(82 nodes) Synaptic vesicle membrane network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	SYNDIG1	Synapse differentiation-inducing gene protein 1 isoform X2. (258 aa)
	SCAMP1	Secretory carrier-associated membrane protein 1; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. (326 aa)
	UNC13C	Unc-13 homolog C. (2214 aa)
	SLC9B2	Solute carrier family 9 member B2. (537 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa)
	SNAP47	Synaptosome associated protein 47. (449 aa)
	A0A287BA99_PIG	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family. (81 aa)
	A0A287B6X8_PIG	RING-type domain-containing protein. (509 aa)
	RAB26	RAB26, member RAS oncogene family. (249 aa)
	C16orf70	Chromosome 16 open reading frame 70. (450 aa)
	DOC2A	Double C2 domain alpha. (487 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (896 aa)
	SVOP	SV2 related protein. (551 aa)
	SEPTIN8	Septin 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (518 aa)
	SV2C	Synaptic vesicle glycoprotein 2C isoform X1. (724 aa)
	UNC13A	Uncharacterized protein. (1581 aa)
	SV2B	Synaptic vesicle glycoprotein 2B. (683 aa)
	MCTP2	Multiple C2 and transmembrane domain-containing protein 2 isoform X3. (912 aa)
	ATP6V1E1	ATPase H+ transporting V1 subunit E1. (224 aa)
	STX6	Syntaxin 6; Belongs to the syntaxin family. (306 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (242 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (469 aa)
	BORCS5	BLOC-1 related complex subunit 5. (194 aa)
	ATP2B1	Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
	DTNBP1	Uncharacterized protein. (373 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
	RAB5A	Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
	SYN3	Synapsin III. (580 aa)
	SYNPR	Synaptoporin. (288 aa)
	BCL2L1	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
	SLC17A8	Solute carrier family 17 member 8. (544 aa)
	ATP6V1G2	V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	SYN1	Synapsin-1 isoform Ia. (712 aa)
	PRRT1	Uncharacterized protein. (305 aa)
	SLC30A3	Uncharacterized protein. (464 aa)
	SYT5	Synaptotagmin 5. (385 aa)
	STX12	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (369 aa)
	SYT8	Synaptotagmin 8. (381 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (508 aa)
	SLC18A2	MFS domain-containing protein. (517 aa)
	TMEM163	Transmembrane protein 163. (287 aa)
	SYPL1	Synaptophysin like 1. (259 aa)
	SYT9	Synaptotagmin-9. (491 aa)
	RAB3A	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
	STX10	Syntaxin 10; Belongs to the syntaxin family. (353 aa)
	RAB11B	Uncharacterized protein. (205 aa)
	SLC17A6	Solute carrier family 17 member 6. (582 aa)
	SYP	Synaptophysin. (319 aa)
	SYT2	Synaptotagmin 2. (417 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (295 aa)
	SLC32A1	Vesicular inhibitory amino acid transporter. (526 aa)
	LAMP5	Lysosomal associated membrane protein family member 5. (280 aa)
	SYPL2	Synaptophysin like 2. (278 aa)
	SLC6A17	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (727 aa)
	SV2A	Synaptic vesicle glycoprotein 2A isoform 1. (742 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (397 aa)
	SYNGR4	Synaptogyrin. (234 aa)
	CPLX3	Complexin 3. (158 aa)
	SYT1	Synaptotagmin 1. (379 aa)
	LRRK2	Uncharacterized protein. (2501 aa)
	VAMP1	V-SNARE coiled-coil homology domain-containing protein. (221 aa)
	GABRA2	Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (511 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (189 aa)
	MCTP1	Multiple C2 and transmembrane domain containing 1. (995 aa)
	SLC18A1	Solute carrier family 18 member A1. (524 aa)
	RAB3B	RAB3B, member RAS oncogene family. (249 aa)
	SCAMP5	Secretory carrier-associated membrane protein. (252 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	UNC13B	Uncharacterized protein. (4266 aa)
	TPRG1L	HSac2 domain-containing protein. (277 aa)
	SYNGR3	Synaptogyrin. (253 aa)
	SLC17A7	Solute carrier family 17 member 7. (567 aa)
	A0A5G2QGM6_PIG	Uncharacterized protein. (194 aa)
	ICA1	Islet cell autoantigen 1. (572 aa)
	SYNGR2	Synaptogyrin. (226 aa)
	RPH3A	Rabphilin-3A isoform 1. (701 aa)
	SYNGR1	Synaptogyrin. (234 aa)
	SYN2	Synapsin II. (581 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (353 aa)
	OTOF	Otoferlin. (1997 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287BA99_PIG	A0A5G2QGM6_PIG	ENSSSCP00000053469	ENSSSCP00000063922	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	Uncharacterized protein.	0.924
A0A287BA99_PIG	ATP6AP1	ENSSSCP00000053469	ENSSSCP00000038892	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	ATPase H+ transporting accessory protein 1.	0.897
A0A287BA99_PIG	ATP6AP2	ENSSSCP00000053469	ENSSSCP00000061026	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	ATPase H+ transporting accessory protein 2.	0.922
A0A287BA99_PIG	ATP6V0A1	ENSSSCP00000053469	ENSSSCP00000041220	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.973
A0A287BA99_PIG	ATP6V1B2	ENSSSCP00000053469	ENSSSCP00000020994	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.945
A0A287BA99_PIG	ATP6V1C1	ENSSSCP00000053469	ENSSSCP00000006464	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.950
A0A287BA99_PIG	ATP6V1E1	ENSSSCP00000053469	ENSSSCP00000043781	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	ATPase H+ transporting V1 subunit E1.	0.924
A0A287BA99_PIG	ATP6V1G2	ENSSSCP00000053469	ENSSSCP00000031116	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.842
A0A5G2QGM6_PIG	A0A287BA99_PIG	ENSSSCP00000063922	ENSSSCP00000053469	Uncharacterized protein.	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	0.924
A0A5G2QGM6_PIG	ATP6AP1	ENSSSCP00000063922	ENSSSCP00000038892	Uncharacterized protein.	ATPase H+ transporting accessory protein 1.	0.987
A0A5G2QGM6_PIG	ATP6AP2	ENSSSCP00000063922	ENSSSCP00000061026	Uncharacterized protein.	ATPase H+ transporting accessory protein 2.	0.980
A0A5G2QGM6_PIG	ATP6V0A1	ENSSSCP00000063922	ENSSSCP00000041220	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.995
A0A5G2QGM6_PIG	ATP6V0C	ENSSSCP00000063922	ENSSSCP00000068480	Uncharacterized protein.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.924
A0A5G2QGM6_PIG	ATP6V1B2	ENSSSCP00000063922	ENSSSCP00000020994	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.996
A0A5G2QGM6_PIG	ATP6V1C1	ENSSSCP00000063922	ENSSSCP00000006464	Uncharacterized protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.990
A0A5G2QGM6_PIG	ATP6V1G2	ENSSSCP00000063922	ENSSSCP00000031116	Uncharacterized protein.	V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.986
ATP2B1	ATP6V0A1	ENSSSCP00000038808	ENSSSCP00000041220	Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...]	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.485
ATP2B1	ATP6V1E1	ENSSSCP00000038808	ENSSSCP00000043781	Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...]	ATPase H+ transporting V1 subunit E1.	0.429
ATP6AP1	A0A287BA99_PIG	ENSSSCP00000038892	ENSSSCP00000053469	ATPase H+ transporting accessory protein 1.	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	0.897
ATP6AP1	A0A5G2QGM6_PIG	ENSSSCP00000038892	ENSSSCP00000063922	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.987