STRINGSTRING
MITF MITF TOB2 TOB2 CALCR CALCR CSF1 CSF1 FARP2 FARP2 A0A5G2QBC0_PIG A0A5G2QBC0_PIG CSF1R CSF1R GPR183 GPR183 IREB2 IREB2 TYROBP TYROBP EPHA2 EPHA2 OSTM1 OSTM1 DCSTAMP DCSTAMP TNFSF11 TNFSF11 TCIRG1 TCIRG1 SNX10 SNX10 NF1 NF1 OCSTAMP OCSTAMP GLO1 GLO1 JUNB JUNB PIK3R1 PIK3R1 SBNO2 SBNO2 CD109 CD109 TNFRSF11A TNFRSF11A SFRP1 SFRP1 SRC SRC GPC3 GPC3 TGFB1 TGFB1 GPR68 GPR68 ANXA2 ANXA2 CTNNB1 CTNNB1 TRAF6 TRAF6 PAFAH1B1 PAFAH1B1 CREB1 CREB1 TREM2 TREM2 ATP6AP1 ATP6AP1 LRRK1 LRRK1 TCTA TCTA FOXP1 FOXP1 EFNA2 EFNA2 CCN4 CCN4 IL20 IL20 CD81 CD81 TF-2 TF-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
TOB2Protein Tob2 isoform X1. (353 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. (490 aa)
CSF1Colony stimulating factor 1. (656 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1163 aa)
A0A5G2QBC0_PIGGlyoxalase domain-containing protein. (113 aa)
CSF1RColony stimulating factor 1 receptor. (1053 aa)
GPR183G-protein coupled receptor 183 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
IREB2Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. (963 aa)
TYROBPTYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (109 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
OSTM1Osteoclastogenesis associated transmembrane protein 1. (335 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (487 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa)
SNX10Sorting nexin-10 isoform 1. (200 aa)
NF1Neurofibromin 1. (2847 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (503 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
SBNO2Strawberry notch homolog 2. (1314 aa)
CD109CD109 antigen isoform 1 preproprotein. (1449 aa)
TNFRSF11ATNF receptor superfamily member 11a. (629 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SRCTyrosine-protein kinase. (559 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa)
CTNNB1Catenin beta 1. (808 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
TREM2Ig-like domain-containing protein. (248 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (469 aa)
LRRK1Leucine rich repeat kinase 1. (2030 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
FOXP1Forkhead box P1. (692 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (216 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
IL20Interleukin 20. (175 aa)
CD81Tetraspanin. (258 aa)
TF-2Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (702 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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