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CCL4 CCL4 ITGA1 ITGA1 TNFSF14 TNFSF14 CSF3R CSF3R KIT KIT NCKAP1L NCKAP1L GPR183 GPR183 LGALS3 LGALS3 FLT1 FLT1 CNR2 CNR2 SLC37A4 SLC37A4 CCL16 CCL16 CH25H CH25H CCL26 CCL26 CXCL16 CXCL16 CCL14 CCL14 PIKFYVE PIKFYVE PLEC PLEC TAFA4 TAFA4 JAML JAML GAS6 GAS6 TRPM4 TRPM4 LOC100514068 LOC100514068 SLC12A2 SLC12A2 PDGFB PDGFB PTN PTN SCG2 SCG2 CXCL13 CXCL13 EDN2 EDN2 CCL21 CCL21 LOC100516039 LOC100516039 HSD3B7 HSD3B7 CKLF CKLF TGFB2 TGFB2 CORO1A CORO1A PREX1 PREX1 S1PR1 S1PR1 CXADR CXADR VAV1 VAV1 LOC100515857 LOC100515857 SYK SYK FFAR2 FFAR2 CCL8 CCL8 CCL24 CCL24 CXCL10 CXCL10 PPIB PPIB MSMP MSMP LOC100737180 LOC100737180 ALOX5 ALOX5 S100A8 S100A8 SLAMF1 SLAMF1 CCL20 CCL20 ADAM8 ADAM8 S100A9 S100A9 CCL5 CCL5 C5AR1 C5AR1 ARHGEF5 ARHGEF5 GPRL15 GPRL15 TRPM2 TRPM2 PTPRO PTPRO CX3CR1 CX3CR1 I3L9Z6_PIG I3L9Z6_PIG CCL17 CCL17 DPEP1 DPEP1 LBP LBP CCL2 CCL2 CCL11 CCL11 CCL1 CCL1 CCR7 CCR7 NUP85 NUP85 PPIA PPIA F1SS05_PIG F1SS05_PIG CXCR5 CXCR5 IL17RC IL17RC CCL19 CCL19 EDNRB EDNRB TNFSF11 TNFSF11 AMCF-II AMCF-II CXCL8 CXCL8 SBDS SBDS SLAMF8 SLAMF8 XCL1 XCL1 ANXA1 ANXA1 LOC110260995 LOC110260995 CCL22 CCL22 SRP54 SRP54 IL16 IL16 ANO6 ANO6 PDE4B PDE4B CXCL11 CXCL11 CHGA CHGA TREM1 TREM1 PLA2G1B PLA2G1B PPBP PPBP CCL25 CCL25 VAV3 VAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa)
CSF3RGranulocyte colony-stimulating factor receptor. (848 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
GPR183G-protein coupled receptor 183 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
LGALS3Galectin. (271 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
CNR2Cannabinoid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
CCL16C-C motif chemokine. (120 aa)
CH25HCholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory eleme [...] (311 aa)
CCL26C-C motif chemokine. (94 aa)
CXCL16C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). (342 aa)
CCL14C-C motif chemokine. (99 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2055 aa)
PLECPlectin. (5422 aa)
TAFA4TAFA chemokine like family member 4. (140 aa)
JAMLJunction adhesion molecule like. (410 aa)
GAS6Uncharacterized protein. (682 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1213 aa)
LOC100514068Uncharacterized protein. (257 aa)
SLC12A2Solute carrier family 12 member 2. (1186 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
SCG2Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. (616 aa)
CXCL13C-X-C motif chemokine. (111 aa)
EDN2Endothelin 2. (180 aa)
CCL21Putative CCL21 chemokine. (134 aa)
LOC100516039C-C motif chemokine. (243 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7. (410 aa)
CKLFChemokine like factor. (113 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (492 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CXADRUncharacterized protein. (419 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
LOC100515857C-C motif chemokine. (132 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CCL8C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
CCL24SCY domain-containing protein. (183 aa)
CXCL10C-X-C motif chemokine. (104 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (202 aa)
MSMPBeta-microseminoprotein. (156 aa)
LOC100737180C-X-C motif chemokine 17. (119 aa)
ALOX5Arachidonate 5-lipoxygenase. (638 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
SLAMF1Ig-like domain-containing protein. (379 aa)
CCL20C-C motif chemokine. (153 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (835 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (222 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1574 aa)
GPRL15Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). (81 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1538 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1186 aa)
CX3CR1CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
I3L9Z6_PIGUncharacterized protein. (335 aa)
CCL17C-C motif chemokine. (102 aa)
DPEP1Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa)
LBPUncharacterized protein. (586 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
CCL11C-C motif chemokine. (97 aa)
CCL1C-C motif chemokine. (94 aa)
CCR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (684 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (160 aa)
F1SS05_PIGG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
CXCR5C-X-C chemokine receptor type 5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
IL17RCIL17_R_N domain-containing protein. (511 aa)
CCL19C-C motif chemokine. (100 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
AMCF-IIAlveolar macrophage chemotactic factor 2; Has chemotactic activity for porcine, and in a lesser extent, for human neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
SBDSRibosome maturation protein SBDS. (250 aa)
SLAMF8SLAM family member 8 isoform X1. (295 aa)
XCL1Lymphotactin isoform X1. (110 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
LOC110260995Uncharacterized protein. (123 aa)
CCL22C-C motif chemokine. (93 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1338 aa)
ANO6Anoctamin. (924 aa)
PDE4BPhosphodiesterase. (736 aa)
CXCL11C-X-C motif chemokine. (129 aa)
CHGAp-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. (596 aa)
TREM1Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). (252 aa)
PLA2G1BPhospholipase A2, major isoenzyme; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family. (146 aa)
PPBPPlatelet basic protein; Chemoattractant factor for neutrophils. (159 aa)
CCL25C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (220 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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