STRINGSTRING
WNT10B WNT10B ACVRL1 ACVRL1 MESP1 MESP1 ETV2 ETV2 KDF1 KDF1 BMP4 BMP4 PRKCH PRKCH NCOA3 NCOA3 BMP7 BMP7 ATOH8 ATOH8 ATOH1 ATOH1 GDF2 GDF2 PAX4 PAX4 MACROH2A1 MACROH2A1 TMEM100 TMEM100 TRIM16 TRIM16 AHI1 AHI1 NUMA1 NUMA1 BMP6 BMP6 VDR VDR FGF2 FGF2 NKX2-2 NKX2-2 PROM1 PROM1 NOTCH1 NOTCH1 MACROH2A2 MACROH2A2 PTCH2 PTCH2 GDNF GDNF BAD BAD COMMD5 COMMD5 BTG1 BTG1 SFRP4 SFRP4 BMP2 BMP2 LIF LIF PAX6 PAX6 CTNNB1 CTNNB1 LHX1 LHX1 PTCH1 PTCH1 SERPINE1 SERPINE1 TP73 TP73 CYP27B1 CYP27B1 VEZF1 VEZF1 ALOX15B ALOX15B FOXN1 FOXN1 MED1 MED1 ETV4 ETV4 SOX9 SOX9 FOXJ1 FOXJ1 ZBED2 ZBED2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
ETV2ETS variant 2. (242 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PRKCHProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
NCOA3Uncharacterized protein. (1296 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
ATOH8Atonal bHLH transcription factor 8. (315 aa)
ATOH1Atonal bHLH transcription factor 1. (353 aa)
GDF2Growth differentiation factor 2. (427 aa)
PAX4Paired box 4. (345 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
TMEM100Transmembrane protein 100 isoform X1. (134 aa)
TRIM16Uncharacterized protein. (582 aa)
AHI1Abelson helper integration site 1. (1114 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2134 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
VDRVitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
PROM1Prominin 1. (838 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
PTCH2Patched 2. (1207 aa)
GDNFGlial cell line-derived neurotrophic factor isoform 1. (211 aa)
BADBCL2 associated agonist of cell death. (209 aa)
COMMD5COMM domain containing 5. (260 aa)
BTG1B-cell translocation protein 1. (171 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
LIFLeukemia inhibitory factor isoform X1. (202 aa)
PAX6Paired box 6. (498 aa)
CTNNB1Catenin beta 1. (808 aa)
LHX1LIM homeobox 1. (436 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
SERPINE1Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
VEZF1Vascular endothelial zinc finger 1. (526 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (718 aa)
FOXN1Forkhead box N1. (671 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
ETV4ETS variant 4. (485 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
FOXJ1Forkhead box J1. (421 aa)
ZBED2Zinc finger BED domain-containing protein 2. (217 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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