17 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPHA2	Ephrin type-A receptor 2 isoform 1. (975 aa)
	CRB2	Crumbs cell polarity complex component 2. (1283 aa)
	EFNA1	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] (205 aa)
	PPP1R35	Protein phosphatase 1 regulatory subunit 35. (268 aa)
	F1SF13_PIG	Cobl domain-containing protein. (406 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
	KDM6A	Lysine demethylase 6A. (1400 aa)
	YAP1	Yes associated protein 1. (432 aa)
	TEAD2	TEA domain transcription factor 2. (457 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	TBXT	T-box transcription factor T. (435 aa)
	ID3	BHLH domain-containing protein. (118 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	GLI1	Zinc finger protein GLI1 isoform X1. (1106 aa)
	COL13A1	Collagen type XIII alpha 1 chain. (726 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL13A1	COL2A1	ENSSSCP00000074365	ENSSSCP00000036099	Collagen type XIII alpha 1 chain.	Collagen type II alpha 1 chain.	0.516
COL2A1	COL13A1	ENSSSCP00000036099	ENSSSCP00000074365	Collagen type II alpha 1 chain.	Collagen type XIII alpha 1 chain.	0.516
COL2A1	SOX9	ENSSSCP00000036099	ENSSSCP00000018278	Collagen type II alpha 1 chain.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.906
EFNA1	EPHA2	ENSSSCP00000006959	ENSSSCP00000003769	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	Ephrin type-A receptor 2 isoform 1.	0.998
EPHA2	EFNA1	ENSSSCP00000003769	ENSSSCP00000006959	Ephrin type-A receptor 2 isoform 1.	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	0.998
GLI1	SOX9	ENSSSCP00000057276	ENSSSCP00000018278	Zinc finger protein GLI1 isoform X1.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.545
NOG	SOX9	ENSSSCP00000053671	ENSSSCP00000018278	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.700
SOX9	COL2A1	ENSSSCP00000018278	ENSSSCP00000036099	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Collagen type II alpha 1 chain.	0.906
SOX9	GLI1	ENSSSCP00000018278	ENSSSCP00000057276	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Zinc finger protein GLI1 isoform X1.	0.545
SOX9	NOG	ENSSSCP00000018278	ENSSSCP00000053671	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.700
SOX9	WNT5A	ENSSSCP00000018278	ENSSSCP00000037791	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.519
TEAD2	YAP1	ENSSSCP00000034524	ENSSSCP00000033204	TEA domain transcription factor 2.	Yes associated protein 1.	0.983
WNT11	WNT5A	ENSSSCP00000019221	ENSSSCP00000037791	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.570
WNT5A	SOX9	ENSSSCP00000037791	ENSSSCP00000018278	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.519
WNT5A	WNT11	ENSSSCP00000037791	ENSSSCP00000019221	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.570
YAP1	TEAD2	ENSSSCP00000033204	ENSSSCP00000034524	Yes associated protein 1.	TEA domain transcription factor 2.	0.983