STRINGSTRING
WNT9B WNT9B BMP6 BMP6 KLHL10 KLHL10 PDGFRA PDGFRA CTNNB1 CTNNB1 HOXA13 HOXA13 GREB1 GREB1 WT1 WT1 FGF10 FGF10 SHH SHH HOXD13 HOXD13 LGR4 LGR4 AR AR HSD17B3 HSD17B3 TBX3 TBX3 SRD5A2 SRD5A2 SYCP2 SYCP2 GREB1L GREB1L ASB1 ASB1 FGF8 FGF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
KLHL10Kelch like family member 10. (608 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
CTNNB1Catenin beta 1. (808 aa)
HOXA13Homeobox A13. (388 aa)
GREB1Uncharacterized protein. (1970 aa)
WT1Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
HOXD13Homeobox protein Hox-D13. (341 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa)
HSD17B3Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). (346 aa)
SYCP2Synaptonemal complex protein 2. (1462 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1909 aa)
ASB1Ankyrin repeat and SOCS box containing 1. (463 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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