STRINGSTRING
ACVRL1 ACVRL1 SMAD4 SMAD4 BMP4 BMP4 CRB2 CRB2 SULF1 SULF1 NOTCH2 NOTCH2 MSX1 MSX1 GDF2 GDF2 KIAA1324L KIAA1324L KCP KCP TBX20 TBX20 PELO PELO ILK ILK GDF5 GDF5 KDR KDR GPC3 GPC3 ENG ENG NEO1 NEO1 SCUBE3 SCUBE3 CDH5 CDH5 HES1 HES1 ZNF423 ZNF423 NOTCH1 NOTCH1 FBXL15 FBXL15 UBE2O UBE2O HES5 HES5 NUMA1 NUMA1 RNF165 RNF165 CCN1 CCN1 TWSG1 TWSG1 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CRB2Crumbs cell polarity complex component 2. (1283 aa)
SULF1Sulfatase 1. (1108 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
MSX1Homeobox domain-containing protein. (303 aa)
GDF2Growth differentiation factor 2. (427 aa)
KIAA1324LKIAA1324 like. (1276 aa)
KCPKielin cysteine rich BMP regulator. (1783 aa)
TBX20T-box transcription factor TBX20 isoform 1. (449 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (384 aa)
ILKIntegrin linked kinase. (479 aa)
GDF5Growth differentiation factor 5. (499 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
NEO1Neogenin 1. (1465 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (1008 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa)
HES1Uncharacterized protein. (280 aa)
ZNF423Zinc finger protein 423 isoform X2. (1292 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
FBXL15F-box and leucine rich repeat protein 15. (371 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1296 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2134 aa)
RNF165Ring finger protein 165. (365 aa)
CCN1Cellular communication network factor 1. (382 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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