APOA2 APOA2 TPCN2 TPCN2 TSKU TSKU LDLRAP1 LDLRAP1 PPP1R1B PPP1R1B ABCG8 ABCG8 APOC3 APOC3 ABCA12 ABCA12 APOA4 APOA4 STARD3NL STARD3NL VPS4B VPS4B ABCG1 ABCG1 LSM1 LSM1 APOM APOM TSPO2 TSPO2 RELCH RELCH LIMA1 LIMA1 APOB APOB LRP6 LRP6 SOAT2 SOAT2 CES1 CES1 STARD3 STARD3 ABCA7 ABCA7 CFTR CFTR RAB11A RAB11A SERAC1 SERAC1 APOA1 APOA1 ABCG5 ABCG5 STARD4 STARD4 LIPG LIPG VPS4A VPS4A LCAT LCAT STX12 STX12 SPG11 SPG11 PODN PODN SOAT1 SOAT1 NPC1L1 NPC1L1 ABCG4 ABCG4 OSBP OSBP PIP4K2A PIP4K2A HNF1A HNF1A SCARB1 SCARB1 MSR1 MSR1 ABCA1 ABCA1 LIPC LIPC APOE APOE STARD5 STARD5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (585 aa)
NPC1NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular traf [...] (1276 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
NPC2NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmos [...] (154 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
A0A5G2R7H0_PIGVps4_C domain-containing protein. (184 aa)
APOA2Apolipoprotein A-II preproprotein. (100 aa)
TPCN2Uncharacterized protein. (765 aa)
TSKUTsukushi, small leucine rich proteoglycan. (357 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (336 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1. (200 aa)
ABCG8ATP binding cassette subfamily G member 8. (730 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
ABCA12ATP binding cassette subfamily A member 12. (2593 aa)
APOA4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. (392 aa)
STARD3NLSTARD3 N-terminal-like protein. (235 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
ABCG1ATP binding cassette subfamily G member 1. (679 aa)
LSM1Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (302 aa)
APOMApolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). (200 aa)
TSPO2Translocator protein 2. (171 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1222 aa)
LIMA1LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholest [...] (766 aa)
APOBApolipoprotein B-100. (4573 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
SOAT2O-acyltransferase. (566 aa)
CES1Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] (564 aa)
STARD3StAR related lipid transfer domain containing 3. (550 aa)
ABCA7ATP binding cassette subfamily A member 7. (2206 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa)
SERAC1Serine active site containing 1. (654 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
ABCG5ATP binding cassette subfamily G member 5. (657 aa)
STARD4StAR related lipid transfer domain containing 4. (213 aa)
LIPGLipase G, endothelial type. (501 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (518 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (471 aa)
STX12t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (369 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2467 aa)
PODNLRRNT domain-containing protein. (697 aa)
SOAT1O-acyltransferase. (549 aa)
NPC1L1NPC1-like intracellular cholesterol transporter 1 isoform 2. (1332 aa)
ABCG4ATP-binding cassette sub-family G member 4 isoform a. (646 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (809 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa)
HNF1AHepatocyte nuclear factor 1-alpha isoform 2. (631 aa)
SCARB1Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa)
MSR1Macrophage scavenger receptor 1. (446 aa)
ABCA1Uncharacterized protein. (2261 aa)
LIPCLipase C, hepatic type. (501 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
STARD5StAR related lipid transfer domain containing 5. (213 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.