STRINGSTRING
GDF5 GDF5 ACVRL1 ACVRL1 USP15 USP15 GDF3 GDF3 ETV2 ETV2 MEGF8 MEGF8 BMP8B BMP8B BMP8A BMP8A SMAD7 SMAD7 SMAD4 SMAD4 SMAD6 SMAD6 BMP4 BMP4 EXT1 EXT1 NOTCH2 NOTCH2 BMP7 BMP7 ZNF831 ZNF831 CCDC142 CCDC142 MSX1 MSX1 SFRP2 SFRP2 SMAD9 SMAD9 GDF2 GDF2 LOC100524517 LOC100524517 ZCCHC18 ZCCHC18 COMP COMP GDF1 GDF1 RGMB RGMB EGR1 EGR1 FST FST DLX3 DLX3 FAM83G FAM83G DSG4 DSG4 TMPRSS6 TMPRSS6 LEFTY2 LEFTY2 GDF7 GDF7 LOC102162178 LOC102162178 BMPR1B BMPR1B LOC100625207 LOC100625207 SFRP1 SFRP1 TGFB1 TGFB1 CHRDL1 CHRDL1 TGFB3 TGFB3 GDF15 GDF15 ZNF8 ZNF8 SMAD1 SMAD1 SMAD5 SMAD5 LEF1 LEF1 TGFB2 TGFB2 BMP2 BMP2 BMP5 BMP5 WNT5A WNT5A ACVR2A ACVR2A BMP10 BMP10 BMPR1A BMPR1A USP9X USP9X TGFBR3L TGFBR3L SLC39A5 SLC39A5 DLX5 DLX5 PDCD4 PDCD4 SOST SOST HES1 HES1 NODAL NODAL SMPD3 SMPD3 HJV HJV SCX SCX CHRD CHRD ATF2 ATF2 NOG NOG ABL1 ABL1 HES5 HES5 SMAD2 SMAD2 BMP6 BMP6 ACVR1 ACVR1 NANOG NANOG GDF6 GDF6 DDX5 DDX5 MAPK3 MAPK3 SPART SPART HFE HFE RGMA RGMA SLC33A1 SLC33A1 TMEM100 TMEM100 SOSTDC1 SOSTDC1 ACVR2B ACVR2B TWSG1 TWSG1 BMPER BMPER HIVEP1 HIVEP1 SMURF1 SMURF1 TGFBR3 TGFBR3 RUNX2 RUNX2 BMPR2 BMPR2 SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF5Growth differentiation factor 5. (499 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (924 aa)
GDF3Growth differentiation factor 3. (363 aa)
ETV2ETS variant 2. (242 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
BMP8BTGF_BETA_2 domain-containing protein. (401 aa)
BMP8ATGF_BETA_2 domain-containing protein. (360 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
ZNF831Zinc finger protein 831. (1649 aa)
CCDC142Coiled-coil domain containing 142. (768 aa)
MSX1Homeobox domain-containing protein. (303 aa)
SFRP2Uncharacterized protein. (294 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
GDF2Growth differentiation factor 2. (427 aa)
LOC100524517Left-right determination factor. (373 aa)
ZCCHC18Zinc finger CCHC-type containing 18. (378 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
GDF1Uncharacterized protein. (363 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (480 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
FSTFollistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (343 aa)
DLX3Distal-less homeobox 3. (287 aa)
FAM83GFamily with sequence similarity 83 member G. (812 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1042 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (812 aa)
LEFTY2Left-right determination factor. (366 aa)
GDF7Growth differentiation factor 7. (449 aa)
LOC102162178USP domain-containing protein; Belongs to the peptidase C19 family. (690 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC100625207USP domain-containing protein; Belongs to the peptidase C19 family. (2554 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CHRDL1Chordin like 1. (526 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
GDF15Growth differentiation factor 15. (308 aa)
ZNF8Zinc finger protein 8. (616 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
BMP10Bone morphogenetic protein 10 preproprotein. (423 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
USP9XPutative ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4; Belongs to the peptidase C19 family. (2554 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (285 aa)
SLC39A5Solute carrier family 39 member 5. (554 aa)
DLX5Homeobox protein DLX-5. (290 aa)
PDCD4Programmed cell death protein 4 isoform 1. (469 aa)
SOSTSclerostin. (212 aa)
HES1Uncharacterized protein. (280 aa)
NODALNodal growth differentiation factor. (316 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
HJVHemojuvelin BMP co-receptor. (432 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (310 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (1028 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
SMAD2Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] (472 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (729 aa)
NANOGHomeobox domain-containing protein. (304 aa)
GDF6Growth/differentiation factor 6 preproprotein. (459 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
SPARTSpartin. (666 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (395 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (456 aa)
SLC33A1Solute carrier family 33 member 1. (751 aa)
TMEM100Transmembrane protein 100 isoform X1. (134 aa)
SOSTDC1Sclerostin domain containing 1. (229 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
BMPERBMP binding endothelial regulator. (699 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2721 aa)
SMURF1E3 ubiquitin-protein ligase. (859 aa)
TGFBR3Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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