node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | CTNNB1 | ENSSSCP00000013166 | ENSSSCP00000031836 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Catenin beta 1. | 0.863 |
AR | KLHL10 | ENSSSCP00000013166 | ENSSSCP00000054606 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Kelch like family member 10. | 0.401 |
AR | SRD5A2 | ENSSSCP00000013166 | ENSSSCP00000009087 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). | 0.577 |
BMP6 | FGF10 | ENSSSCP00000055803 | ENSSSCP00000017886 | TGF_BETA_2 domain-containing protein. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.409 |
BMP6 | PDGFRA | ENSSSCP00000055803 | ENSSSCP00000048936 | TGF_BETA_2 domain-containing protein. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.630 |
CTNNB1 | AR | ENSSSCP00000031836 | ENSSSCP00000013166 | Catenin beta 1. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.863 |
CTNNB1 | FGF10 | ENSSSCP00000031836 | ENSSSCP00000017886 | Catenin beta 1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.527 |
CTNNB1 | FGF8 | ENSSSCP00000031836 | ENSSSCP00000066541 | Catenin beta 1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.514 |
CTNNB1 | LGR4 | ENSSSCP00000031836 | ENSSSCP00000014168 | Catenin beta 1. | Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. | 0.516 |
CTNNB1 | PDGFRA | ENSSSCP00000031836 | ENSSSCP00000048936 | Catenin beta 1. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.521 |
CTNNB1 | SHH | ENSSSCP00000031836 | ENSSSCP00000017394 | Catenin beta 1. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.621 |
CTNNB1 | WNT9B | ENSSSCP00000031836 | ENSSSCP00000056613 | Catenin beta 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.588 |
CTNNB1 | WT1 | ENSSSCP00000031836 | ENSSSCP00000019417 | Catenin beta 1. | Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] | 0.520 |
FGF10 | BMP6 | ENSSSCP00000017886 | ENSSSCP00000055803 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | TGF_BETA_2 domain-containing protein. | 0.409 |
FGF10 | CTNNB1 | ENSSSCP00000017886 | ENSSSCP00000031836 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Catenin beta 1. | 0.527 |
FGF10 | FGF8 | ENSSSCP00000017886 | ENSSSCP00000066541 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.601 |
FGF10 | PDGFRA | ENSSSCP00000017886 | ENSSSCP00000048936 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.851 |
FGF10 | SHH | ENSSSCP00000017886 | ENSSSCP00000017394 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.880 |
FGF8 | CTNNB1 | ENSSSCP00000066541 | ENSSSCP00000031836 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Catenin beta 1. | 0.514 |
FGF8 | FGF10 | ENSSSCP00000066541 | ENSSSCP00000017886 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.601 |