(59 nodes) Receptor tyrosine kinase binding network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SH2B2	SH2B adaptor protein 2. (695 aa)
	CBL	Cbl proto-oncogene. (914 aa)
	CRK	CRK proto-oncogene, adaptor protein. (385 aa)
	MST1	Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	ALKAL2	ALK and LTK ligand 2. (152 aa)
	GFRAL	GDNF family receptor alpha like. (457 aa)
	PITPNM1	Phosphatidylinositol transfer protein membrane associated 1. (1243 aa)
	RNF41	E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	PITPNM2	Phosphatidylinositol transfer protein membrane associated 2. (1326 aa)
	CBLC	Cbl proto-oncogene C. (561 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	MYOC	Myocilin. (489 aa)
	ELMO2	Engulfment and cell motility 2. (732 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	TRAT1	T cell receptor associated transmembrane adaptor 1. (181 aa)
	RACK1	Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (By similarity). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to [...] (317 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	PTPN14	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1186 aa)
	ZPR1	ZPR1 zinc finger. (455 aa)
	PSPN	Persephin. (153 aa)
	HYAL2	Hyaluronidase. (476 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	PITPNM3	PITPNM family member 3. (1730 aa)
	ANGPT2	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). (495 aa)
	ANGPT1	Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). (510 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	FIZ1	FLT3 interacting zinc finger 1. (500 aa)
	PIK3R2	Uncharacterized protein. (772 aa)
	SHC2	Uncharacterized protein. (623 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (447 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (304 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1977 aa)
	SHC3	SHC adaptor protein 3. (656 aa)
	NRTN	Neurturin. (197 aa)
	GRB14	Growth factor receptor-bound protein 14 isoform 1. (540 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (550 aa)
	GAB2	GRB2 associated binding protein 2. (740 aa)
	CPNE3	Copine 3. (571 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
	ALKAL1	ALK and LTK ligand 1. (121 aa)
	GAS6	Uncharacterized protein. (682 aa)
	CBLB	E3 ubiquitin-protein ligase CBL-B isoform X1. (1047 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (766 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (368 aa)
	GDNF	Glial cell line-derived neurotrophic factor isoform 1. (211 aa)
	LRP4	LDL receptor related protein 4. (1918 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	SH2B3	SH2B adaptor protein 3. (600 aa)
	DOK2	Uncharacterized protein. (410 aa)
	STAP1	Signal transducing adaptor family member 1. (295 aa)
	SH2B1	SH2B adaptor protein 1. (757 aa)
	PLCG1	Phosphoinositide phospholipase C. (1379 aa)
	ANGPT4	Angiopoietin 4. (503 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (495 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	ANGPT2	ENSSSCP00000065500	ENSSSCP00000067734	Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	0.931
ANGPT1	ANGPT4	ENSSSCP00000065500	ENSSSCP00000007666	Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).	Angiopoietin 4.	0.903
ANGPT2	ANGPT1	ENSSSCP00000067734	ENSSSCP00000065500	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).	0.931
ANGPT2	ANGPT4	ENSSSCP00000067734	ENSSSCP00000007666	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Angiopoietin 4.	0.920
ANGPT4	ANGPT1	ENSSSCP00000007666	ENSSSCP00000065500	Angiopoietin 4.	Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).	0.903
ANGPT4	ANGPT2	ENSSSCP00000007666	ENSSSCP00000067734	Angiopoietin 4.	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	0.920
ARHGEF16	DOCK4	ENSSSCP00000045630	ENSSSCP00000056810	Rho guanine nucleotide exchange factor 16.	Dedicator of cytokinesis 4; Belongs to the DOCK family.	0.573
CBL	CBLB	ENSSSCP00000033673	ENSSSCP00000048070	Cbl proto-oncogene.	E3 ubiquitin-protein ligase CBL-B isoform X1.	0.920
CBL	CBLC	ENSSSCP00000033673	ENSSSCP00000040134	Cbl proto-oncogene.	Cbl proto-oncogene C.	0.908
CBL	CRK	ENSSSCP00000033673	ENSSSCP00000034913	Cbl proto-oncogene.	CRK proto-oncogene, adaptor protein.	0.977
CBL	CRKL	ENSSSCP00000033673	ENSSSCP00000010768	Cbl proto-oncogene.	CRK like proto-oncogene, adaptor protein.	0.995
CBL	FRS2	ENSSSCP00000033673	ENSSSCP00000053238	Cbl proto-oncogene.	Fibroblast growth factor receptor substrate 2.	0.811
CBL	GRB2	ENSSSCP00000033673	ENSSSCP00000018229	Cbl proto-oncogene.	Growth factor receptor-bound protein 2 isoform 1.	0.998
CBL	NCK1	ENSSSCP00000033673	ENSSSCP00000025894	Cbl proto-oncogene.	Cytoplasmic protein.	0.759
CBL	NCK2	ENSSSCP00000033673	ENSSSCP00000042553	Cbl proto-oncogene.	Cytoplasmic protein.	0.446
CBL	PIK3R1	ENSSSCP00000033673	ENSSSCP00000024885	Cbl proto-oncogene.	Phosphoinositide-3-kinase regulatory subunit 1.	0.978
CBL	PIK3R2	ENSSSCP00000033673	ENSSSCP00000060475	Cbl proto-oncogene.	Uncharacterized protein.	0.794
CBL	PLCG1	ENSSSCP00000033673	ENSSSCP00000007834	Cbl proto-oncogene.	Phosphoinositide phospholipase C.	0.849
CBL	PTPN11	ENSSSCP00000033673	ENSSSCP00000064345	Cbl proto-oncogene.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.709
CBL	SH2B1	ENSSSCP00000033673	ENSSSCP00000008333	Cbl proto-oncogene.	SH2B adaptor protein 1.	0.500