(55 nodes) Cortical cytoskeleton organization network (Sus scrofa)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	RAC3	Rac family small GTPase 3. (192 aa)
	RACGAP1	Rac GTPase activating protein 1. (634 aa)
	EZR	Ezrin. (562 aa)
	RAB13	Uncharacterized protein. (203 aa)
	RHOC	Ras homolog family member C. (202 aa)
	STRIP1	Striatin-interacting protein 1 isoform 1. (837 aa)
	IKBKB	Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
	AKAP11	A-kinase anchoring protein 11. (1902 aa)
	RHOF	Ras homolog family member F, filopodia associated. (249 aa)
	NLGN1	Neuroligin 1. (823 aa)
	CALR	Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa)
	VIL1	Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa)
	ANLN	Anillin actin binding protein. (1144 aa)
	RHOBTB3	Rho related BTB domain containing 3. (609 aa)
	FHOD3	Formin homology 2 domain containing 3. (1614 aa)
	EHD2	EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
	RHOD	Ras homolog family member D. (203 aa)
	F1RSX1_PIG	Uncharacterized protein. (200 aa)
	RND2	Rho family GTPase 2. (231 aa)
	FMNL3	Formin-like protein 3 isoform X4. (1027 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	WDR1	WD repeat-containing protein 1 isoform 1. (606 aa)
	PPP2R3C	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	RHOQ	Rho-related GTP-binding protein RhoQ. (205 aa)
	TLN1	Talin 1. (2558 aa)
	FHOD1	Formin homology 2 domain containing 1. (1069 aa)
	NCKAP1	NCK associated protein 1. (1134 aa)
	RHOBTB1	Rho-related BTB domain-containing protein 1 isoform 1. (698 aa)
	EPB41L3	Erythrocyte membrane protein band 4.1 like 3. (1213 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	EPB41L1	FERM domain-containing protein. (1750 aa)
	FMNL1	Formin like 1. (1175 aa)
	LLGL2	LLGL scribble cell polarity complex component 2. (1048 aa)
	RND3	Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. (244 aa)
	RHOG	Uncharacterized protein. (394 aa)
	PLEC	Plectin. (5422 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (1028 aa)
	EPB41L2	Erythrocyte membrane protein band 4.1 like 2. (1047 aa)
	PLS1	Plastin 1. (637 aa)
	ARF6	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...] (175 aa)
	RND1	Rho family GTPase 1. (244 aa)
	ROCK2	Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
	RAC1	Rac family small GTPase 1. (186 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (1012 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	A0A5G2QL47_PIG	Uncharacterized protein. (116 aa)
	NCKAP1L	NCK associated protein 1 like. (1128 aa)
	PLEK	Pleckstrin. (408 aa)
	CAVIN3	Caveolae associated protein 3. (290 aa)
	RHOB	Rho-related GTP-binding protein RhoB. (196 aa)
	LLGL1	LLGL scribble cell polarity complex component 1. (1095 aa)
	RAC2	Rac family small GTPase 2. (217 aa)
	FMNL2	Formin like 2. (1092 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5G2QL47_PIG	ARF6	ENSSSCP00000065281	ENSSSCP00000058854	Uncharacterized protein.	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...]	0.400
A0A5G2QL47_PIG	RHOF	ENSSSCP00000065281	ENSSSCP00000010470	Uncharacterized protein.	Ras homolog family member F, filopodia associated.	0.632
A0A5G2QL47_PIG	RND1	ENSSSCP00000065281	ENSSSCP00000059270	Uncharacterized protein.	Rho family GTPase 1.	0.429
ANLN	FMNL2	ENSSSCP00000017646	ENSSSCP00000073266	Anillin actin binding protein.	Formin like 2.	0.419
ANLN	FMNL3	ENSSSCP00000017646	ENSSSCP00000026968	Anillin actin binding protein.	Formin-like protein 3 isoform X4.	0.400
ANLN	RACGAP1	ENSSSCP00000017646	ENSSSCP00000000230	Anillin actin binding protein.	Rac GTPase activating protein 1.	0.908
ANLN	RHOA	ENSSSCP00000017646	ENSSSCP00000045785	Anillin actin binding protein.	Transforming protein RhoA isoform 1.	0.744
ANLN	RHOB	ENSSSCP00000017646	ENSSSCP00000069510	Anillin actin binding protein.	Rho-related GTP-binding protein RhoB.	0.786
ANLN	RHOBTB1	ENSSSCP00000017646	ENSSSCP00000044587	Anillin actin binding protein.	Rho-related BTB domain-containing protein 1 isoform 1.	0.427
ANLN	RHOC	ENSSSCP00000017646	ENSSSCP00000007228	Anillin actin binding protein.	Ras homolog family member C.	0.786
ANLN	RHOF	ENSSSCP00000017646	ENSSSCP00000010470	Anillin actin binding protein.	Ras homolog family member F, filopodia associated.	0.499
ANLN	RND1	ENSSSCP00000017646	ENSSSCP00000059270	Anillin actin binding protein.	Rho family GTPase 1.	0.547
ANLN	RND3	ENSSSCP00000017646	ENSSSCP00000051155	Anillin actin binding protein.	Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.	0.547
ANLN	ROCK1	ENSSSCP00000017646	ENSSSCP00000063816	Anillin actin binding protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.516
ANLN	ROCK2	ENSSSCP00000017646	ENSSSCP00000060082	Anillin actin binding protein.	Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...]	0.516
ARF6	A0A5G2QL47_PIG	ENSSSCP00000058854	ENSSSCP00000065281	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...]	Uncharacterized protein.	0.400
ARF6	F1RSX1_PIG	ENSSSCP00000058854	ENSSSCP00000026359	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...]	Uncharacterized protein.	0.400
ARF6	PLEK	ENSSSCP00000058854	ENSSSCP00000067331	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...]	Pleckstrin.	0.504
ARF6	RHOA	ENSSSCP00000058854	ENSSSCP00000045785	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...]	Transforming protein RhoA isoform 1.	0.614
ARF6	RHOG	ENSSSCP00000058854	ENSSSCP00000051183	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...]	Uncharacterized protein.	0.414